β-carboline alkaloids from Trigonostemon filipes and Trigonostemon lii

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• 作者：Shi-Fei Li (1) (2)
  Yuan-Yuan Cheng (1) (2)
  Yu Zhang (1)
  Shun-Lin Li (1)
  Hong-Ping He (1)
  Xiao-Jiang Hao (1)
  
• 关键词：Trigonostemon filipes ; Trigonostemon lii ; β ; carboline alkaloids ; trifilines A ; C ; trigonoine C
• 刊名：Natural Products and Bioprospecting
• 出版年：2012
• 出版时间：June 2012
• 年：2012
• 卷：2
• 期：3
• 页码：126-129
• 全文大小：603KB
• 参考文献：1. Kiu, H. S.; Huang, S. M.; Chang, Y. T. / In Flora Reipublicae Popularis Sinicae; Wu, Z. Y., Ed.; Science Press: Beijing, 1996; Vol. 44, pp 162-69.
  2. Li, S. F.; Di, Y. T.; Li, S. L.; Zhang, Y.; Yang, F. M.; Sun, Q. Y.; Simo, J. M.; He, H. P.; Hao, X. J. / J. Nat. Prod. 2011, / 74, 464-69 CrossRef
  3. Hu, X. J.; Wang, Y. H.; Kong, N. Y.; He, H. P.; Gao, S.; Liu, H. Y.; Ding, J.; Xie, H.; Di, Y. T.; Hao, X. J. / Tetrahedron Lett. 2009, / 50, 2917-919 CrossRef
  4. Tan, C. J.; Di, Y. T.; Wang, Y. H.; Zhang, Y.; Si, Y. K.; Zhang, Q.; Gao, S.; Hu, X. J.; Fan, X.; Li, S. F.; Hao, X. J. / Org. Lett. 2010, / 12, 2370-373 CrossRef
  5. Li, S. F.; Di, Y. T.; He, H. P.; Zhang, Y.; Wang, Y. H.; Yin, J. L.; Tan, C. J.; Li, S. L.; Hao, X. J. / Tetrahedron Lett. 2011, / 52, 3186-188 CrossRef
  6. Li, S. F.; Zhang, Y.; Li, Y.; Li, X. R.; Kong, L. M.; Tan, C. J.; Li, S. L.; Di, Y. T.; He, H. P.; Hao, X. J. / Bioorg. Med. Chem. Lett. 2012, / 22, 2296-299. CrossRef
  7. Wu, F. E.; Koike, K.; Nikaido, T.; Sakamoto, T.; Ohmoto, T.; Ikeda, K. / Chem. Pharm. Bull. 1989, / 37, 1808-809 CrossRef
  8. Hu, X. J.; Di, Y. T.; Wang, Y. H.; Kong, N. Y.; Gao, S.; Li, C. S.; Liu, H. Y.; He, H. P.; Ding, J.; Xie, H.; Hao, X. J. / Planta Med. 2009, / 75, 1157-161. CrossRef
  9. Jain, M. P.; Koul, S. K.; Dhar, K. L.; Atal, C. K. / Phytochemistry 1980, / 19, 1880-882. CrossRef
  10. Tokuhiro, W.; Kazuhiko, H.; Jun, S; Michiyo, O.; Noriko, T.; Harumi, H.; Keiko, T.; Kayo, Y.; Akihiro, O. / Heterocycles 1989, / 29, 123-31. CrossRef
  11. Wang, J. H.; Tam, S. C.; Huang, H.; Ouyang, D. Y.; Wang, Y. Y.; Zheng, Y. T. / Biochem. Biophys. Res. Commun. 2004, / 317, 965-71. CrossRef
  
• 作者单位：Shi-Fei Li (1) (2)
  Yuan-Yuan Cheng (1) (2)
  Yu Zhang (1)
  Shun-Lin Li (1)
  Hong-Ping He (1)
  Xiao-Jiang Hao (1)
  
  1. State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, 650201, China
  2. Graduate University of Chinese Academy of Sciences, Beijing, 100049, China
  
• ISSN：2192-2209

文摘

Six β-carboline alkaloids including three new ones, trifilines A-C (1-strong class="a-plus-plus">3) were isolated from Trigonostemon filipes, along with a new β-carboline alkaloid, trigonoine C (7) isolated from Trigonostemon lii. Their structures were elucidated by extensive spectroscopic techniques. Trifilines A (1) and B (2) showed weak anti-HIV-1 activity with EC50 values of 54.61 μg/mL and 9.75 μg/mL, along with TI (Therapeutic index) values of 1.52 and 1.42, respectively. This is the first time to report the chemical constituents of Trigonostemon filipes.