In vitro evaluation of β-carboline alkaloids as potential anti-Toxoplasma agents
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- 作者：Maria L Alomar (11)
Federico AO Rasse-Suriani (12)
Agustina Ganuza (11)
Verónica M Cóceres (11)
Franco M Cabrerizo (12)
Sergio O Angel (11) - 关键词：Toxoplasma gondii ; β ; carbolines ; Drug ; Invasion ; Cell cycle
- 刊名：BMC Research Notes
- 出版年：2013
- 出版时间：December 2013
- 年：2013
- 卷：6
- 期：1
- 全文大小：247KB
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Federico AO Rasse-Suriani (12)
Agustina Ganuza (11)
Verónica M Cóceres (11)
Franco M Cabrerizo (12)
Sergio O Angel (11)
11. Laboratorio de Parasitología Molecular, IIB-INTECH, CONICET/UNSAM, Av. Intendente Marino Km. 8.2, C.C 164, (B7130IIWA) Chascomús, Prov. Buenos Aires, Argentina
12. Laboratorio de Fotoquímica y Fotobiología Molecular, IIB-INTECH, CONICET/UNSAM, Av. Intendente Marino Km. 8.2, C.C 164, (B7130IIWA) Chascomús, Prov. Buenos Aires, Argentina
文摘
Background Toxoplasmosis is a worldwide infection caused by the protozoan parasite Toxoplasma gondii, which causes chorioretinitis and neurological defects in congenitally infected newborns or immunodeficient patients. The efficacy of the current treatment is limited, primarily by serious host toxicity. In recent years, research has focused on the development of new drugs against T. gondii. β-Carbolines (βCs), such as harmane, norharmane and harmine, are a group of naturally occurring alkaloids that show microbicidal activity. In this work, harmane, norharmane and harmine were tested against T. gondii. Findings The treatment of extracellular tachyzoites with harmane, norharmane and harmine showed a 2.5 to 3.5-fold decrease in the invasion rates at doses of 40 μM (harmane and harmine) and 2.5 μM (norharmane) compared with the untreated parasites. Furthermore, an effect on the replication rate could also be observed with a decrease of 1 (harmane) and 2 (norharmane and harmine) division rounds at doses of 5 to 12.5 μM. In addition, the treated parasites presented either delayed or no monolayer lysis compared with the untreated parasites. Conclusions The three βC alkaloids studied (norharmane, harmane and harmine) exhibit anti-T. gondii effects as evidenced by the partial inhibition of parasite invasion and replication. A dose–response effect was observed at a relatively low drug concentration (< 40 μM), at which no cytotoxic effect was observed on the host cell line (Vero).