Fully-Coupled Electromechanical Simulations of the LV Dog Anatomy Using HPC: Model Testing and Verification
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- 作者：Jazmin Aguado-Sierra (19)
Alfonso Santiago (19)
Matias I. Rivero (19)
Mari帽a L贸pez-Yunta (19)
David Soto-Iglesias (20)
Lydia Dux-Santoy (20)
Oscar Camara (20)
Mariano Vazquez (19) - 关键词：High ; Performance Computing (HPC) ; Electromechanical simulations ; Canine model ; Ground ; truth data ; Verification
- 刊名：Lecture Notes in Computer Science
- 出版年：2015
- 出版时间：2015
- 年：2015
- 卷：8896
- 期：1
- 页码：114-122
- 全文大小：979 KB
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15. Flaim, S.N., Giles, W.R., McCulloch, A.: Contributions of sustained ina and ikv4.3 to transmural heterogeneity of early repolarization and arrhythmogenesis in canine left ventricular myocytes. Am. J. Physiol. Heart Circ. Physiol. 291, H2617鈥揌2629 (2006) CrossRef - 作者单位：Jazmin Aguado-Sierra (19)
Alfonso Santiago (19)
Matias I. Rivero (19)
Mari帽a L贸pez-Yunta (19)
David Soto-Iglesias (20)
Lydia Dux-Santoy (20)
Oscar Camara (20)
Mariano Vazquez (19)
19. Barcelona Supercomputing Centre, Barcelona, Spain
20. PhySense, DTIC, Universitat Pompeu Fabra, Barcelona, Spain - 丛书名：Statistical Atlases and Computational Models of the Heart - Imaging and Modelling Challenges
- ISBN：978-3-319-14678-2
- 刊物类别：Computer Science
- 刊物主题：Artificial Intelligence and Robotics
Computer Communication Networks
Software Engineering
Data Encryption
Database Management
Computation by Abstract Devices
Algorithm Analysis and Problem Complexity - 出版者：Springer Berlin / Heidelberg
- ISSN：1611-3349
文摘
Verification of electro-mechanic models of the heart require a good amount of reliable, high resolution, thorough in-vivo measurements. The detail of the mathematical models used to create simulations of the heart beat vary greatly. Generally, the objective of the simulation determines the modeling approach. However, it is important to exactly quantify the amount of error between the various approaches that can be used to simulate a heart beat by comparing them to ground truth data. The more detailed the model is, the more computing power it requires, we therefore employ a high-performance computing solver throughout this study. We aim to compare models to data measured experimentally to identify the effect of using a mathematical model of fibre orientation versus the measured fibre orientations using DT-MRI. We also use simultaneous endocardial stimuli vs an instantaneous myocardial stimulation to trigger the mechanic contraction. Our results show that synchronisation of the electrical and mechanical events in the heart beat are necessary to create a physiological timing of hemodynamic events. Synchronous activation of all of the myocardium provides an unrealistic timing of hemodynamic events in the cardiac cycle. Results also show the need of establishing a protocol to quantify the zero-pressure configuration of the left ventricular geometry to initiate the simulation protocol; however, the predicted zero-pressure configuration of the same geometry was different, depending on the origin of the fibre field employed.