Molecular basis of embryonic stem cell self-renewal: from signaling pathways to pluripotency network

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• 作者：Guanyi Huang (1) (2)
  Shoudong Ye (1) (2)
  Xingliang Zhou (2)
  Dahai Liu (1)
  Qi-Long Ying (2)
  
  1. Center for Stem Cell and Translational Medicine ; School of Life Sciences ; Anhui University ; Hefei ; 230601 ; PR China
  2. Eli and Edythe Broad Center for Regenerative Medicine and Stem Cell Research at USC ; Department of Stem Cell Biology and Regenerative Medicine ; Keck School of Medicine ; University of Southern California ; Los Angeles ; CA ; 90033 ; USA
  
• 关键词：Embryonic stem cells ; Stem cell self ; renewal ; Pluripotency ; LIF/Stat3 signaling pathway ; Wnt/尾 ; catenin signaling pathway
• 刊名：Cellular and Molecular Life Sciences (CMLS)
• 出版年：2015
• 出版时间：May 2015
• 年：2015
• 卷：72
• 期：9
• 页码：1741-1757
• 全文大小：1,944 KB
• 参考文献：1. Smith, AG (2001) Embryo-derived stem cells: of mice and men. Annu Rev Cell Dev Biol 17: pp. 435-462
  2. Evans, MJ, Kaufman, MH (1981) Establishment in culture of pluripotential cells from mouse embryos. Nature 292: pp. 154-156
  3. Martin, GR (1981) Isolation of a pluripotent cell line from early mouse embryos cultured in medium conditioned by teratocarcinoma stem cells. Proc Natl Acad Sci USA 78: pp. 7634-7638
  4. Thomson, JA, Itskovitz-Eldor, J, Shapiro, SS, Waknitz, MA, Swiergiel, JJ, Marshall, VS (1998) Embryonic stem cell lines derived from human blastocysts. Science 282: pp. 1145-1147
  5. Buehr, M, Meek, S, Blair, K, Yang, J, Ure, J, Silva, J (2008) Capture of authentic embryonic stem cells from rat blastocysts. Cell 135: pp. 1287-1298
  6. Li, P, Tong, C, Mehrian-Shai, R, Jia, L, Wu, N, Yan, Y (2008) Germline competent embryonic stem cells derived from rat blastocysts. Cell 135: pp. 1299-1310
  7. Saiz, N, Plusa, B (2013) Early cell fate decisions in the mouse embryo. Reproduction 145: pp. R65-R80
  8. Nichols, J, Smith, A (2012) Pluripotency in the embryo and in culture. Cold Spring Harb Perspect Biol 4: pp. a008128
  9. Rossant, J (2009) Tam PP. Blastocyst lineage formation, early embryonic asymmetries and axis patterning in the mouse. Development 136: pp. 701-713
  10. Brons IG, Smithers LE, Trotter MW, Rugg-Gunn P, Sun B, Chuva de Sousa Lopes SM et al (2007) Derivation of pluripotent epiblast stem cells from mammalian embryos. Nature 448:191鈥?95
  11. Tesar, PJ, Chenoweth, JG, Brook, FA, Davies, TJ, Evans, EP, Mack, DL (2007) New cell lines from mouse epiblast share defining features with human embryonic stem cells. Nature 448: pp. 196-199
  12. Nichols, J, Smith, A (2009) Naive and primed pluripotent states. Cell Stem Cell 4: pp. 487-492
  13. Hanna, J, Cheng, AW, Saha, K, Kim, J, Lengner, CJ, Soldner, F (2010) Human embryonic stem cells with biological and epigenetic characteristics similar to those of mouse ESCs. Proc Natl Acad Sci USA 107: pp. 9222-9227
  14. Ying, QL, Wray, J, Nichols, J, Batlle-Morera, L, Doble, B, Woodgett, J (2008) The ground state of embryonic stem cell self-renewal. Nature 453: pp. 519-523
  15. Kim, H, Wu, J, Ye, S, Tai, CI, Zhou, X, Yan, H (2013) Modulation of beta-catenin function maintains mouse epiblast stem cell and human embryonic stem cell self-renewal. Nat Commun 4: pp. 2403
  16. Martello, G, Sugimoto, T, Diamanti, E, Joshi, A, Hannah, R, Ohtsuka, S (2012) Esrrb is a pivotal target of the Gsk3/Tcf3 axis regulating embryonic stem cell self-renewal. Cell Stem Cell 11: pp. 491-504
  17. Ying, QL, Nichols, J, Chambers, I, Smith, A (2003) BMP induction of Id proteins suppresses differentiation and sustains embryonic stem cell self-renewal in collaboration with STAT3. Cell 115: pp. 281-292
  18. Smith, AG, Heath, JK, Donaldson, DD, Wong, GG, Moreau, J, Stahl, M (1988) Inhibition of pluripotential embryonic stem cell differentiation by purified polypeptides. Nature 336: pp. 688-690
  19. Williams, RL, Hilton, DJ, Pease, S, Willson, TA, Stewart, CL, Gearing, DP (1988) Myeloid leukaemia inhibitory factor maintains the developmental potential of embryonic stem cells. Nature 336: pp. 684-687
  20. Boyer, LA, Lee, TI, Cole, MF, Johnstone, SE, Levine, SS, Zucker, JP (2005) Core transcriptional regulatory circuitry in human embryonic stem cells. Cell 122: pp. 947-956
  21. Kehler, J, Tolkunova, E, Koschorz, B, Pesce, M, Gentile, L, Boiani, M (2004) Oct4 is required for primordial germ cell survival. EMBO Rep 5: pp. 1078-1083
  22. Nichols, J, Zevnik, B, Anastassiadis, K, Niwa, H, Klewe-Nebenius, D, Chambers, I (1998) Formation of pluripotent stem cells in the mammalian embryo depends on the POU transcription factor Oct4. Cell 95: pp. 379-391
  23. Loh, YH, Wu, Q, Chew, JL, Vega, VB, Zhang, W, Chen, X (2006) The Oct4 and Nanog transcription network regulates pluripotency in mouse embryonic stem cells. Nat Genet 38: pp. 431-440
  24. Takahashi, K, Yamanaka, S (2006) Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors. Cell 126: pp. 663-676
  25. Yu, J, Vodyanik, MA, Smuga-Otto, K, Antosiewicz-Bourget, J, Frane, JL, Tian, S (2007) Induced pluripotent stem cell lines derived from human somatic cells. Science 318: pp. 1917-1920
  26. Takahashi, K, Tanabe, K, Ohnuki, M, Narita, M, Ichisaka, T, Tomoda, K (2007) Induction of pluripotent stem cells from adult human fibroblasts by defined factors. Cell 131: pp. 861-872
  27. Hamanaka, S, Yamaguchi, T, Kobayashi, T, Kato-Itoh, M, Yamazaki, S, Sato, H (2011) Generation of germline-competent rat induced pluripotent stem cells. PLoS One 6: pp. e22008
  28. Niwa, H, Miyazaki, J, Smith, AG (2000) Quantitative expression of Oct-3/4 defines differentiation, dedifferentiation or self-renewal of ES cells. Nat Genet 24: pp. 372-376
  29. Karwacki-Neisius, V, Goke, J, Osorno, R, Halbritter, F, Ng, JH, Weisse, AY (2013) Reduced Oct4 expression directs a robust pluripotent state with distinct signaling activity and increased enhancer occupancy by Oct4 and Nanog. Cell Stem Cell 12: pp. 531-545
  30. Avilion, AA, Nicolis, SK, Pevny, LH, Perez, L, Vivian, N, Lovell-Badge, R (2003) Multipotent cell lineages in early mouse development depend on SOX2 function. Genes Dev 17: pp. 126-140
  31. Wood, HB, Episkopou, V (1999) Comparative expression of the mouse Sox1, Sox2 and Sox3 genes from pre-gastrulation to early somite stages. Mech Dev 86: pp. 197-201
  32. Masui, S, Nakatake, Y, Toyooka, Y, Shimosato, D, Yagi, R, Takahashi, K (2007) Pluripotency governed by Sox2 via regulation of Oct3/4 expression in mouse embryonic stem cells. Nat Cell Biol 9: pp. 625-635
  33. Ivanova, N, Dobrin, R, Lu, R, Kotenko, I, Levorse, J, DeCoste, C (2006) Dissecting self-renewal in stem cells with RNA interference. Nature 442: pp. 533-538
  34. Yuan, H, Corbi, N, Basilico, C, Dailey, L (1995) Developmental-specific activity of the FGF-4 enhancer requires the synergistic action of Sox2 and Oct-3. Genes Dev 9: pp. 2635-2645
  35. Kuroda, T, Tada, M, Kubota, H, Kimura, H, Hatano, SY, Suemori, H (2005) Octamer and Sox elements are required for transcriptional cis regulation of Nanog gene expression. Mol Cell Biol 25: pp. 2475-2485
  36. Nakatake, Y, Fukui, N, Iwamatsu, Y, Masui, S, Takahashi, K, Yagi, R (2006) Klf4 cooperates with Oct3/4 and Sox2 to activate the Lefty1 core promoter in embryonic stem cells. Mol Cell Biol 26: pp. 7772-7782
  37. Tomioka, M, Nishimoto, M, Miyagi, S, Katayanagi, T, Fukui, N, Niwa, H (2002) Identification of Sox-2 regulatory region which is under the control of Oct-3/4-Sox-2 complex. Nucleic Acids Res 30: pp. 3202-3213
  38. Okumura-Nakanishi, S, Saito, M, Niwa, H, Ishikawa, F (2005) Oct-3/4 and Sox2 regulate Oct-3/4 gene in embryonic stem cells. J Biol Chem 280: pp. 5307-5317
  39. MacArthur, BD, Sevilla, A, Lenz, M, Muller, FJ, Schuldt, BM, Schuppert, AA (2012) Nanog-dependent feedback loops regulate murine embryonic stem cell heterogeneity. Nat Cell Biol 14: pp. 1139-1147
  40. Kalmar, T, Lim, C, Hayward, P, Munoz-Descalzo, S, Nichols, J, Garcia-Ojalvo, J (2009) Regulated fluctuations in nanog expression mediate cell fate decisions in embryonic stem cells. PLoS Biol 7: pp. e1000149
  41. Chambers, I, Colby, D, Robertson, M, Nichols, J, Lee, S, Tweedie, S (2003) Functional expression cloning of Nanog, a pluripotency sustaining factor in embryonic stem cells. Cell 113: pp. 643-655
  42. Mitsui, K, Tokuzawa, Y, Itoh, H, Segawa, K, Murakami, M, Takahashi, K (2003) The homeoprotein Nanog is required for maintenance of pluripotency in mouse epiblast and ES cells. Cell 113: pp. 631-642
  43. Darr, H, Mayshar, Y, Benvenisty, N (2006) Overexpression of NANOG in human ES cells enables feeder-free growth while inducing primitive ectoderm features. Development 133: pp. 1193-1201
  44. Chambers, I, Silva, J, Colby, D, Nichols, J, Nijmeijer, B, Robertson, M (2007) Nanog safeguards pluripotency and mediates germline development. Nature 450: pp. 1230-1234
  45. Hyslop, L, Stojkovic, M, Armstrong, L, Walter, T, Stojkovic, P, Przyborski, S (2005) Downregulation of NANOG induces differentiation of human embryonic stem cells to extraembryonic lineages. Stem Cells 23: pp. 1035-1043
  46. Festuccia, N, Osorno, R, Halbritter, F, Karwacki-Neisius, V, Navarro, P, Colby, D (2012) Esrrb is a direct Nanog target gene that can substitute for Nanog function in pluripotent cells. Cell Stem Cell 11: pp. 477-490
  47. Carter, AC, Davis-Dusenbery, BN, Koszka, K, Ichida, JK, Eggan, K (2014) Nanog-Independent Reprogramming to iPSCs with Canonical Factors. Stem Cell Rep 2: pp. 119-126
  48. Schwarz, BA, Bar-Nur, O, Silva, JC, Hochedlinger, K (2014) Nanog is dispensable for the generation of induced pluripotent stem cells. Curr Biol 24: pp. 347-350
  49. Wang, J, Rao, S, Chu, J, Shen, X, Levasseur, DN, Theunissen, TW (2006) A protein interaction network for pluripotency of embryonic stem cells. Nature 444: pp. 364-368
  50. Wu, Q, Chen, X, Zhang, J, Loh, YH, Low, TY, Zhang, W (2006) Sall4 interacts with Nanog and co-occupies Nanog genomic sites in embryonic stem cells. J Biol Chem 281: pp. 24090-24094
  51. Chen, X, Xu, H, Yuan, P, Fang, F, Huss, M, Vega, VB (2008) Integration of external signaling pathways with the core transcriptional network in embryonic stem cells. Cell 133: pp. 1106-1117
  52. Tai, CI, Ying, QL (2013) Gbx2, a LIF/Stat3 target, promotes reprogramming to and retention of the pluripotent ground state. J Cell Sci 126: pp. 1093-1098
  53. Aksoy, I, Sakabedoyan, C, Bourillot, PY, Malashicheva, AB, Mancip, J, Knoblauch, K (2007) Self-renewal of murine embryonic stem cells is supported by the serine/threonine kinases Pim-1 and Pim-3. Stem Cells 25: pp. 2996-3004
  54. Hall, J, Guo, G, Wray, J, Eyres, I, Nichols, J, Grotewold, L (2009) Oct4 and LIF/Stat3 additively induce Kruppel factors to sustain embryonic stem cell self-renewal. Cell Stem Cell 5: pp. 597-609
  55. Zalzman, M, Falco, G, Sharova, LV, Nishiyama, A, Thomas, M, Lee, SL (2010) Zscan4 regulates telomere elongation and genomic stability in ES cells. Nature 464: pp. 858-863
  56. Cartwright, P, McLean, C, Sheppard, A, Rivett, D, Jones, K, Dalton, S (2005) LIF/STAT3 controls ES cell self-renewal and pluripotency by a Myc-dependent mechanism. Development 132: pp. 885-896
  57. Kaji, K, Caballero, IM, MacLeod, R, Nichols, J, Wilson, VA, Hendrich, B (2006) The NuRD component Mbd3 is required for pluripotency of embryonic stem cells. Nat Cell Biol 8: pp. 285-292
  58. Niwa, H, Ogawa, K, Shimosato, D, Adachi, K (2009) A parallel circuit of LIF signalling pathways maintains pluripotency of mouse ES cells. Nature 460: pp. 118-122
  59. Wray, J, Kalkan, T, Gomez-Lopez, S, Eckardt, D, Cook, A, Kemler, R (2011) Inhibition of glycogen synthase kinase-3 alleviates Tcf3 repression of the pluripotency network and increases embryonic stem cell resistance to differentiation. Nat Cell Biol 13: pp. 838-845
  60. Acampora, D, Giovannantonio, LG, Simeone, A (2013) Otx2 is an intrinsic determinant of the embryonic stem cell state and is required for transition to a stable epiblast stem cell condition. Development 140: pp. 43-55
  61. Martello, G, Bertone, P, Smith, A (2013) Identification of the missing pluripotency mediator downstream of leukaemia inhibitory factor. EMBO J 32: pp. 2561-2574
  62. Ye, S, Li, P, Tong, C, Ying, QL (2013) Embryonic stem cell self-renewal pathways converge on the transcription factor Tfcp2l1. EMBO J 32: pp. 2548-2560
  63. Niwa, H, Toyooka, Y, Shimosato, D, Strumpf, D, Takahashi, K, Yagi, R (2005) Interaction between Oct3/4 and Cdx2 determines trophectoderm differentiation. Cell 123: pp. 917-929
  64. Grabole, N, Tischler, J, Hackett, JA, Kim, S, Tang, F, Leitch, HG (2013) Prdm14 promotes germline fate and naive pluripotency by repressing FGF signalling and DNA methylation. EMBO Rep 14: pp. 629-637
  65. Fujikura, J, Yamato, E, Yonemura, S, Hosoda, K, Masui, S, Nakao, K (2002) Differentiation of embryonic stem cells is induced by GATA factors. Genes Dev 16: pp. 784-789
  66. Betschinger, J, Nichols, J, Dietmann, S, Corrin, PD, Paddison, PJ, Smith, A (2013) Exit from pluripotency is gated by intracellular redistribution of the bHLH transcription factor Tfe3. Cell 153: pp. 335-347
  67. Tamm, C, Bower, N, Anneren, C (2011) Regulation of mouse embryonic stem cell self-renewal by a Yes-YAP-TEAD2 signaling pathway downstream of LIF. J Cell Sci 124: pp. 1136-1144
  68. Lian, I, Kim, J, Okazawa, H, Zhao, J, Zhao, B, Yu, J (2010) The role of YAP transcription coactivator in regulating stem cell self-renewal and differentiation. Genes Dev 24: pp. 1106-1118
  69. Adachi K, Nikaido I, Ohta H, Ohtsuka S, Ura H, Kadota M et al (2013) Context-dependent wiring of Sox2 regulatory networks for self-renewal of embryonic and trophoblast stem cells. Mol Cel 52:380鈥?92
  70. O鈥橪oghlen, A, Munoz-Cabello, AM, Gaspar-Maia, A, Wu, HA, Banito, A, Kunowska, N (2012) MicroRNA regulation of Cbx7 mediates a switch of Polycomb orthologs during ESC differentiation. Cell Stem Cell 10: pp. 33-46
  71. Niakan, KK, Ji, H, Maehr, R, Vokes, SA, Rodolfa, KT, Sherwood, RI (2010) Sox17 promotes differentiation in mouse embryonic stem cells by directly regulating extraembryonic gene expression and indirectly antagonizing self-renewal. Genes Dev 24: pp. 312-326
  72. Zhang, J, Tam, WL, Tong, GQ, Wu, Q, Chan, HY, Soh, BS (2006) Sall4 modulates embryonic stem cell pluripotency and early embryonic development by the transcriptional regulation of Pou5f1. Nat Cell Biol 8: pp. 1114-1123
  73. Smith, AG, Hooper, ML (1987) Buffalo rat liver cells produce a diffusible activity which inhibits the differentiation of murine embryonal carcinoma and embryonic stem cells. Dev Biol 121: pp. 1-9
  74. Niwa, H, Burdon, T, Chambers, I, Smith, A (1998) Self-renewal of pluripotent embryonic stem cells is mediated via activation of STAT3. Genes Dev 12: pp. 2048-2060
  75. Heinrich, PC, Behrmann, I, Haan, S, Hermanns, HM, Muller-Newen, G, Schaper, F (2003) Principles of interleukin (IL)-6-type cytokine signalling and its regulation. Biochem J 374: pp. 1-20
  76. Wang, X, Crowe, PJ, Goldstein, D, Yang, JL (2012) STAT3 inhibition, a novel approach to enhancing targeted therapy in human cancers (review). Int J Oncol 41: pp. 1181-1191
  77. Sasse, J, Hemmann, U, Schwartz, C, Schniertshauer, U, Heesel, B, Landgraf, C (1997) Mutational analysis of acute-phase response factor/Stat3 activation and dimerization. Mol Cell Biol 17: pp. 4677-4686
  78. Levy, DE, Darnell, JE (2002) Stats: transcriptional control and biological impact. Nat Rev Mol Cell Biol 3: pp. 651-662
  79. Burdon, T, Chambers, I, Stracey, C, Niwa, H, Smith, A (1999) Signaling mechanisms regulating self-renewal and differentiation of pluripotent embryonic stem cells. Cells Tissues Organs 165: pp. 131-143
  80. Hirai, H, Karian, P, Kikyo, N (2011) Regulation of embryonic stem cell self-renewal and pluripotency by leukaemia inhibitory factor. Biochem J 438: pp. 11-23
  81. Migone, TS, Rodig, S, Cacalano, NA, Berg, M, Schreiber, RD, Leonard, WJ (1998) Functional cooperation of the interleukin-2 receptor beta chain and Jak1 in phosphatidylinositol 3-kinase recruitment and phosphorylation. Mol Cell Biol 18: pp. 6416-6422
  82. Paling, NR, Wheadon, H, Bone, HK, Welham, MJ (2004) Regulation of embryonic stem cell self-renewal by phosphoinositide 3-kinase-dependent signaling. J Biol Chem 279: pp. 48063-48070
  83. Fukada, T, Hibi, M, Yamanaka, Y, Takahashi-Tezuka, M, Fujitani, Y, Yamaguchi, T (1996) Two signals are necessary for cell proliferation induced by a cytokine receptor gp130: involvement of STAT3 in anti-apoptosis. Immunity 5: pp. 449-460
  84. Matsuda, T, Nakamura, T, Nakao, K, Arai, T, Katsuki, M, Heike, T (1999) STAT3 activation is sufficient to maintain an undifferentiated state of mouse embryonic stem cells. EMBO J 18: pp. 4261-4269
  85. Burdon, T, Stracey, C, Chambers, I, Nichols, J, Smith, A (1999) Suppression of SHP-2 and ERK signalling promotes self-renewal of mouse embryonic stem cells. Dev Biol 210: pp. 30-43
  86. Huang G, Yan H, Ye S, Tong C, Ying QL (2013) STAT3 phosphorylation at tyrosine 705 and serine 727 differentially regulates mouse ES cell fates. Stem Cells 32:1149鈥?160
  87. Tai, CI, Schulze, EN, Ying, QL (2014) Stat3 signaling regulates embryonic stem cell fate in a dose-dependent manner. Biol Open 3: pp. 958-965
  88. Snyder, M, Huang, XY, Zhang, JJ (2008) Identification of novel direct Stat3 target genes for control of growth and differentiation. J Biol Chem 283: pp. 3791-3798
  89. Sekkai, D, Gruel, G, Herry, M, Moucadel, V, Constantinescu, SN, Albagli, O (2005) Microarray analysis of LIF/Stat3 transcriptional targets in embryonic stem cells. Stem Cells 23: pp. 1634-1642
  90. Bourillot, PY, Aksoy, I, Schreiber, V, Wianny, F, Schulz, H, Hummel, O (2009) Novel STAT3 target genes exert distinct roles in the inhibition of mesoderm and endoderm differentiation in cooperation with Nanog. Stem Cells 27: pp. 1760-1771
  91. Cinelli, P, Casanova, EA, Uhlig, S, Lochmatter, P, Matsuda, T, Yokota, T (2008) Expression profiling in transgenic FVB/N embryonic stem cells overexpressing STAT3. BMC Dev Biol 8: pp. 57
  92. Xie, X, Chan, KS, Cao, F, Huang, M, Li, Z, Lee, A (2009) Imaging of STAT3 signaling pathway during mouse embryonic stem cell differentiation. Stem Cells Dev 18: pp. 205-214
  93. Kidder, BL, Yang, J, Palmer, S (2008) Stat3 and c-Myc genome-wide promoter occupancy in embryonic stem cells. PLoS One 3: pp. e3932
  94. Casanova, EA, Shakhova, O, Patel, SS, Asner, IN, Pelczar, P, Weber, FA (2011) Pramel7 mediates LIF/STAT3-dependent self-renewal in embryonic stem cells. Stem Cells 29: pp. 474-485
  95. Sar, A, Ponjevic, D, Nguyen, M, Box, AH, Demetrick, DJ (2009) Identification and characterization of demethylase JMJD1A as a gene upregulated in the human cellular response to hypoxia. Cell Tissue Res 337: pp. 223-234
  96. Li, Y, McClintick, J, Zhong, L, Edenberg, HJ, Yoder, MC, Chan, RJ (2005) Murine embryonic stem cell differentiation is promoted by SOCS-3 and inhibited by the zinc finger transcription factor Klf4. Blood 105: pp. 635-637
  97. Guo, G, Yang, J, Nichols, J, Hall, JS, Eyres, I, Mansfield, W (2009) Klf4 reverts developmentally programmed restriction of ground state pluripotency. Development 136: pp. 1063-1069
  98. Daheron, L, Opitz, SL, Zaehres, H, Lensch, MW, Andrews, PW, Itskovitz-Eldor, J (2004) LIF/STAT3 signaling fails to maintain self-renewal of human embryonic stem cells. Stem Cells 22: pp. 770-778
  99. Oosten, AL, Costa, Y, Smith, A, Silva, JC (2012) JAK/STAT3 signalling is sufficient and dominant over antagonistic cues for the establishment of naive pluripotency. Nat Commun 3: pp. 817
  100. Yang, J, Oosten, AL, Theunissen, TW, Guo, G, Silva, JC, Smith, A (2010) Stat3 activation is limiting for reprogramming to ground state pluripotency. Cell Stem Cell 7: pp. 319-328
  101. Gafni, O, Weinberger, L, Mansour, AA, Manor, YS, Chomsky, E, Ben-Yosef, D (2013) Derivation of novel human ground state naive pluripotent stem cells. Nature 504: pp. 282-286
  102. Ware CB, Nelson AM, Mecham B, Hesson J, Zhou W, Jonlin EC et al (2014) Derivation of naive human embryonic stem cells. In: Proceedings of the National Academy of Sciences of the United States of America 2014
  103. O鈥橪eary, T, Heindryckx, B, Lierman, S, Bruggen, D, Goeman, JJ, Vandewoestyne, M (2012) Tracking the progression of the human inner cell mass during embryonic stem cell derivation. Nat Biotechnol 30: pp. 278-282
  104. Takashima, Y, Guo, G, Loos, R, Nichols, J, Ficz, G, Krueger, F (2014) Resetting transcription factor control circuitry toward ground-state pluripotency in human. Cell 158: pp. 1254-1269
  105. Renfree, MB, Shaw, G (2000) Diapause. Annu Rev Physiol 62: pp. 353-375
  106. Nichols, J, Chambers, I, Taga, T, Smith, A (2001) Physiological rationale for responsiveness of mouse embryonic stem cells to gp130 cytokines. Development 128: pp. 2333-2339
  107. Brook, FA, Gardner, RL (1997) The origin and efficient derivation of embryonic stem cells in the mouse. Proc Natl Acad Sci USA 94: pp. 5709-5712
  108. Ying, QL, Smith, AG (2003) Defined conditions for neural commitment and differentiation. Methods Enzymol 365: pp. 327-341
  109. Wray, J, Kalkan, T, Smith, AG (2010) The ground state of pluripotency. Biochem Soc Trans 38: pp. 1027-1032
  110. Nichols, J, Jones, K, Phillips, JM, Newland, SA, Roode, M, Mansfield, W (2009) Validated germline-competent embryonic stem cell lines from nonobese diabetic mice. Nat Med 15: pp. 814-818
  111. Ye, S, Tan, L, Yang, R, Fang, B, Qu, S, Schulze, EN (2012) Pleiotropy of glycogen synthase kinase-3 inhibition by CHIR99021 promotes self-renewal of embryonic stem cells from refractory mouse strains. PLoS One 7: pp. e35892
  112. Wetering, M, Cavallo, R, Dooijes, D, Beest, M, Es, J, Loureiro, J (1997) Armadillo coactivates transcription driven by the product of the Drosophila segment polarity gene dTCF. Cell 88: pp. 789-799
  113. Valenta, T, Hausmann, G, Basler, K (2012) The many faces and functions of beta-catenin. EMBO J 31: pp. 2714-2736
  114. Lyashenko, N, Winter, M, Migliorini, D, Biechele, T, Moon, RT, Hartmann, C (2011) Differential requirement for the dual functions of beta-catenin in embryonic stem cell self-renewal and germ layer formation. Nat Cell Biol 13: pp. 753-761
  115. Meek, S, Wei, J, Sutherland, L, Nilges, B, Buehr, M, Tomlinson, SR (2013) Tuning of beta-catenin activity is required to stabilize self-renewal of rat embryonic stem cells. Stem Cells 31: pp. 2104-2115
  116. Atlasi, Y, Noori, R, Gaspar, C, Franken, P, Sacchetti, A, Rafati, H (2013) Wnt signaling regulates the lineage differentiation potential of mouse embryonic stem cells through Tcf3 down-regulation. PLoS Genet 9: pp. e1003424
  117. Shy, BR, Wu, CI, Khramtsova, GF, Zhang, JY, Olopade, OI, Goss, KH (2013) Regulation of Tcf7l1 DNA binding and protein stability as principal mechanisms of Wnt/beta-catenin signaling. Cell Rep 4: pp. 1-9
  118. Hikasa, H, Ezan, J, Itoh, K, Li, X, Klymkowsky, MW, Sokol, SY (2010) Regulation of TCF3 by Wnt-dependent phosphorylation during vertebrate axis specification. Dev Cell 19: pp. 521-532
  119. Cole, MF, Johnstone, SE, Newman, JJ, Kagey, MH, Young, RA (2008) Tcf3 is an integral component of the core regulatory circuitry of embryonic stem cells. Genes Dev 22: pp. 746-755
  120. Yi, F, Pereira, L, Merrill, BJ (2008) Tcf3 functions as a steady-state limiter of transcriptional programs of mouse embryonic stem cell self-renewal. Stem Cells 26: pp. 1951-1960
  121. Yi, F, Pereira, L, Hoffman, JA, Shy, BR, Yuen, CM, Liu, DR (2011) Opposing effects of Tcf3 and Tcf1 control Wnt stimulation of embryonic stem cell self-renewal. Nat Cell Biol 13: pp. 762-770
  122. Pereira, L, Yi, F, Merrill, BJ (2006) Repression of Nanog gene transcription by Tcf3 limits embryonic stem cell self-renewal. Mol Cell Biol 26: pp. 7479-7491
  123. Wagner, RT, Xu, X, Yi, F, Merrill, BJ, Cooney, AJ (2010) Canonical Wnt/beta-catenin regulation of liver receptor homolog-1 mediates pluripotency gene expression. Stem Cells 28: pp. 1794-1804
  124. Tanaka, SS, Kojima, Y, Yamaguchi, YL, Nishinakamura, R (2011) Tam PP. Impact of WNT signaling on tissue lineage differentiation in the early mouse embryo. Dev Growth Differ 53: pp. 843-856
  125. Heng, JC, Feng, B, Han, J, Jiang, J, Kraus, P, Ng, JH (2010) The nuclear receptor Nr5a2 can replace Oct4 in the reprogramming of murine somatic cells to pluripotent cells. Cell Stem Cell 6: pp. 167-174
  126. Guo, G, Smith, A (2010) A genome-wide screen in EpiSCs identifies Nr5a nuclear receptors as potent inducers of ground state pluripotency. Development 137: pp. 3185-3192
  127. Fuhrmann, G, Chung, AC, Jackson, KJ, Hummelke, G, Baniahmad, A, Sutter, J (2001) Mouse germline restriction of Oct4 expression by germ cell nuclear factor. Dev Cell 1: pp. 377-387
  128. Gu, P, LeMenuet, D, Chung, AC, Mancini, M, Wheeler, DA, Cooney, AJ (2005) Orphan nuclear receptor GCNF is required for the repression of pluripotency genes during retinoic acid-induced embryonic stem cell differentiation. Mol Cell Biol 25: pp. 8507-8519
  129. Chen, Y, Blair, K, Smith, A (2013) Robust Self-Renewal of Rat Embryonic Stem Cells Requires Fine-Tuning of Glycogen Synthase Kinase-3 Inhibition. Stem Cell Reports 1: pp. 209-217
  130. Ullmann, U, Gilles, C, Rycke, M, Velde, H, Sermon, K, Liebaers, I (2008) GSK-3-specific inhibitor-supplemented hESC medium prevents the epithelial-mesenchymal transition process and the up-regulation of matrix metalloproteinases in hESCs cultured in feeder-free conditions. Mol Hum Reprod 14: pp. 169-179
  131. Sato, N, Meijer, L, Skaltsounis, L, Greengard, P, Brivanlou, AH (2004) Maintenance of pluripotency in human and mouse embryonic stem cells through activation of Wnt signaling by a pharmacological GSK-3-specific inhibitor. Nat Med 10: pp. 55-63
  132. Cai, L, Ye, Z, Zhou, BY, Mali, P, Zhou, C, Cheng, L (2007) Promoting human embryonic stem cell renewal or differentiation by modulating Wnt signal and culture conditions. Cell Res 17: pp. 62-72
  133. Dravid, G, Ye, Z, Hammond, H, Chen, G, Pyle, A, Donovan, P (2005) Defining the role of Wnt/beta-catenin signaling in the survival, proliferation, and self-renewal of human embryonic stem cells. Stem Cells 23: pp. 1489-1501
  134. Nakanishi, M, Kurisaki, A, Hayashi, Y, Warashina, M, Ishiura, S, Kusuda-Furue, M (2009) Directed induction of anterior and posterior primitive streak by Wnt from embryonic stem cells cultured in a chemically defined serum-free medium. FASEB J 23: pp. 114-122
  135. Davidson, KC, Adams, AM, Goodson, JM, McDonald, CE, Potter, JC, Berndt, JD (2012) Wnt/beta-catenin signaling promotes differentiation, not self-renewal, of human embryonic stem cells and is repressed by Oct4. Proc Natl Acad Sci USA 109: pp. 4485-4490
  136. Sumi, T, Tsuneyoshi, N, Nakatsuji, N, Suemori, H (2008) Defining early lineage specification of human embryonic stem cells by the orchestrated balance of canonical Wnt/beta-catenin. Activin/Nodal and BMP signaling. Development 135: pp. 2969-2979
  137. Berge, D, Kurek, D, Blauwkamp, T, Koole, W, Maas, A, Eroglu, E (2011) Embryonic stem cells require Wnt proteins to prevent differentiation to epiblast stem cells. Nat Cell Biol 13: pp. 1070-1075
  138. Rappolee, DA, Basilico, C, Patel, Y, Werb, Z (1994) Expression and function of FGF-4 in peri-implantation development in mouse embryos. Development 120: pp. 2259-2269
  139. Niswander, L, Martin, GR (1992) Fgf-4 expression during gastrulation, myogenesis, limb and tooth development in the mouse. Development 114: pp. 755-768
  140. Feldman, B, Poueymirou, W, Papaioannou, VE, DeChiara, TM, Goldfarb, M (1995) Requirement of FGF-4 for postimplantation mouse development. Science 267: pp. 246-249
  141. Tanaka, S, Kunath, T, Hadjantonakis, AK, Nagy, A, Rossant, J (1998) Promotion of trophoblast stem cell proliferation by FGF4. Science 282: pp. 2072-2075
  142. Kunath, T, Arnaud, D, Uy, GD, Okamoto, I, Chureau, C, Yamanaka, Y (2005) Imprinted X-inactivation in extra-embryonic endoderm cell lines from mouse blastocysts. Development 132: pp. 1649-1661
  143. Yoshida-Koide, U, Matsuda, T, Saikawa, K, Nakanuma, Y, Yokota, T, Asashima, M (2004) Involvement of Ras in extraembryonic endoderm differentiation of embryonic stem cells. Biochem Biophys Res Commun 313: pp. 475-481
  144. Cheng, AM, Saxton, TM, Sakai, R, Kulkarni, S, Mbamalu, G, Vogel, W (1998) Mammalian Grb2 regulates multiple steps in embryonic development and malignant transformation. Cell 95: pp. 793-803
  145. Lanner, F, Rossant, J (2010) The role of FGF/Erk signaling in pluripotent cells. Development 137: pp. 3351-3360
  146. Coutu, DL, Galipeau, J (2011) Roles of FGF signaling in stem cell self-renewal, senescence and aging. Aging 3: pp. 920-933
  147. Wilder, PJ, Kelly, D, Brigman, K, Peterson, CL, Nowling, T, Gao, QS (1997) Inactivation of the FGF-4 gene in embryonic stem cells alters the growth and/or the survival of their early differentiated progeny. Dev Biol 192: pp. 614-629
  148. Kunath, T, Saba-El-Leil, MK, Almousailleakh, M, Wray, J, Meloche, S, Smith, A (2007) FGF stimulation of the Erk1/2 signalling cascade triggers transition of pluripotent embryonic stem cells from self-renewal to lineage commitment. Development 134: pp. 2895-2902
  149. Batlle-Morera, L, Smith, A, Nichols, J (2008) Parameters influencing derivation of embryonic stem cells from murine embryos. Genesis 46: pp. 758-767
  150. Yang, SH, Kalkan, T, Morrisroe, C, Smith, A, Sharrocks, AD (2012) A genome-wide RNAi screen reveals MAP kinase phosphatases as key ERK pathway regulators during embryonic stem cell differentiation. PLoS Genet 8: pp. e1003112
  151. Nichols, J, Silva, J, Roode, M, Smith, A (2009) Suppression of Erk signalling promotes ground state pluripotency in the mouse embryo. Development 136: pp. 3215-3222
  152. Silva, J, Nichols, J, Theunissen, TW, Guo, G, Oosten, AL, Barrandon, O (2009) Nanog is the gateway to the pluripotent ground state. Cell 138: pp. 722-737
  153. Kim, MO, Kim, SH, Cho, YY, Nadas, J, Jeong, CH, Yao, K (2012) ERK1 and ERK2 regulate embryonic stem cell self-renewal through phosphorylation of Klf4. Nat Struct Mol Biol 19: pp. 283-290
  154. Vallier, L, Alexander, M, Pedersen, RA (2005) Activin/Nodal and FGF pathways cooperate to maintain pluripotency of human embryonic stem cells. J Cell Sci 118: pp. 4495-4509
  155. Greber, B, Lehrach, H, Adjaye, J (2007) Fibroblast growth factor 2 modulates transforming growth factor beta signaling in mouse embryonic fibroblasts and human ESCs (hESCs) to support hESC self-renewal. Stem Cells 25: pp. 455-464
  156. Greber, B, Wu, G, Bernemann, C, Joo, JY, Han, DW, Ko, K (2010) Conserved and divergent roles of FGF signaling in mouse epiblast stem cells and human embryonic stem cells. Cell Stem Cell 6: pp. 215-226
  157. Li, J, Wang, G, Wang, C, Zhao, Y, Zhang, H, Tan, Z (2007) MEK/ERK signaling contributes to the maintenance of human embryonic stem cell self-renewal. Differentiation 75: pp. 299-307
  158. Bendall, SC, Stewart, MH, Menendez, P, George, D, Vijayaragavan, K, Werbowetski-Ogilvie, T (2007) IGF and FGF cooperatively establish the regulatory stem cell niche of pluripotent human cells in vitro. Nature 448: pp. 1015-1021
  159. Singh, AM, Reynolds, D, Cliff, T, Ohtsuka, S, Mattheyses, AL, Sun, Y (2012) Signaling network crosstalk in human pluripotent cells: a Smad2/3-regulated switch that controls the balance between self-renewal and differentiation. Cell Stem Cell 10: pp. 312-326
  160. Shi, Y, Massague, J (2003) Mechanisms of TGF-beta signaling from cell membrane to the nucleus. Cell 113: pp. 685-700
  161. Wilson, PA, Hemmati-Brivanlou, A (1995) Induction of epidermis and inhibition of neural fate by Bmp-4. Nature 376: pp. 331-333
  162. Fei, T, Xia, K, Li, Z, Zhou, B, Zhu, S, Chen, H (2010) Genome-wide mapping of SMAD target genes reveals the role of BMP signaling in embryonic stem cell fate determination. Genome Res 20: pp. 36-44
  163. Qi, X, Li, TG, Hao, J, Hu, J, Wang, J, Simmons, H (2004) BMP4 supports self-renewal of embryonic stem cells by inhibiting mitogen-activated protein kinase pathways. Proc Natl Acad Sci USA 101: pp. 6027-6032
  164. Li, Z, Fei, T, Zhang, J, Zhu, G, Wang, L, Lu, D (2012) BMP4 Signaling Acts via dual-specificity phosphatase 9 to control ERK activity in mouse embryonic stem cells. Cell Stem Cell 10: pp. 171-182
  165. Zhang, P, Li, J, Tan, Z, Wang, C, Liu, T, Chen, L (2008) Short-term BMP-4 treatment initiates mesoderm induction in human embryonic stem cells. Blood 111: pp. 1933-1941
  166. Xu, RH, Chen, X, Li, DS, Li, R, Addicks, GC, Glennon, C (2002) BMP4 initiates human embryonic stem cell differentiation to trophoblast. Nat Biotechnol 20: pp. 1261-1264
  167. Xu, RH, Peck, RM, Li, DS, Feng, X, Ludwig, T, Thomson, JA (2005) Basic FGF and suppression of BMP signaling sustain undifferentiated proliferation of human ES cells. Nat Methods 2: pp. 185-190
  168. Vallier, L, Mendjan, S, Brown, S, Chng, Z, Teo, A, Smithers, LE (2009) Activin/Nodal signalling maintains pluripotency by controlling Nanog expression. Development 136: pp. 1339-1349
  169. Xiao, L, Yuan, X, Sharkis, SJ (2006) Activin A maintains self-renewal and regulates fibroblast growth factor, Wnt, and bone morphogenic protein pathways in human embryonic stem cells. Stem Cells 24: pp. 1476-1486
  170. Xu, RH, Sampsell-Barron, TL, Gu, F, Root, S, Peck, RM, Pan, G (2008) NANOG is a direct target of TGFbeta/activin-mediated SMAD signaling in human ESCs. Cell Stem Cell 3: pp. 196-206
  171. Brown, S, Teo, A, Pauklin, S, Hannan, N, Cho, CH, Lim, B (2011) Activin/Nodal signaling controls divergent transcriptional networks in human embryonic stem cells and in endoderm progenitors. Stem Cells 29: pp. 1176-1185
  172. Mullen, AC, Orlando, DA, Newman, JJ, Loven, J, Kumar, RM, Bilodeau, S (2011) Master transcription factors determine cell-type-specific responses to TGF-beta signaling. Cell 147: pp. 565-576
  173. Breitkreutz, D, Braiman-Wiksman, L, Daum, N, Denning, MF, Tennenbaum, T (2007) Protein kinase C family: on the crossroads of cell signaling in skin and tumor epithelium. J Cancer Res Clin Oncol 133: pp. 793-808
  174. Heo, JS, Han, HJ (2006) ATP stimulates mouse embryonic stem cell proliferation via protein kinase C, phosphatidylinositol 3-kinase/Akt, and mitogen-activated protein kinase signaling pathways. Stem Cells 24: pp. 2637-2648
  175. Quinlan, LR, Faherty, S, Kane, MT (2003) Phospholipase C and protein kinase C involvement in mouse embryonic stem-cell proliferation and apoptosis. Reproduction 126: pp. 121-131
  176. Garavello, NM, Pena, DA, Bonatto, JM, Duarte, ML, Costa-Junior, HM, Schumacher, RI (2013) Activation of protein kinase C delta by psideltaRACK peptide promotes embryonic stem cell proliferation through ERK 1/2. J Proteomics 94: pp. 497-512
  177. Dutta, D, Ray, S, Home, P, Larson, M, Wolfe, MW, Paul, S (2011) Self-renewal versus lineage commitment of embryonic stem cells: protein kinase C signaling shifts the balance. Stem Cells 29: pp. 618-628
  178. Rajendran, G, Dutta, D, Hong, J, Paul, A, Saha, B, Mahato, B (2013) Inhibition of protein kinase C signaling maintains rat embryonic stem cell pluripotency. J Biol Chem 288: pp. 24351-24362
  179. Feng, X, Zhang, J, Smuga-Otto, K, Tian, S, Yu, J, Stewart, R (2012) Protein kinase C mediated extraembryonic endoderm differentiation of human embryonic stem cells. Stem Cells 30: pp. 461-470
  180. Kinehara, M, Kawamura, S, Tateyama, D, Suga, M, Matsumura, H, Mimura, S (2013) Protein kinase C regulates human pluripotent stem cell self-renewal. PLoS One 8: pp. e54122
  181. Theunissen, TW, Powell, BE, Wang, H, Mitalipova, M, Faddah, DA, Reddy, J (2014) Systematic identification of culture conditions for induction and maintenance of naive human pluripotency. Cell Stem Cell 15: pp. 471-487
  182. Surface, LE, Thornton, SR, Boyer, LA (2010) Polycomb group proteins set the stage for early lineage commitment. Cell Stem Cell 7: pp. 288-298
  183. Marson, A, Levine, SS, Cole, MF, Frampton, GM, Brambrink, T, Johnstone, S (2008) Connecting microRNA genes to the core transcriptional regulatory circuitry of embryonic stem cells. Cell 134: pp. 521-533
  
• 刊物类别：Biomedical and Life Sciences
• 刊物主题：Life Sciences
  Cell Biology
  Biomedicine
  Life Sciences
  Biochemistry
  
• 出版者：Birkh盲user Basel
• ISSN：1420-9071

文摘

Embryonic stem cells (ESCs) can be maintained in culture indefinitely while retaining the capacity to generate any type of cell in the body, and therefore not only hold great promise for tissue repair and regeneration, but also provide a powerful tool for modeling human disease and understanding biological development. In order to fulfill the full potential of ESCs, it is critical to understand how ESC fate, whether to self-renew or to differentiate into specialized cells, is regulated. On the molecular level, ESC fate is controlled by the intracellular transcriptional regulatory networks that respond to various extrinsic signaling stimuli. In this review, we discuss and compare important signaling pathways in the self-renewal and differentiation of mouse, rat, and human ESCs with an emphasis on how these pathways integrate into ESC-specific transcription circuitries. This will be beneficial for understanding the common and conserved mechanisms that govern self-renewal, and for developing novel culture conditions that support ESC derivation and maintenance.