Effect of different stages of Schistosoma mansoni infection on the parasite burden and immune response to Strongyloides venezuelensis in co-infected mice

详细信息    查看全文

• 作者：Michelle Carvalho de Rezende ; Emília Souza Araújo…
• 关键词：Schistosoma mansoni ; Strongyloides venezuelensis ; Co ; infection ; Cross ; reactive antibody production ; Tissue eosinophilia
• 刊名：Parasitology Research
• 出版年：2015
• 出版时间：December 2015
• 年：2015
• 卷：114
• 期：12
• 页码：4601-4616
• 全文大小：2,273 KB
• 参考文献：Abruzzi A, Fried B (2011) Coinfection of Schistosoma (Trematoda) with bacteria, protozoa and helminthes. Adv Parasitol 77:1-5CrossRef PubMed
  Belkaid Y, Blank RB, Suffia I (2006) Natural regulatory T cells and parasites: a common quest for host homeostasis. Immunol Rev 212:287-00CrossRef PubMed
  Bonne-Année S, Hess Já, Abraham D (2011) Innate and adaptive immunity to the nematode Strongyloides stercoralis in a mouse model. Immunol Res 51:205-14CrossRef PubMed
  Boros DL, Warren KS (1970) Delayed hypersensitivity-type granuloma formation and dermal reaction induced and elicited by a soluble factor isolated from Schistosoma mansoni eggs. J Exp Med 132:488-07PubMed Central CrossRef PubMed
  Bradley SL, Dines DE, Brewer NS (1978) Disseminated Strongyloides stercoralis in immunosuppressed host. Mayo Clin Proc 53:332-35PubMed
  Brigandi RA, Rotman HL, Yutanawiboonchai W, Leon O, Nolan TJ, Schad GA, Abraham D (1996) Strongyloides stercoralis: role of antibody and complement in immunity to the third stage of larvae in BALB/cByJ mice. Exp Parasitol 82:279-89CrossRef PubMed
  Burke ML, Jones MK, Gobert GN, Li YS, Ellis MK, McManus DP (2009) Immunopathogenesis of human schistosomiasis. Parasite Immunol 31:163-76CrossRef PubMed
  Carvalho EM, Da Fonseca PA (2004) Epidemiological and clinical interaction between HTLV-1 and Strongyloides stercoralis. Parasite Immunol 26:487-97CrossRef PubMed
  Concha AR, Harrington W Jr, Rogers AI (2005) Intestinal strongyloidiasis: recognition, management, and determinants of outcome. J Clin Gasteoenterol 39:203-11CrossRef
  Corrêa-Oliveira R, Golgher DB, Oliveira GC, Carvalho OS, Massara CL, Caldas IR, Colley DG, Gazzinelli G (2002) Infection with Schistosoma mansoni correlates with altered immune responses to Ascaris lumbricoides and hookworm. Acta Trop 83:123-32CrossRef PubMed
  Curry AJ, Else KJ, Jones F, Bancroft A, Grencis RK, Dunne DW (1995) Evidence that cytokines-mediated immune interations induced by Schistosoma mansoni alter disease outcome in mice concurrently infected with Trichuris muris. J Exp Med 181:769-74CrossRef PubMed
  De Jesus AR, Silva A, Santana LB, Magalh?es A, de Jesus AA, de Almeida RP, Rêgo MA, Burattini MN, Pearce EJ, Carvalho EM (2002) Clinical and immunologic evaluation of 31 patients with acute schistosomiasis mansoni. J Infect Dis 185:98-05CrossRef PubMed
  de Silva NR, Brooker S, Hotez PJ, Montresor A, Engles D, Saviole L (2003) Soil-transmitted helminth infection: updating the global picture. Trends Parasitol 19:547-51CrossRef PubMed
  Dunne DW, Pearce EJ (1999) Immunology of hepatosplenic schistosomiasis mansoni: a human perspective. Microbes Infect 1:533-60CrossRef
  El-Malky M, Maruyama H, Hirabayashi Y, Shimada S, Yoshida A, Amano T, Tominaga A, Takatsu K, Ohta N (2003) Intraepithelial infiltration of eosinophils and their contribution to the elimination of adult intestinal nematode, Strongyloides venezuelensis in mice. Parasitol Int 52:71-9CrossRef PubMed
  Fairfax BP, Makino S, Radhakrishnan J, Plant K, Leslie S, Dilthey A, Ellis P, Langford C, Vannberg FO, Knight JC (2012) Genetics of gene expression in primary immune cells identifies cell type-specific master regulators and roles of HLA alleles. Nat Genet 44:502-10PubMed Central CrossRef PubMed
  Fallon PG, Smith P, Dunne DW (1998) Type 1 and type 2 cytokine-producing mouse CD4+ and CD8+ T cells in acute Schistosoma mansoni infection. Eur J Immunol 28:1408-416CrossRef PubMed
  Fallon PG, Richardson EJ, McKenzie GJ, McKenzie AN (2000) Schistosome infection of transgenic mice defines distinct and contrasting pathogenic roles for IL-4 and IL-13: IL-13 is a profibrotic agent. J Immunol 164:2585-591CrossRef PubMed
  Fernandes A, Pereira ATM, Eechenazi PD, Schilter HC, Sousa ALS, Teixeira MM, Negr?o-Corrêa D (2008) Evaluation of the immune response against Strongyloides venezuelensis in antigen-immunized or previously infected mice. Parasite Immunol 30:139-49CrossRef PubMed
  Fleming FM, Brooker S, Geiger SM, Caldas IR, Corrêa-Oliveira R, Hotez PJ, Bethony JM (2006) Synergistic associations between hookworm and other helminth species in rural community in Brazil. Trop Med Int Health 11:56-4CrossRef PubMed
  Gazzinelli SEP, Melo AL (2008) Intera??o entre Strongyloides venezuelensis e Schistosoma mansoni em camundongos da linhagem AKR/J. Rev Cienc Med Biol 7:149-55
  Genta RM (1989) Global prevalence of strongyloidiasis: critical review with epidemiologic insights into the prevention of disseminated disease. Rev Infect Dis 11:755-67CrossRef PubMed
  Gryseels B, Polman K, Clerinx J, Kestens L (2006) Human schistosomiasis. Lancet 368:1106-118CrossRef PubMed
  Gryseels B (2012) Schistosomiasis. Infect Dis Clin North Am 26:383-97CrossRef PubMed
  He YX, Salafsky B, Ramaswamy K (2005) Comparison of skin invasion among three major species of Schistosoma. Trends Parasitol 21:201-03CrossRef PubMed
  Herbert DR, Lee JJ, Lee NA, Nolan TJ
• 作者单位：Michelle Carvalho de Rezende (1)
  Emília Souza Araújo (1)
  Jo?o Marcelo Peixoto Moreira (1)
  Vanessa Fernandes Rodrigues (1)
  Jailza Lima Rodrigues (1)
  Cíntia A. de Jesus Pereira (1)
  Deborah Negr?o-Corrêa (1)
  
  1. Department of Parasitology, Institute of Biological Science, Federal University of Minas Gerais (UFMG), Block Q3-room 242, Antonio Carlos Avenue 6627, Campus Pampulha, Belo Horizonte, MG, 31270-901, Brazil
  
• 刊物类别：Biomedical and Life Sciences
• 刊物主题：Biomedicine
  Medical Microbiology
  Microbiology
  Immunology
  
• 出版者：Springer Berlin / Heidelberg
• ISSN：1432-1955

文摘

Multiple schistosome and soil-transmitted nematode infections are frequently reported in human populations living in tropical areas of developing countries. In addition to exposure factors, the host immune response plays an important role in helminth control and morbidity in hosts with multiple infections; however, these aspects are difficult to evaluate in human populations. In the current study, female Swiss mice were simultaneously co-infected with Strongyloides venezuelensis and Schistosoma mansoni or infected with St. venezuelensis at 2, 4, or 14 weeks after Sc. mansoni infection. The simultaneously infected mice showed a similar parasite burden for St. venezuelensis compared with mono-infected mice. In contrast, there was a significant reduction of St. venezuelensis burden (primarily during the migration of the larvae) in mice that were previously infected with Sc. mansoni at the acute or chronic phase. Independent of the stage of Sc. mansoni infection, the St. venezuelensis co-infection was capable of inducing IL-4 production in the small intestine, increasing the IgE concentration in the serum and increasing eosinophilia in the lungs and intestine. This result suggests that the nematode infection stimulates local type 2 immune responses independently of the schistosomiasis stage. Moreover, previous Sc. mansoni infection stimulated early granulocyte infiltration in the lungs and trematode-specific IgM and IgG1 production that recognized antigens from St. venezuelensis infective larvae; these immune responses would act in the early control of St. venezuelensis larvae. Our data suggest that the effect of multiple helminth infections on host susceptibility and morbidity largely depends on the species of parasite and the immune response. Keywords Schistosoma mansoni Strongyloides venezuelensis Co-infection Cross-reactive antibody production Tissue eosinophilia