Dependence of optical attenuation coefficient and mechanical tension of irradiated human cartilage measured by optical coherence tomography
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  • 作者:A. C. Martinho Junior (1)
    A. Z. Freitas (1)
    M. P. Raele (1)
    S. P. Santin (1)
    F. A. N. Soares (1)
    M. R. Herson (2)
    M. B. Mathor (1)
  • 关键词:Cartilage ; Biomechanical ; Optical coherence tomography
  • 刊名:Cell and Tissue Banking
  • 出版年:2015
  • 出版时间:March 2015
  • 年:2015
  • 卷:16
  • 期:1
  • 页码:47-53
  • 全文大小:557 KB
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  • 作者单位:A. C. Martinho Junior (1)
    A. Z. Freitas (1)
    M. P. Raele (1)
    S. P. Santin (1)
    F. A. N. Soares (1)
    M. R. Herson (2)
    M. B. Mathor (1)

    1. Instituto de Pesquisas Energ茅ticas e Nucleares (Ipen/CNEN-SP), S茫o Paulo, Brazil
    2. The Alfred Skin Cell Culture Laboratory, Monash University, Melbourne, Australia
  • 刊物类别:Biomedical and Life Sciences
  • 刊物主题:Life Sciences
    Cell Biology
    Biomedicine
    Transplant Surgery
  • 出版者:Springer Netherlands
  • ISSN:1573-6814
文摘
As banked human tissues are not widely available, the development of new non-destructive and contactless techniques to evaluate the quality of allografts before distribution for transplantation is very important. Also, tissues will be processed accordingly to standard procedures and to minimize disease transmission most tissue banks will include a decontamination or sterilization step such as ionizing radiation. In this work, we present a new method to evaluate the internal structure of frozen or glycerol-processed human cartilages, submitted to various dosis of irradiation, using the total optical attenuation coefficient retrieved from optical coherence tomography (OCT) images. Our results show a close relationship between tensile properties and the total optical attenuation coefficient of cartilages. Therefore, OCT associated with the total optical attenuation coefficient open a new window to evaluate quantitatively biological changes in processed tissues.

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