Prophylactic and therapeutic DNA vaccines against Chagas disease

详细信息    查看全文

• 作者：Minerva Arce-Fonseca (1)
  Martha Rios-Castro (1)
  Silvia del Carmen Carrillo-S谩nchez (1)
  Mariana Mart铆nez-Cruz (1)
  Olivia Rodr铆guez-Morales (1)
  
  1. Department of Molecular Biology ; Laboratory of Molecular Immunology and Proteomics. Instituto Nacional de Cardiolog铆a 鈥淚gnacio Ch谩vez鈥? Juan Badiano No. 1 ; Col. Secci贸n XVI ; Tlalpan ; C.P. 14080 ; Mexico City ; Mexico
  
• 关键词：Chagas disease ; Trypanosoma cruzi ; DNA vaccines
• 刊名：Parasites & Vectors
• 出版年：2015
• 出版时间：December 2015
• 年：2015
• 卷：8
• 期：1
• 全文大小：376 KB
• 参考文献：1. World Health Organization. Weekly epidemiological record. Geneve, Switzerland 2012;87:509-26. Available from: http://www.who.int/wer
  2. Viotti, R, Vigliano, C, Armenti, H, Segura, E (1994) Treatment of chronic Chagas' disease with benznidazole: clinical and serologic evolution of patients with long-term follow-up. Am Heart J 127: pp. 151-62 CrossRef
  3. Murcia, L, Carrilero, B, Segovia, M (2012) Limitations of currently available Chagas disease chemotherapy. Rev Esp Quimioter 25: pp. 1-3
  4. Astelbauer, F, Walochnik, J (2011) Antiprotozoal compounds: state of the art and new developments. Int J Antimicrob Agents 38: pp. 118-24 CrossRef
  5. Urbina, JA, Docampo, R (2003) Specific chemotherapy of Chagas disease: controversies and advances. Trends Parasitol 19: pp. 495-501 CrossRef
  6. Dumonteil, E (2007) DNA vaccines against protozoan parasites: opportunities and challenges. J Biomed Biotechnol 2007: pp. 90520 CrossRef
  7. Smirlis, D, Soares, MB (2014) Selection of molecular targets for drug development against trypanosomatids. Subcell Biochem 74: pp. 43-76 CrossRef
  8. Soeiro, MN, Werbovetz, K, Boykin, DW, Wilson, WD, Wang, MZ, Hemphill, A (2013) Novel amidines and analogues as promising agents against intracellular parasites: a systematic review. Parasitology 140: pp. 929-51 CrossRef
  9. Montgomery, DL, Ulmer, JB, Donnelly, JJ, Liu, MA (1997) DNA Vaccines. Pharmacol Ther 74: pp. 195-205
  10. Coban, C, Kobiyama, K, Aoshi, T, Takeshita, F, Horii, T, Akira, S (2011) Novel strategies to improve DNA vaccine immunogenicity. Curr Gene Ther 11: pp. 479-84 CrossRef
  11. Prompetchara, E, Ketloy, C, Keelapang, P, Sittisombut, N, Ruxrungtham, K (2014) Induction of Neutralizing Antibody Response against Four Dengue Viruses in Mice by Intramuscular Electroporation of Tetravalent DNA Vaccines. PLoS ONE 9: pp. e92643 CrossRef
  12. Dutton, JL, Li, B, Woo, WP, Marshak, JO, Xu, Y, Huang, ML (2013) A novel DNA vaccine technology conveying protection against a lethal herpes simplex viral challenge in mice. PLoS ONE 8: pp. e76407 CrossRef
  13. Obeng-Adjei, N, Hutnick, NA, Yan, J, Chu, JS, Myles, DJ, Morrow, MP (2013) DNA vaccine cocktail expressing genotype A and C HBV surface and consensus core antigens generates robust cytotoxic and antibody responses in mice and Rhesus macaques. Cancer Gene Ther 20: pp. 652-62 CrossRef
  14. Olgasi, C, Dentelli, P, Rosso, A, Iavello, A, Togliatto, G, Toto, V (2014) DNA vaccination against membrane-bound Kit ligand: a new approach to inhibiting tumour growth and angiogenesis. Eur J Cancer 50: pp. 234-46 CrossRef
  15. Liu, H, Geng, S, Feng, C, Xie, X, Wu, B, Chen, X (2013) A DNA vaccine targeting p42.3 induces protective antitumor immunity via eliciting cytotoxic CD8+T lymphocytes in a murine melanoma model. Hum Vaccin Immunother 9: pp. 2196-202 CrossRef
  16. Ho, PP, Fontoura, P, Ruiz, PJ, Steinman, L, Garren, H (2003) An immunomodulatory GpG oligonucleotide for the treatment of autoimmunity via the innate and adaptive immune systems. J Immunol 171: pp. 4920-6 CrossRef
  17. Wang, Y, Wang, YM, Wang, Y, Zheng, G, Zhang, GY, Zhou, JJ (2013) DNA vaccine encoding CD40 targeted to dendritic cells in situ prevents the development of Heymann nephritis in rats. Kidney Int 83: pp. 223-32 CrossRef
  18. J茅gou, JF, Chan, P, Schouft, MT, Gasque, P, Vaudry, H, Fontaine, M (2007) Protective DNA vaccination against myelin oligodendrocyte glycoprotein is overcome by C3d in experimental autoimmune encephalomyelitis. Mol Immunol 44: pp. 3691-701 CrossRef
  19. Weiss, R, Scheiblhofer, S, Thalhamer, J (2014) Allergens are not pathogens: Why immunization against allergy differs from vaccination against infectious diseases. Hum Vaccin Immunother 10: pp. 703-7 CrossRef
  20. Song, LQ, Li, Y, Li, WN, Zhang, W, Qi, HW, Wu, CG (2013) Safety and immunogenicity of a DNA vaccine encoding human calcium-activated chloride channel 1 (hCLCA1) in asthmatic mice. Int Arch Allergy Immunol 161: pp. 243-51 CrossRef
  21. Pulsawat, P, Pitakpolrat, P, Prompetchara, E, Kaewamatawong, T, Techakriengkrai, N, Sirivichayakul, S (2013) Optimization of a Der p 2-based prophylactic DNA vaccine against house dust mite allergy. Immunol Lett 151: pp. 23-30 CrossRef
  22. Wolff, JA, Malone, RW, Williams, P, Chong, W, Acsadi, G, Jani, A (1990) Direct gene transfer into mouse muscle in vivo. Science 247: pp. 1465-8 CrossRef
  23. Lew, D, Parker, SE, Latimer, T, Abai, AM, Kuwahara-Rundell, A, Doh, SG (1995) Cancer gene therapy using plasmid DNA: pharmacokinetic study of DNA following injection in mice. Hum Gene Ther 6: pp. 553-64 CrossRef
  24. Waine, GJ, McManus, DP (1995) Nucleic acids: vaccines of the future. Parasitol Today 11: pp. 113-6 CrossRef
  25. Mairhofer, J, Lara, AR (2014) Advances in host and vector development for the production of plasmid DNA vaccines. Methods Mol Biol 1139: pp. 505-41 CrossRef
  26. Hassan, IA, Wang, S, Xu, L, Yan, R, Song, X, Li, X (2014) DNA vaccination with a gene encoding Toxoplasma gondii Deoxyribose Phosphate Aldolase (TgDPA) induces partial protective immunity against lethal challenge in mice. Parasit Vectors 7: pp. 431 CrossRef
  27. Cong, H, Zhang, M, Xin, Q, Wang, Z, Li, Y, Zhao, Q (2013) Compound DNA vaccine encoding SAG1/ SAG3 with A2/B subunit of cholera toxin as a geneticadjuvant protects BALB/c mice against Toxoplasma gondii. Parasit Vectors 6: pp. 63 CrossRef
  28. Wang, X, Zhang, L, Chi, Y, Hoellwarth, J, Zhou, S, Wen, X (2010) The nature and combination of subunits used in epitope-based Schistosoma japonicum vaccine formulations affect their efficacy. Parasit Vectors 3: pp. 109 CrossRef
  29. Garg, N, Tarleton, R (2002) Genetic immunization elicits antigen-specific protective immune responses and decreases disease severity in Trypanosoma cruzi infection. Infect Immun 70: pp. 5547-55 CrossRef
  30. Boscardin, SB, Kinoshita, SS, Fujimura, AE, Rodrigues, MM (2003) Immunization with cDNA expressed by amastigotes of Trypanosoma cruzi elicits protective immune response against experimental infection. Infect Immun 71: pp. 2744-57 CrossRef
  31. Miyahira, Y, Katae, M, Takeda, K, Yagita, H, Okumura, K, Kobayashi, S (2003) Activation of natural killer T cells by alpha-galactosylceramide impairs DNA vaccine-induced protective immunity against Trypanosoma cruzi. Infect Immun 71: pp. 1234-41 CrossRef
  32. Mussalem, JS, Vasconcelos, JR, Squaiella, CC, Ananias, RZ, Braga, EG, Rodrigues, MM (2006) Adjuvant effect of the Propionibacterium acnes and its purified soluble polysaccharide on the immunization with plasmidial DNA containing a Trypanosoma cruzi gene. Microbiol Immunol 50: pp. 253-63 CrossRef
  33. Bhatia, V, Garg, NJ (2008) Previously Unrecognized Vaccine Candidates Control Trypanosoma cruzi Infection and Immunopathology in Mice. Clin Vaccine Immunol 15: pp. 1158-64 CrossRef
  34. Dumonteil, E, Bottazzi, ME, Zhan, B, Heffernan, MJ, Jones, K, Valenzuela, JG (2012) Accelerating the development of a therapeutic vaccine for human Chagas disease: rationale and prospects. Expert Rev Vaccines 11: pp. 1043-55 CrossRef
  35. Salgado-Jim茅nez, B, Arce-Fonseca, M, Bayl贸n-Pacheco, L, Talam谩s-Rohana, P, Rosales-Encina, JL (2013) Differential immune response in mice immunized with the A, R or C domain from TcSP protein of Trypanosoma cruzi or with the coding DNAs. Parasite Immunol 35: pp. 32-41 CrossRef
  36. Arce-Fonseca, M, Ramos-Ligonio, A, L贸pez-Monte贸n, A, Salgado-Jim茅nez, B, Talam谩s-Rohana, P, Rosales-Encina, JL (2011) A DNA vaccine encoding for TcSSP4 induces protection against acute and chronic infection in experimental Chagas disease. Int J Biol Sci 7: pp. 1230-8 CrossRef
  37. Arce-Fonseca, M, Ballinas-Verdugo, MA, Zenteno, ER, Su谩rez-Flores, D, Carrillo-S谩nchez, SC, Alejandre-Aguilar, R (2013) Specific humoral and cellular immunity induced by Trypanosoma cruzi DNA immunization in a canine model. Vet Res 44: pp. 15 CrossRef
  38. Rodr铆guez-Morales, O, P茅rez-Leyva, MM, Ballinas-Verdugo, MA, Carrillo-S谩nchez, SC, Rosales-Encina, JL, Alejandre-Aguilar, R (2012) Plasmid DNA immunization with Trypanosoma cruzi genes induces cardiac and clinical protection against Chagas disease in the canine model. Vet Res 43: pp. 79 CrossRef
  39. Rodr铆guez-Morales, O, Carrillo-S谩nchez, SC, Garc铆a-Mendoza, H, Aranda-Fraustro, A, Ballinas-Verdugo, MA, Alejandre-Aguilar, R (2013) Effect of the plasmid-DNA vaccination on macroscopic and microscopic damage caused by the experimental chronic Trypanosoma cruzi infection in the canine model. Biomed Res Int 2013: pp. 826570 CrossRef
  40. Schnapp, AR, Eickhoff, CS, Scharfstein, J, Hoft, DF (2002) Induction of B- and T-cell respondes to cruzipain in the murine model of Trypanosoma cruzi infection. Microbes Infect 4: pp. 805-13 CrossRef
  41. Cazorla, SI, Becker, PD, Frank, FM, Ebensen, T, Sartori, MJ, Corral, RS (2008) Oral vaccination with Salmonella enterica as a cruzipain-DNA delivery system confers protective immunity against Trypanosoma cruzi. Infect Immun 76: pp. 324-33 CrossRef
  42. Fralish, BH, Tarleton, RL (2003) Genetic immunization with LYT1 or a pool of trans-sialidase genes protects mice from lethal Trypanosoma cruzi infection. Vaccine 21: pp. 3070-80 CrossRef
  43. Miyahira, T, Takashima, Y, Kobayashi, S, Matsumoto, Y, Takeuchi, T, Ohyanagi-Hara, M (2005) Immune response against a single CD8+ -T cell epitope induced by virus vector vaccination can successfully control Trypanosoma cruzi infection. Infect Immun 73: pp. 7356-65 CrossRef
  44. Garc铆a, GA, Arnaiz, MR, Laucella, SA, Esteva, MI, Ainciart, N, Riarte, A (2006) Immunological and pathological responses in BALB/c mice induced by genetic administration of Tc 13 antigen of Trypanosoma cruzi. Parasitology 132: pp. 855-66 CrossRef
  45. Morell, M, Thomas, MC, Caballero, T, Alonso, C, L贸pez, MC (2006) The genetic immunization with paraflagellar rod protein-2 fused to the HSP70 confers protection against late Trypanosoma cruzi infection. Vaccine 24: pp. 7046-55 CrossRef
  46. Roffe, E, Souza, AL, Caetano, BC, Machado, PP, Barcelos, LS, Russo, RC (2006) A DNA vaccine encoding CCL4/MIP-1beta enhances myocarditis in experimental Trypanosoma cruzi infection in rats. Microbes Infect 8: pp. 2745-55 CrossRef
  47. Sanchez-Burgos, G, Mezquita-Vega, RG, Escobedo-Ortegon, J, Ramirez-Sierra, MJ, Arjona-Torres, A, Ouaissi, A (2007) Comparative evalutation of therapeutic DNA vaccines against Trypanosoma cruzi in mice. FEMS Immunol Med Microbiol 50: pp. 333-41 CrossRef
  48. Dumonteil, E, Escobedo-Ortegon, J, Reyes-Rodriguez, N, Arjona-Torres, A, Ramirez-Sierra, MJ (2004) Immunotherapy of Trypanosoma cruzi infection with DNA vaccines in mice. Infect Immun 72: pp. 46-53 CrossRef
  49. Zapata-Estrella, H, Hummel-Newell, C, Sanchez-Burgos, G, Escobedo-Ortegon, J, Ramirez-Sierra, MJ, Arjona-Torres, A (2006) Control of Trypanosoma cruzi infection and changes in T-cell populations induced by a therapeutic DNA vaccine in mice. Immunol Lett 103: pp. 186-91 CrossRef
  50. Aparicio-Burgos, JE, Ochoa-Garc铆a, L, Zepeda-Escobar, JA, Gupta, S, Dhiman, M, Mart铆nez, JS (2011) Testing the efficacy of a multi-component DNA-prime/DNA-boost vaccine against Trypanosoma cruzi infection in dogs. PLoS Negl Trop Dis 5: pp. e1050 CrossRef
  51. Rigato, PO, Alencar, BC, Vasconcelos, JR, Dominguez, MR, Ara煤jo, AF, Machado, AV (2011) Heterologous plasmid DNA prime-recombinant human adenovirus 5 boost vaccination generates a stable pool of protective long-lived CD8(+) T effector memory cells specific for a human parasite, Trypanosoma cruzi. Infect Immun 79: pp. 2120-30 CrossRef
  52. Vasconcelos, JR, Bru帽a-Romero, O, Ara煤jo, AF, Dominguez, MR, Ersching, J, Alencar, BC (2012) Pathogen-induced proapoptotic phenotype and high CD95 (Fas) expression accompany a suboptimal CD8+ T-cell response: reversal by adenoviral vaccine. PLoS Pathog 8: pp. e1002699 CrossRef
  53. Eickhoff, CS, Vasconcelos, JR, Sullivan, NL, Blazevic, A, Bruna-Romero, O, Rodrigues, MM (2011) Co-administration of a plasmid DNA encoding IL-15 improves long-term protection of a genetic vaccine against Trypanosoma cruzi. PLoS Negl Trop Dis 5: pp. e983 CrossRef
  54. Nogueira, RT, Nogueira, AR, Pereira, MC, Rodrigues, MM, Neves, PC, Galler, R (2013) Recombinant yellow fever viruses elicit CD8+ T cell responses and protective immunity against Trypanosoma cruzi. PLoS ONE 8: pp. e59347 CrossRef
  
• 刊物主题：Parasitology; Infectious Diseases; Tropical Medicine; Entomology;
• 出版者：BioMed Central
• ISSN：1756-3305

文摘

Chagas disease is a zoonosis caused by Trypanosoma cruzi in which the most affected organ is the heart. Conventional chemotherapy has a very low effectiveness; despite recent efforts, there is currently no better or more effective treatment available. DNA vaccines provide a new alternative for both prevention and treatment of a variety of infectious disorders, including Chagas disease. Recombinant DNA technology has allowed some vaccines to be developed using recombinant proteins or virus-like particles capable of inducing both a humoral and cellular specific immune response. This type of immunization has been successfully used in preclinical studies and there are diverse models for viral, bacterial and/or parasitic diseases, allergies, tumors and other diseases. Therefore, several research groups have been given the task of designing a DNA vaccine against experimental infection with T. cruzi. In this review we explain what DNA vaccines are and the most recent studies that have been done to develop them with prophylactic or therapeutic purposes against Chagas disease.