Immunohistochemical analyses of CD44 variant isoforms in invasive micropapillary carcinoma of the breast: comparison with a concurrent conventional invasive carcinoma of no special type component

详细信息    查看全文

• 作者：Tomoko Umeda ; Mitsuaki Ishida ; Satoshi Murata ; Tsuyoshi Mori ; Yuki Kawai…
• 关键词：Invasive micropapillary carcinoma ; CD44 ; CD44 variant isoforms ; Lymph node metastasis
• 刊名：Breast Cancer
• 出版年：2016
• 出版时间：November 2016
• 年：2016
• 卷：23
• 期：6
• 页码：869-875
• 全文大小：1,347 KB
• 刊物主题：Surgical Oncology; Oncology; Surgery; Cancer Research;
• 出版者：Springer Japan
• ISSN：1880-4233
• 卷排序：23

文摘

BackgroundInvasive micropapillary carcinoma (IMPC) is a distinct histopathological variant of breast carcinoma and frequently develops lymph node metastases. CD44 is a family of transmembrane glycoprotein receptors with multiple variant isoforms (CD44v), which have tissue-specific expression. Previous studies have demonstrated a loss or gain of CD44v and CD44 standard form (CD44s) expression in breast carcinomas. In this study, we analyzed the immunoprofiles of CD44s, CD44v6, and CD44v9 in IMPC and compared them with those in a concurrent invasive carcinoma of no special type (ICNST) component, thus clarifying the significance of CD44 expression in IMPC.