The role of P-cadherin in skin biology and skin pathology: lessons from the hair follicle

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• 作者：Liat Samuelov ; Eli Sprecher ; Ralf Paus
• 关键词：P ; cadherin ; HJMD syndrome ; EEM syndrome ; Wnt signaling ; 尾 ; Catenin
• 刊名：Cell and Tissue Research
• 出版年：2015
• 出版时间：June 2015
• 年：2015
• 卷：360
• 期：3
• 页码：761-771
• 全文大小：875 KB
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• 作者单位：Liat Samuelov (1)
  Eli Sprecher (1) (2)
  Ralf Paus (3) (4)
  
  1. Department of Dermatology, Tel Aviv Sourasky Medical Center, 6 Weizmann Street, Tel Aviv, 64239, Israel
  2. Department of Human Molecular Genetics & Biochemistry, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel
  3. Dermatology Research Centre, Institute of Inflammation and Repair, University of Manchester, Manchester, UK
  4. Department of Dermatology, University of M眉nster, M眉nster, Germany
  
• 刊物类别：Biomedical and Life Sciences
• 刊物主题：Biomedicine
  Human Genetics
  Proteomics
  Molecular Medicine
  
• 出版者：Springer Berlin / Heidelberg
• ISSN：1432-0878

文摘

Adherens junctions (AJs) are one of the major intercellular junctions in various epithelia including the epidermis and the follicular epithelium. AJs connect the cell surface to the actin cytoskeleton and comprise classic transmembrane cadherins, such as P-cadherin, armadillo family proteins, and actin microfilaments. Loss-of-function mutations in CDH3, which encodes P-cadherin, result in two allelic autosomal recessive disorders: hypotrichosis with juvenile macular dystrophy (HJMD) and ectodermal dysplasia, ectrodactyly, and macular dystrophy (EEM) syndromes. Both syndromes feature sparse hair heralding progressive macular dystrophy. EEM syndrome is characterized in addition by ectodermal and limb defects. Recent studies have demonstrated that, together with its involvement in cell-cell adhesion, P-cadherin plays a crucial role in regulating cell signaling, malignant transformation, and other major intercellular processes. Here, we review the roles of P-cadherin in skin and hair biology, with emphasize on human hair growth, cycling and pigmentation.