Cyane-carvone, a Synthetic Derivative of Carvone, Inhibits Inflammatory Response by Reducing Cytokine Production and Oxidative Stress and Shows Antinociceptive Effect in Mice
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- 作者：Thiago Henrique Costa Marques (1)
Maria Leonildes Boavista Gomes Castelo Branco Marques (1)
Jand-Venes R. Medeiros (2)
Renan Oliveira Silva (2)
André Luiz dos Reis Barbosa (2)
Tamires Cardoso Lima (3)
Dami?o Pergentino de Sousa (4)
Rivelilson Mendes de Freitas (1) - 关键词：anti ; inflammatory ; antinociceptive ; cyane ; carvone ; mice
- 刊名：Inflammation
- 出版年：2014
- 出版时间：June 2014
- 年：2014
- 卷：37
- 期：3
- 页码：966-977
- 全文大小：
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Maria Leonildes Boavista Gomes Castelo Branco Marques (1)
Jand-Venes R. Medeiros (2)
Renan Oliveira Silva (2)
André Luiz dos Reis Barbosa (2)
Tamires Cardoso Lima (3)
Dami?o Pergentino de Sousa (4)
Rivelilson Mendes de Freitas (1)
1. Laboratório de Pesquisa em Neuroquímica Experimental, Curso de Farmácia, Universidade Federal do Piauí, Campus Universitário Ministro Petr?nio Portella, Bairro Ininga, 64049-550, Teresina, Piauí, Brazil
2. Laboratory of Experimental Physiopharmacology, Biotechnology and Biodiversity Center Research (BIOTEC), Federal University of Piauí (UFPI), Campus of Parnaíba, 64202-020, Parnaíba, PI, Brazil
3. Post-Graduate Program in Pharmaceutics Sciences, Federal University of Sergipe, 49100-000, S?o Cristóv?o, SE, Brazil
4. Department of Pharmaceutical Science, Federal University of Paraiba, University Campus I, Castelo Branco District, 58051-900, Jo?o Pessoa, PB, Brazil - ISSN：1573-2576
文摘
Cyane-carvone (CC) was studied to elucidate its anti-inflammatory, antinociceptive, and antioxidant effects in Mus musculus. Anti-inflammatory (bradykinin, histamine, prostaglandin E2, serotonin, and carrageenan) and antinociceptive (acetic acid and formalin) models were utilized. Myeloperoxidase activity, interleukin (IL)-1β, tumor necrosis factor alpha (TNF-α), and glutathione (GSH) levels were evaluated. Analysis of variance followed by Student-Newman-Keuls-test was done. Results were compared with control groups (significantly when p-lt;-.05). In bradykinin, histamine, prostaglandin E2, and serotonin tests, 75?mg/kg CC decreased significantly paw edema (t--0, 60, 90, and/or 120?min). In carrageenan test, 50 and 75?mg/kg CC (t--?h and t--?h) and 25?mg/kg CC (t--?h) decreased significantly paw edema. CC (75?mg/kg) inhibited significantly mieloperoxidase activity and decreased IL-1β and TNF-α, and all doses increased GSH levels. CC (75?mg/kg) decreased significantly the number of contortions of animals and time of licking (phase 2). CC showed anti-inflammatory, antinociceptive, and antioxidant effects in mice.