Vaccination prepartum enhances the beneficial effects of melatonin on the immune response and reduces platelet responsiveness in sheep

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• 作者：Sergio Regodón (1)
  Asunción Ramos (1)
  María P Míguez (2)
  Antonio Carrillo-Vico (3)
  Juan A Rosado (4)
  Isaac Jardín (4)
  
• 关键词：Clostridium perfringens ; Immune response to vaccination ; Melatonine ; Platelet aggregation ; Pregnant sheep
• 刊名：BMC Veterinary Research
• 出版年：2012
• 出版时间：December 2012
• 年：2012
• 卷：8
• 期：1
• 全文大小：283KB
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• 作者单位：Sergio Regodón (1)
  Asunción Ramos (1)
  María P Míguez (2)
  Antonio Carrillo-Vico (3)
  Juan A Rosado (4)
  Isaac Jardín (4)
  
  1. Department of Animal Medicine, University of Extremadura, 10003, Cáceres, Spain
  2. Department of Animal Health, University of Extremadura, 10003, Cáceres, Spain
  3. Deparment of Medical Biochemistry and Molecular Biology, University of Sevilla School of Medicine, 41004, Sevilla, Spain
  4. Department of Physiology (Cell Physiology Research Group), University of Extremadura, 10003, Cáceres, Spain
  

文摘

Background Melatonin regulates several physiological processes and its powerful action as antioxidant has been widely reported. Melatonin acts modulating the immune system, showing a protective effect on the cardiovascular system and improving vaccine administration as an adjuvant-like agent. Here, we have investigated the role of melatonin as an adjuvant of the Clostridium perfringens vaccine in prepartum sheep and whether melatonin modulates platelet physiology during peripartum. Results The experiments were carried out in peripartum sheep from a farm located in an area of Mediterranean-type ecosystem. Plasma melatonin levels were determined by ELISA and sheep platelet aggregation was monitored using an aggregometer. Here we demonstrated for the first time that plasma melatonin concentration were higher in pregnant (125?pg/mL) than in non-pregnant sheep (15?pg/mL; P-lt;-.05). Administration of melatonin prepartum did not significantly modify platelet function but significantly improved the immune response to vaccination against C. perfringens. Conclusion Administration of melatonin as an adjuvant provides a significant improvement in the immune response to vaccine administration prepartum against C. perfringens.