Dose-dependent induction of astrocyte activation and reactive astrogliosis in mouse brain following maternal exposure to carbon black nanoparticle
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- 作者：Atsuto Onoda ; Ken Takeda ; Masakazu Umezawa
- 关键词：Nanoparticle ; Carbon black ; Maternal exposure ; Brain ; Astrocyte ; Glial fibrillary acidic protein ; Aquaporin ; 4 ; Western blotting ; Immunohistochemistry ; Immunofluorescence ; Microarray
- 刊名：Particle and Fibre Toxicology
- 出版年：2017
- 出版时间：December 2017
- 年：2017
- 卷：14
- 期：1
- 全文大小：2349KB
- 刊物主题：Pharmacology/Toxicology; Pneumology/Respiratory System; Nanotechnology; Public Health; Environmental Health;
- 出版者：BioMed Central
- ISSN：1743-8977
- 卷排序：14
文摘
BackgroundRecent studies indicate that maternal exposure to ambient ultrafine particles and nanoparticles has adverse effects of on the central nervous system. Quantitative dose–response data is required to better understand the developmental neurotoxicity of nanoparticles. The present study investigated dose-dependent effects of maternal exposure to carbon black nanoparticle (CB-NP) on astrocyte in the brains of mouse offspring.