Identification of an acetal derivative of the piperonyl methyl ketone in tablets seized for suspected drug trafficking

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• 作者：Jussara Amato (1)
  Nunzia Iaccarino (1)
  Bruno Pagano (1)
  Maria Maglieri (2)
  Guido Persico (2)
  Roberto Russo (1)
  Carmen De Caro (1)
  Antonio Calignano (1)
  Ettore Novellino (1)
  Antonio Randazzo (1)
  
• 关键词：New designer drug ; Piperonyl methyl ketone acetal derivative (PMKA) ; MDMA ; Tablet seized ; GC–MS ; NMR
• 刊名：Forensic Toxicology
• 出版年：2014
• 出版时间：August 2014
• 年：2014
• 卷：32
• 期：2
• 页码：311-316
• 全文大小：495 KB
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• 作者单位：Jussara Amato (1)
  Nunzia Iaccarino (1)
  Bruno Pagano (1)
  Maria Maglieri (2)
  Guido Persico (2)
  Roberto Russo (1)
  Carmen De Caro (1)
  Antonio Calignano (1)
  Ettore Novellino (1)
  Antonio Randazzo (1)
  
  1. Department of Pharmacy, University of Naples “Federico II- via D. Montesano 49, 80131, Naples, Italy
  2. Laboratorio Indagini Chimiche, Gabinetto Interregionale di Polizia Scientifica per Campania e Molise, Naples, Italy
  
• ISSN：1860-8973

文摘

Structural elucidation of a new chemical compound found in tablets seized in the Naples area (Italy) and manufactured in the Netherlands was conducted using nuclear magnetic resonance spectroscopy, gas chromatography–mass spectrometry, and high-resolution mass spectrometry. The compound was identified as the acetal derivative of the piperonyl methyl ketone (PMKA). The structure of PMKA is unprecedented and remarkable for the lack of a nitrogen atom at the distal position of the methylenedioxyphenyl moiety. Surprisingly, PMKA was inactive by itself, but it enhanced the stimulant effects on locomotor activity at the central nervous system level induced by 3,4-methylenedioxymethamphetamine in mice.