Effect of l-carnitine supplementation on the body carnitine pool, skeletal muscle energy metabolism and physical performance in male vegetarians
详细信息    查看全文
  • 作者:Katerina Novakova ; Oliver Kummer ; Jamal Bouitbir…
  • 关键词:Vegetarians ; l ; carnitine supplementation ; Spiroergometry ; Skeletal muscle ; Energy metabolism
  • 刊名:European Journal of Nutrition
  • 出版年:2016
  • 出版时间:February 2016
  • 年:2016
  • 卷:55
  • 期:1
  • 页码:207-217
  • 全文大小:516 KB
  • 参考文献:1.McEvoy CT, Temple N, Woodside JV (2012) Vegetarian diets, low-meat diets and health: a review. Public Health Nutr 15:2287–2294. doi:10.​1017/​s136898001200093​6 CrossRef
    2.Tonstad S, Butler T, Yan R, Fraser GE (2009) Type of vegetarian diet, body weight, and prevalence of type 2 diabetes. Diabetes Care 32:791–796. doi:10.​2337/​dc08-1886 CrossRef
    3.Key TJ, Fraser GE, Thorogood M, Appleby PN, Beral V, Reeves G, Burr ML, Chang-Claude J, Frentzel-Beyme R, Kuzma JW, Mann J, McPherson K (1999) Mortality in vegetarians and nonvegetarians: detailed findings from a collaborative analysis of 5 prospective studies. Am J Clin Nutr 70:516S–524S
    4.Pormsila W, Krahenbuhl S, Hauser PC (2010) Determination of carnitine in food and food supplements by capillary electrophoresis with contactless conductivity detection. Electrophoresis 31:2186–2191. doi:10.​1002/​elps.​200900692 CrossRef
    5.Etzioni A, Levy J, Nitzan M, Erde P, Benderly A (1984) Systemic carnitine deficiency exacerbated by a strict vegetarian diet. Arch Dis Child 59:177–179CrossRef
    6.Lombard KA, Olson AL, Nelson SE, Rebouche CJ (1989) Carnitine status of lactoovovegetarians and strict vegetarian adults and children. Am J Clin Nutr 50:301–306
    7.Rebouche CJ, Lombard KA, Chenard CA (1993) Renal adaptation to dietary carnitine in humans. Am J Clin Nutr 58:660–665
    8.Feller AG, Rudman D (1988) Role of carnitine in human nutrition. J Nutr 118:541–547
    9.Steiber A, Kerner J, Hoppel CL (2004) Carnitine: a nutritional, biosynthetic, and functional perspective. Mol Aspects Med 25:455–473. doi:10.​1016/​j.​mam.​2004.​06.​006 CrossRef
    10.Stephens FB, Marimuthu K, Cheng Y, Patel N, Constantin D, Simpson EJ, Greenhaff PL (2011) Vegetarians have a reduced skeletal muscle carnitine transport capacity. Am J Clin Nutr 94:938–944. doi:10.​3945/​ajcn.​111.​012047 CrossRef
    11.Bremer J (1983) Carnitine—metabolism and functions. Physiol Rev 63:1420–1480
    12.Fritz IB, Marquis NR (1965) The role of acylcarnitine esters and carnitine palmityltransferase in the transport of fatty acyl groups across mitochondrial membranes. Proc Natl Acad Sci USA 54:1226–1233CrossRef
    13.Fritz IB, Mc EB (1959) Effects of carnitine on fatty-acid oxidation by muscle. Science 129:334–335CrossRef
    14.Brass EP, Hoppel CL (1980) Relationship between acid-soluble carnitine and coenzyme A pools in vivo. Biochem J 190:495–504CrossRef
    15.Bieber LL, Emaus R, Valkner K, Farrell S (1982) Possible functions of short-chain and medium-chain carnitine acyltransferases. Fed Proc 41:2858–2862
    16.Childress CC, Sacktor B (1966) Pyruvate oxidation and the permeability of mitochondria from blowfly flight muscle. Science 154:268–270CrossRef
    17.Friolet R, Hoppeler H, Krahenbuhl S (1994) Relationship between the coenzyme A and the carnitine pools in human skeletal muscle at rest and after exhaustive exercise under normoxic and acutely hypoxic conditions. J Clin Invest 94:1490–1495CrossRef
    18.Giamberardino MA, Dragani L, Valente R, Di Lisa F, Saggini R, Vecchiet L (1996) Effects of prolonged l -carnitine administration on delayed muscle pain and CK release after eccentric effort. Int J Sports Med 17:320–324CrossRef
    19.Rubin MR, Volek JS, Gomez AL, Ratamess NA, French DN, Sharman MJ, Kraemer WJ (2001) Safety measures of l -carnitine l -tartrate supplementation in healthy men. J Strength Cond Res 15:486–490
    20.Roberts TJ, Weber JM, Hoppeler H, Weibel ER, Taylor CR (1996) Design of the oxygen and substrate pathways. II. Defining the upper limits of carbohydrate and fat oxidation. J Exp Biol 199:1651–1658
    21.Romijn JA, Coyle EF, Sidossis LS, Gastaldelli A, Horowitz JF, Endert E, Wolfe RR (1993) Regulation of endogenous fat and carbohydrate metabolism in relation to exercise intensity and duration. Am J Physiol 265:E380–E391
    22.Howlett RA, Parolin ML, Dyck DJ, Hultman E, Jones NL, Heigenhauser GJ, Spriet LL (1998) Regulation of skeletal muscle glycogen phosphorylase and PDH at varying exercise power outputs. Am J Physiol 275:R418–R425
    23.Stephens FB, Constantin-Teodosiu D, Greenhaff PL (2007) New insights concerning the role of carnitine in the regulation of fuel metabolism in skeletal muscle. Journal Physiol 581:431–444. doi:10.​1113/​jphysiol.​2006.​125799 CrossRef
    24.Wall BT, Stephens FB, Constantin-Teodosiu D, Marimuthu K, Macdonald IA, Greenhaff PL (2011) Chronic oral ingestion of l -carnitine and carbohydrate increases muscle carnitine content and alters muscle fuel metabolism during exercise in humans. J Physiol 589:963–973. doi:10.​1113/​jphysiol.​2010.​201343 CrossRef
    25.Bergman BC, Brooks GA (1999) Respiratory gas-exchange ratios during graded exercise in fed and fasted trained and untrained men. J Appl Physiol 86:479–487 (Bethesda, Md.: 1985)
    26.Gollnick PD, Karlsson J, Piehl K, Saltin B (1974) Selective glycogen depletion in skeletal muscle fibres of man following sustained contractions. J Physiol 241:59–67CrossRef
    27.Borg GA (1982) Psychophysical bases of perceived exertion. Med Sci Sports Exerc 14:377–381
    28.Bergstrom J (1975) Percutaneous needle biopsy of skeletal muscle in physiological and clinical research. Scand J Clin Lab Invest 35:609–616CrossRef
    29.Harris RC, Hultman E, Nordesjo LO (1974) Glycogen, glycolytic intermediates and high-energy phosphates determined in biopsy samples of musculus quadriceps femoris of man at rest. Methods and variance of values. Scand J Clin Lab Invest 33:109–120CrossRef
    30.Olsen C (1971) An enzymatic fluorimetric micromethod for the determination of acetoacetate, β-hydroxybutyrate, pyruvate and lactate. Clin Chim Acta 33:293–300CrossRef
    31.Mayo Clinic Calorie Calculator. http://​www.​mayoclinic.​org/​calorie-calculator/​itt-20084939 . Accessed 09 Dec 2015
    32.Stephens FB, Wall BT, Marimuthu K, Shannon CE, Constantin-Teodosiu D, Macdonald IA, Greenhaff PL (2013) Skeletal muscle carnitine loading increases energy expenditure, modulates fuel metabolism gene networks and prevents body fat accumulation in humans. J Physiol 591:4655–4666. doi:10.​1113/​jphysiol.​2013.​255364 CrossRef
    33.Tamai I, Ohashi R, Nezu J, Yabuuchi H, Oku A, Shimane M, Sai Y, Tsuji A (1998) Molecular and functional identification of sodium ion-dependent, high affinity human carnitine transporter OCTN2. J Biol Chem 273:20378–20382CrossRef
    34.Schurch R, Todesco L, Novakova K, Mevissen M, Stieger B, Krahenbuhl S (2010) The plasma carnitine concentration regulates renal OCTN2 expression and carnitine transport in rats. Eur J Pharmacol 635:171–176. doi:10.​1016/​j.​ejphar.​2010.​02.​045 CrossRef
    35.Lennon DL, Shrago ER, Madden M, Nagle FJ, Hanson P (1986) Dietary carnitine intake related to skeletal muscle and plasma carnitine concentrations in adult men and women. Am J Clin Nutr 43:234–238
    36.Barnett C, Costill DL, Vukovich MD, Cole KJ, Goodpaster BH, Trappe SW, Fink WJ (1994) Effect of l -carnitine supplementation on muscle and blood carnitine content and lactate accumulation during high-intensity sprint cycling. Int J Sport Nutr 4:280–288
    37.Wachter S, Vogt M, Kreis R, Boesch C, Bigler P, Hoppeler H, Krahenbuhl S (2002) Long-term administration of l -carnitine to humans: effect on skeletal muscle carnitine content and physical performance. Clin Chim Acta 318:51–61CrossRef
    38.Berardi S, Stieger B, Hagenbuch B, Carafoli E, Krahenbuhl S (2000) Characterization of l -carnitine transport into rat skeletal muscle plasma membrane vesicles. Eur J Biochem 267:1985–1994CrossRef
    39.Stephens FB, Constantin-Teodosiu D, Laithwaite D, Simpson EJ, Greenhaff PL (2006) An acute increase in skeletal muscle carnitine content alters fuel metabolism in resting human skeletal muscle. J Clin Endocrinol Metab 91:5013–5018. doi:10.​1210/​jc.​2006-1584 CrossRef
    40.Barr SI, Rideout CA (2004) Nutritional considerations for vegetarian athletes. Nutrition 20:696–703. doi:10.​1016/​j.​nut.​2004.​04.​015 (Burbank, Los Angeles County, Calif.)CrossRef
    41.Venderley AM, Campbell WW (2006) Vegetarian diets: nutritional considerations for athletes. Sports Med 36:293–305 (Auckland, N.Z.)CrossRef
    42.Raben A, Kiens B, Richter EA, Rasmussen LB, Svenstrup B, Micic S, Bennett P (1992) Serum sex hormones and endurance performance after a lacto-ovo vegetarian and a mixed diet. Med Sci Sports Exerc 24:1290–1297CrossRef
  • 作者单位:Katerina Novakova (1) (2)
    Oliver Kummer (1) (2)
    Jamal Bouitbir (1) (2)
    Sonja D. Stoffel (1)
    Ulrike Hoerler-Koerner (1)
    Michael Bodmer (1) (2)
    Paul Roberts (1) (2)
    Albert Urwyler (3)
    Rolf Ehrsam (1)
    Stephan Krähenbühl (1) (2)

    1. Division of Clinical Pharmacology and Toxicology, University Hospital Basel, CH-4031, Basel, Switzerland
    2. Department of Biomedicine, University of Basel, Basel, Switzerland
    3. Department of Anesthesia, University Hospital Basel, Basel, Switzerland
  • 刊物类别:Chemistry and Materials Science
  • 刊物主题:Chemistry
    Nutrition
  • 出版者:Springer Berlin / Heidelberg
  • ISSN:1436-6215
文摘
Purpose More than 95 % of the body carnitine is located in skeletal muscle, where it is essential for energy metabolism. Vegetarians ingest less carnitine and carnitine precursors and have lower plasma carnitine concentrations than omnivores. Principle aims of the current study were to assess the plasma and skeletal muscle carnitine content and physical performance of male vegetarians and matched omnivores under basal conditions and after l-carnitine supplementation.

© 2004-2018 中国地质图书馆版权所有 京ICP备05064691号 京公网安备11010802017129号

地址:北京市海淀区学院路29号 邮编:100083

电话:办公室:(+86 10)66554848;文献借阅、咨询服务、科技查新:66554700