Oral manifestations of hereditary nonpolyposis colorectal cancer syndrome: a family case series

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• 作者：Fabiana Tolentino Almeida (10)
  Raquel Ribeiro Gomes (10)
  Andr茅 Ferreira Leite (10)
  Jo茫o Batista Sousa (11)
  Ana Carolina Acevedo (10)
  Eliete Neves Silva Guerra (10)
  
  10. Oral Care Center for Inherited Diseases ; Division of Dentistry at University Hospital of Brasilia ; Faculty of Health Sciences ; University of Brasilia (UNB) ; Brasilia ; Brazil
  11. Coloproctology Division ; University Hospital of Brasilia ; Faculty of Medicine ; University of Brasilia (UNB) ; Brasilia ; Brazil
  
• 关键词：Dento ; osseous anomalies ; Fordyce granules ; Hereditary nonpolyposis colorectal cancer
• 刊名：Journal of Medical Case Reports
• 出版年：2014
• 出版时间：December 2014
• 年：2014
• 卷：8
• 期：1
• 全文大小：513 KB
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• 刊物主题：Medicine/Public Health, general; General Practice / Family Medicine; Public Health; Primary Care Medicine;
• 出版者：BioMed Central
• ISSN：1752-1947

文摘

Introduction Hereditary nonpolyposis colorectal cancer is a colorectal cancer syndrome characterized by the development of colorectal cancer and extracolonic tumors, and this syndrome has an autosomal dominant mode of inheritance. To our knowledge, our study was the first to find dento-osseous anomalies and the second to observe Fordyce granules in a family with individuals with hereditary nonpolyposis colorectal cancer. Case presentations Twenty members of one Brazilian family with individuals with hereditary nonpolyposis colorectal cancer were analyzed according to the presence of colorectal cancer and the occurrence of Fordyce granules and dento-osseous anomalies. Their average age was 29.6 (range 7 to 53 years) years. Medical examinations of this family with hereditary nonpolyposis colorectal cancer were performed at the Coloproctology Division of our hospital. Then, all individuals were referred to our Oral Care Center for Inherited Diseases for intraoral examinations to verify the presence of Fordyce granules. Dental panoramic radiographs were done in order to describe dento-osseous anomalies on applying the Dental Panoramic Radiograph System. Of the 20 family members, four were diagnosed with hereditary nonpolyposis colorectal cancer and all four presented Fordyce granules in their upper lip, but only one of these four patients (Case 2) had a significant dento-osseous anomaly. Conclusions Our familial study verified the presence of Fordyce granules in all individuals diagnosed with hereditary nonpolyposis colorectal cancer, and the presence of significant dento-osseous anomalies in one of these cases. However, the relationship between oral manifestations and hereditary nonpolyposis colorectal cancer should be further investigated.