Lack of kinin B1 receptor potentiates leptin action in the liver

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• 作者：Raphael Gomes Fonseca (1)
  Vicencia Micheline Sales (1)
  Eduardo Ropelle (2)
  Carlos Castilho Barros (1)
  Lila Oyama (3)
  Silvia Saiuli Iuki Ihara (4)
  Mário Jose Abdalla Saad (5)
  Ronaldo Carvalho Araújo (1)
  Jo?o Bosco Pesquero (1)
  
• 关键词：Kinins ; Liver ; Leptin ; Insulin ; Non ; alcoholic fatty liver disease
• 刊名：Journal of Molecular Medicine
• 出版年：2013
• 出版时间：July 2013
• 年：2013
• 卷：91
• 期：7
• 页码：851-860
• 全文大小：573KB
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• 作者单位：Raphael Gomes Fonseca (1)
  Vicencia Micheline Sales (1)
  Eduardo Ropelle (2)
  Carlos Castilho Barros (1)
  Lila Oyama (3)
  Silvia Saiuli Iuki Ihara (4)
  Mário Jose Abdalla Saad (5)
  Ronaldo Carvalho Araújo (1)
  Jo?o Bosco Pesquero (1)
  
  1. Department of Biophysics, Federal University of S?o Paulo—UNIFESP/EPM, Rua Pedro de Toledo, 669, 9° andar, Vila Clementino, 04039-032, S?o Paulo, S?o Paulo, Brazil
  2. School of Applied Science, State University of Campinas—UNICAMP, Limeira, S?o Paulo, Brazil
  3. Department of Physiology, Federal University of S?o Paulo—UNIFESP/EPM, S?o Paulo, S?o Paulo, Brazil
  4. Department of Pathology, Federal University of S?o Paulo—UNIFESP/EPM, S?o Paulo, S?o Paulo, Brazil
  5. Department of Internal Medicine, State University of Campinas—UNICAMP, Campinas, S?o Paulo, Brazil
  

文摘

Kinins B1 and B2 receptors (B1R and B2R) are classically associated with inflammation, but our group has recently demonstrated new roles for B1R in metabolism using a knockout model (B1 ??/sup>). B1 ??/sup> mice display improvement on leptin and insulin sensitivity and is protected from high fat diet (HFD)-induced obesity. Here, we evaluate the hepatic effects of the B1R ablation and its role on hepatic function. Despite no expression of hepatic B1R, HFD-induced hepatic lipid accumulation was lower than in control animals. B1 ??/sup> mice also presented lower hepatic lipogenesis and SCD1 protein content in the liver. When stimulated with exogenous leptin, B1 ??/sup> mice exhibited increased hepatic pJAK2. Similarly, leptin signaling was enhanced in the liver of ob/ob–B1 ??/sup> mice, as demonstrated by increased levels of pSTAT3 compared to ob/ob. Plasma concentrations of intercellular adhesion molecule 1, fetuin A, leukemia inhibitory factor, tissue inhibitor of metalloprotease-1, resistin, and oncostatin M were reduced in B1 ??/sup>. Finally, B1 ??/sup> mice have increased gene expression of hepatic B2 receptor, but no difference in leptin receptor expression. Our results show that B1 ??/sup> mice are protected from non-alcoholic fatty liver disease (NAFLD) after HFD treatment. Since B1R expression was not observed in the liver after HFD, we propose that the cross talk between the adipose tissue and the liver, mainly through leptin, is an important factor contributing to the observed results. Besides that, several other inflammatory mediators already correlated with NAFLD or liver function were found to be altered in our model. Taken together, our data suggest that B1R plays an important role in hepatic steatosis development.