Intraflagellar transport complex structure and cargo interactions
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  • 作者：Sagar Bhogaraju (5)
    Benjamin D Engel (6)
    Esben Lorentzen (5)
  • 关键词：Intraflagellar transport ; Cilium ; IFT ; IFT complex ; IFT cargo
  • 刊名：Cilia
  • 出版年：2013
  • 出版时间：December 2013
  • 年：2013
  • 卷：2
  • 期：1
  • 全文大小：281 KB
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  • 作者单位：Sagar Bhogaraju (5)
    Benjamin D Engel (6)
    Esben Lorentzen (5)

    5. Department of Structural Cell Biology, Max-Planck-Institute of Biochemistry, Am Klopferspitz 18, Martinsried, D-82152, Germany
    6. Department of Molecular Structural Biology, Max-Planck-Institute of Biochemistry, Am Klopferspitz 18, Martinsried, D-82152, Germany
  • ISSN：2046-2530
文摘
Intraflagellar transport (IFT) is required for the assembly and maintenance of cilia, as well as the proper function of ciliary motility and signaling. IFT is powered by molecular motors that move along the axonemal microtubules, carrying large complexes of IFT proteins that travel together as so-called trains. IFT complexes likely function as adaptors that mediate interactions between anterograde/retrograde motors and ciliary cargoes, facilitating cargo transport between the base and tip of the cilium. Here, we provide an up-to-date review of IFT complex structure and architecture, and discuss how interactions with cargoes and motors may be achieved.

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