Intraductal Polypoid Lipid-Rich Neuroendocrine Tumor of the Pancreas with Entrapped Ductules: Case Report and Review of the Literature

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• 作者：Jaclyn Frances Hechtman (1)
  Bernardo Franssen (2)
  Daniel M. Labow (2)
  Ronald E. Gordon (1)
  Christopher J. DiMaio (3)
  Eric J. Wilck (4)
  Gonzalo Carrasco-Avino (1)
  Hongfa Zhu (1)
  
• 关键词：Neuroendocrine tumor ; Carcinoid ; Lipid rich ; Clear cell ; Ductulo ; insular ; Entrapped glands ; CK19 ; Intraductal ; Polypoid ; Pancreas ; Pancreatic
• 刊名：Endocrine Pathology
• 出版年：2013
• 出版时间：March 2013
• 年：2013
• 卷：24
• 期：1
• 页码：30-35
• 全文大小：512KB
• 参考文献：1. Albores-Saavedra J, Henson D, Klimstra D. Tumors of the gallbladder, extrahepatic biliary ducts and ampulla of vater. AFIP Atlas of Tumor Pathology, 3rd ser. Washington, DC: Armed Forces Institute of Pathology, 2000.
  2. Walter T, Hervieu V, Adham M, et al. Primary neuroendocrine tumors of the main pancreatic duct: a rare entity. / Virchows Arch 2011;458(5):537-46. CrossRef
  3. Nagai E, Yamaguchi K, Hashimoto H, Sakurai T. Carcinoid tumor of the pancreas with obstructive pancreatitis. / Am J Gastroenterol 1993;87:361-64.
  4. Dei Tos AP, Laurino L, De Boni M, Doglioni C. Preoperative cytodiagnosis of primitive carcinoid tumor of the Wirsung duct: a case report with immunocytochemical study. / Diagn Cytopathol 1993;9:471-74. CrossRef
  5. Sarles H, Cambon P, Choux R, et al. Chronic obstructive pancreatitis due to tiny (0.6 to 8?mm) benign tumors obstructing pancreatic ducts: report of three cases. / Pancreas 1988;3:232-37. CrossRef
  6. Kim HC, Park SI, Park SJ, et al. Pancreatic carcinoid tumor with obstructive pancreatitis: multislice helical CT appearance: case report. / Abdom Imaging 2005;30:601-04 CrossRef
  7. Hamada Y, Nakayama Y, Maeshiro K, Ikeda T, Hayashi H, Iwasaki H. Two cases of primary carcinoid tumor of the pancreas associated with marked stenosis of the main pancreatic duct. / Pancreas 2009;38:834-35. CrossRef
  8. Terada T, Kawaguchi M, Furukawa K, Sekido Y, Osamura Y. Minute mixed ductal-endocrine carcinoma of the pancreas with predominant intraductal growth. / Pathol Int 2002;52(11):740-46. CrossRef
  9. Chetty R, El-Shinnawy I. Intraductal pancreatic neuroendocrine tumor. / Endocr Pathol 2009;20(4):262-66. CrossRef
  10. Maitra A, Krueger JE, Tascilar M, et al. Carcinoid tumors of the extrahepatic bile ducts: a study of seven cases. / Am J Surg Pathol 2000;24(11):1501-510. CrossRef
  11. Lee JH, Lee KG, Oh YH, Paik SS, Park HK, Lee KS. Carcinoid tumors of the extrahepatic biliary tract: report of four cases. / Surg Today 2011;41(3):430-35. CrossRef
  12. Dahms BB, Lippe BM, Dakake C, Fonkalsrud EW, Mirra JM. The occurrence in a neonate of a pancreatic adenoma with nesidioblastosis in the tumor. / Am J Clin Pathol 1976;65(4):462-66.
  13. Van Eeden S, de Leng WW, Offerhaus GJ, et al. Ductuloinsular tumors of the pancreas: endocrine tumors with entrapped non neoplastic ductules. / Am J Surg Pathol 2004;28(6):813-20. CrossRef
  14. Chetty R, Serra S, Asa SL, Adsay VN. Pancreatic endocrine tumour with ductules: further observations of an unusual histological subtype. / Pathology 2006;38(1):5-. CrossRef
  15. Singh R, Basturk O, Klimstra DS, et al. Lipid-rich variant of pancreatic endocrine neoplasms. / Am J Surg Pathol 2006;30(2):194-00. CrossRef
  16. Lubensky IA, Pack S, Ault D, et al. Multiple neuroendocrine tumors of the pancreas in von Hippel–Lindau disease. / Am J Pathol 1998;153:223-31. CrossRef
  17. Fryer E, Serra S, Chetty R. Lipid-rich ("clear cell") neuroendocrine tumors of the pancreas in MEN I patients. / Endocr Pathol 2012; 23(4):243-46 CrossRef
  18. Chetty R, Serra S. Lipid-rich and clear cell neuroendocrine tumors (“carcinoid- of the appendix: potential confusion with goblet cell carcinoid. / Am J Surg Pathol 2010;34:401-04. CrossRef
  19. Carlei F, Barsotti P, Crescenzi A, et al. Neuroendocrine epithelial cells of the main pancreatic ducts and ampulla. / Ital J Gastroenterol 1993;25:171-73.
  20. McCall CM, Shi C, Klein AP, et al. Serotonin expression in pancreatic neuroendocrine tumors correlates with a trabecular histologic pattern and large duct involvement. / Hum Pathol 2012;43(8):1169-176. CrossRef
  21. Schmitt AM, Anlauf M, Rousson V, et al. WHO 2004 criteria and CK19 are reliable prognostic markers in pancreatic endocrine tumors. / Am J Surg Pathol 2007;31(11):1677-682. CrossRef
  22. Ali A, Serra S, Asa SL, Chetty R. The predictive value of CK19 and CD99 in pancreatic endocrine tumors. / Am J Surg Pathol 2006;30(12):1588-94. CrossRef
  23. Zhang L, Lohse CM, Dao LN, Smyrk TC. Proposed histopathologic grading system derived from a study of KIT and CK19 expression in pancreatic endocrine neoplasm. / Hum Pathol 2011;42(3):324-31. CrossRef
  24. Li J, Goodyer CG, Fellows F, et al. Stem cell factor/c-Kit interactions regulate human islet-epithelial cluster proliferation and differentiation. / Int J Biochem Cell Biol 2006;38:961-72. CrossRef
  25. Barron-Rodriguez LP, Manivel JC, Mendez-Sanchez N, Jessurun J. Carcinoid tumor of the common bile duct: evidence for its origin in metaplastic endocrine cells. / Am J Gastroenterol 1991;86:1073-106.
  
• 作者单位：Jaclyn Frances Hechtman (1)
  Bernardo Franssen (2)
  Daniel M. Labow (2)
  Ronald E. Gordon (1)
  Christopher J. DiMaio (3)
  Eric J. Wilck (4)
  Gonzalo Carrasco-Avino (1)
  Hongfa Zhu (1)
  
  1. Department of Pathology, Mount Sinai School of Medicine, One Gustave L Levy Place, 1194, New York, NY, 10029, USA
  2. Division of Surgical Oncology, Mount Sinai School of Medicine, New York, NY, USA
  3. Division of Gastroenterology, Mount Sinai School of Medicine, New York, NY, USA
  4. Department of Radiology, Mount Sinai School of Medicine, New York, NY, USA
  

文摘

Pancreatic neuroendocrine tumors of the main pancreatic duct are rare and usually small due to symptoms of pancreatic duct obstruction. We present a case of a large (3?cm), well-differentiated (G1) lipid-rich polypoid neuroendocrine tumor of the pancreas completely occluding the main pancreatic duct with non-neoplastic-entrapped ductules and CK19 positivity. Clinical, radiological, gross, microscopic, immunohistochemical, and ultrastructural findings are discussed. The literature pertaining to the unique features of this case is reviewed including clinical and pathologic pitfalls and the possible etiologic and prognostic significance of these findings.