Invasive lobular carcinoma of the breast: morphology, biomarkers and ’omics
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- 作者：Amy E McCart Reed ; Jamie R Kutasovic ; Sunil R Lakhani…
- 刊名：Breast Cancer Research
- 出版年：2015
- 出版时间：December 2015
- 年：2015
- 卷：17
- 期：1
- 全文大小：2,549 KB
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Jamie R Kutasovic (1)
Sunil R Lakhani (1) (2) (3)
Peter T Simpson (1) (3)
1. The University of Queensland, UQ Centre for Clinical Research, Herston, QLD, 4029, Australia
2. Pathology Queensland, The Royal Brisbane & Women’s and Gold Coast Hospitals, Herston, QLD, 4029, Australia
3. School of Medicine, The University of Queensland, Herston, QLD, 4006, Australia- 刊物主题：Cancer Research; Oncology;
- 出版者：BioMed Central
- ISSN：1465-5411
- 作者单位：Amy E McCart Reed (1)
文摘
Invasive lobular carcinoma of the breast is the most common ‘special-morphological subtype of breast cancer, comprising up to 15% of all cases. Tumours are generally of a good prognostic phenotype, being low histological grade and low mitotic index, hormone receptor positive and HER2, p53 and basal marker negative, and with a generally good response to endocrine therapy. Despite this, clinicians face countless challenges in the diagnosis and long-term management of patients, as they encounter a tumour that can be difficult to detect through screening, elicits a very invasive nature, a propensity for widespread metastatic colonisation and, consequently, in some studies a worse long-term poor outcome compared with invasive carcinoma of no special type. Here we review the morphological and molecular features that underpin the disparate biological and clinical characteristics of this fascinating tumour type.