Key Fibrogenic Signaling

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• 作者：Weichun He ; Chunsun Dai
• 关键词：Fibrosis ; Smad ; Mitogen ; activated protein kinase ; Phosphoinositide 3 kinase ; Wnt/尾 ; catenin ; Sonic hedgehog
• 刊名：Current Pathobiology Reports
• 出版年：2015
• 出版时间：June 2015
• 年：2015
• 卷：3
• 期：2
• 页码：183-192
• 全文大小：441 KB
• 参考文献：Papers of particular importance, published from 2009 to present, have been highlighted as: 鈥?Of importance 鈥⑩€?Of major importance1.鈥⑩€?Wynn TA, Ramalingam TR (2012) Mechanisms of fibrosis: therapeutic translation for fibrotic disease. Nat Med 18:1028鈥?040. The authors discuss how key components of the innate and adaptive immune response contribute to the pathogenesis of fibrosis
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• 作者单位：Weichun He (1)
  Chunsun Dai (1)
  
  1. Center for Kidney Disease, Second Affiliated Hospital, Nanjing Medical University, 262 North Zhongshan Road, Nanjing, 210003, China
  
• 刊物主题：Pathology;
• 出版者：Springer US
• ISSN：2167-485X

文摘

Fibrosis is defined as an excessive accumulation of extracellular matrix components that lead to the destruction of organ architecture and impairment of organ function. Moreover, fibrosis is an intricate process attributable to a variety of interlaced fibrogenic signals and intrinsic mechanisms of activation of myofibroblasts. Being the dominant matrix-producing cells in organ fibrosis, myofibroblasts may be differentiated from various types of precursor cells. Identification of the signal pathways that play a key role in the pathogenesis of fibrotic diseases may suggest potential therapeutic targets. Here, we emphasize several intracellular signaling pathways that control the activation of myofibroblasts and matrix production.