Albendazole and its derivative JVG9 induce encystation on Giardia intestinalis trophozoites

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• 作者：Armando Pérez-Rangel (2)
  José Manuel Hernández (2)
  Araceli Castillo-Romero (1)
  Lilián Yépez-Mulia (3)
  Rafael Castillo (4)
  Francisco Hernández-Luis (4)
  Benjamín Nogueda-Torres (5)
  Juan Pedro Luna-Arias (2)
  Gerardo Radilla (1)
  Gloria León-Avila (1)
  
• 刊名：Parasitology Research
• 出版年：2013
• 出版时间：September 2013
• 年：2013
• 卷：112
• 期：9
• 页码：3251-3257
• 全文大小：418KB
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• 作者单位：Armando Pérez-Rangel (2)
  José Manuel Hernández (2)
  Araceli Castillo-Romero (1)
  Lilián Yépez-Mulia (3)
  Rafael Castillo (4)
  Francisco Hernández-Luis (4)
  Benjamín Nogueda-Torres (5)
  Juan Pedro Luna-Arias (2)
  Gerardo Radilla (1)
  Gloria León-Avila (1)
  
  2. Departamento de Biología Celular, Centro de Investigación y Estudios Avanzados del Instituto Politécnico Nacional, Av. IPN 2508, Col. San Pedro Zacatenco, 07360, México D.F., Mexico
  1. Departamento de Zoología, Escuela Nacional de Ciencias Biológicas, Instituto Politécnico Nacional, Carpio y Plan de Ayala, Col. Casco de Santo Tomás, 11340, México D.F., Mexico
  3. UMAE Hospital de Pediatría, Centro Médico Nacional Siglo XXI (CMN-SXXI), Instituto Mexicano del Seguro Social (IMSS), 2° piso, 06720, México D.F., Mexico
  4. Departamento de Farmacia, Facultad de Química, Universidad Nacional Autónoma de México, 04510, México D.F., Mexico
  5. Departamento de Parasitología, Escuela Nacional de Ciencias Biológicas, Instituto Politécnico Nacional, Carpio y Plan de Ayala, Col. Casco de Santo Tomás, 11340, México D.F., Mexico
  

文摘

In the present study, we evaluated the effect of an albendazole (ABZ) derivative JVG9 on cultured Giardia intestinalis. To assess the JVG9 effects, we evaluated the tubulin cytoskeleton by confocal microscopy, and we found that the characteristic staining was modified. The scanning electron microscopy images revealed extremely damaged trophozoites and cyst-like cells. The confocal images revealed that this drug triggered the expression of cyst wall protein 1 and encystation. We also found that at low doses, AL triggered the encystation process too.