Anticarcinogenic Effect of Corn Tortilla Against 1,2-Dimethylhydrazine (DMH)-Induced Colon Carcinogenesis in Sprague鈥揇awley Rats

详细信息    查看全文

• 作者：Rosal铆a Reynoso-Camacho ; Guadalupe Guerrero-Villanueva…
• 关键词：Corn tortilla ; Zea mays L ; Anticarcinogenic activity ; Colon cancer
• 刊名：Plant Foods for Human Nutrition
• 出版年：2015
• 出版时间：June 2015
• 年：2015
• 卷：70
• 期：2
• 页码：146-152
• 全文大小：498 KB
• 参考文献：1.Instituto Nacional de Estad铆stica, Geograf铆a e Inform谩tica. INEGI. 2012. www.鈥媔negi.鈥媑ob.鈥媘x
  2.Ricciardiello L, Bazzoli F, Fogliano V (2011) Phytochemicals and colorectal cancer prevention鈥搈yth or reality? Nat Rev Gastroenterol Hepatol 8:592鈥?96View Article
  3.Paredes-L贸pez O, Saharopulos-Paredes ME (1983) A review of tortilla production technology. Bakers Dig 13:16鈥?5
  4.G贸mez-Aldapa C, Mart铆nez-Bustos F, Figueroa-C谩rdenas JD, Ordorica-Falomir CA (1999) A comparison of the quality of whole corn tortillas made from instant corn flours by traditional or extrusion process. Int J Food Sci Technol 34:391鈥?99View Article
  5.Figueroa JDC, Acero GMG, Vasco MNL, Lozano GA, Flores ALM (2003) Nutritional quality of nixtamal tortillas fortified with vitamins and soy proteins. J Food Sci Nutr 54:189鈥?00
  6.Del Pozo-Insfran D, Brenes CH, Serna-Saldivar SO, Talcott ST (2006) Polyphenolic and antioxidant content of white and blue corn (Zea mays L.) products. Food Res Int 39:696鈥?03View Article
  7.De la Parra C, Serna Saldivar SO, Rui Hai L (2007) Effect of processing on the phytochemical profiles and antioxidant activity of corn for production of masa, tortillas, and tortilla chip. J Agric Food Chem 55:4177鈥?183View Article
  8.Mora-Rochin S, Guti茅rrez-Uribe JA, Serna-Saldivar SO, S谩nchez-Pe帽a P, Reyes-Moreno C, Mil谩n-Carrillo J (2010) Phenolic content and antioxidant activity of tortillas produced from pigmented maize processed by conventional nixtamalization or extrusion cooking. J Cereal Sci 52:502鈥?08View Article
  9.V谩zquez-Carrillo G, Garc铆a-Lara S, Salinas-Moreno Y, Bergvinson DJ, Palacios-Rojas N (2011) Grain and tortilla quality in landraces and improved maize grown in the highlands of Mexico. Plant Foods Hum Nutr 66:203鈥?08View Article
  10.Lee CH, Garcia HS, Parkin KL (2010) Bioactivities of kernel extracts of 18 strains of maize (Zea mays L.). J Food Sci 75:C667鈥揅672View Article
  11.Lopez-Martinez LX, Parkin KL, Garcia HS (2011) Phase II-inducing, polyphenols content and antioxidant capacity of corn (Zea mays) from phenotypes of white, blue, red and purple colors processed into masa and tortillas. Plant Foods Hum Nutr 66:41鈥?7View Article
  12.Mendoza-D铆az S, Mdel Ortiz-Valerio C, Casta帽o-Tostado E, Jde Figueroa-C谩rdenas D, Reynoso-Camacho R, Ramos-G贸mez M, Campos-Vega R, Loarca-Pi帽a G (2012) Antioxidant capacity and antimutagenic activity of anthocyanin and carotenoid extracts from nixtamalized pigmented creole maize races (Zea mays L.). Plant Foods Hum Nutr 67:442鈥?49View Article
  13.Hagiwara A, Miyashita K, Nakanishi TS et al (2001) Pronounced inhibition by a natural anthocyanin, purple corn color, of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP)-associated colorectal carcinogenesis in male F344 rats pretreated with 1,2-dimethylhydrazine. Cancer Lett 171:17鈥?5View Article
  14.Association of Official Analytical Chemists. Official methods of analysis of the AOAC (1999) 16th ed. AOAC. Washington, D.C
  15.American Association of Cereal Chemists (2000) Approved methods of analysis, 11th edn. AACC International, St. Paul
  16.Dewanto V, Wu X, Adom K, Lui R (2002) Thermal processing enhances the nutritional value of tomatoes by increasing total antioxidant activity. J Agric Food Chem 50:3010鈥?014View Article
  17.Abdel-Aal ESM, Hucl PA (1999) Rapid method for quantifying anthocyanins in blue aleurone and purple pericarp wheats. Cereal Chem 76:350鈥?54View Article
  18.Reynoso-Camacho R, Gonz谩lez-Jasso E, Ferriz-Mart铆nez R, Villal贸n-Corona B, Loarca-Pi帽a GF, Salgado LM, Ramos-Gomez M (2011) Dietary supplementation of lutein reduces colon cancer in DMH-treated rats by modulating K-ras, PKB, and 尾-catenin proteins. Nutr Cancer 63:39鈥?5
  19.Per拧e M, Cerar A (2011) Morphological and molecular alterations in 1,2 dimethylhydrazine and azoxymethane induced colon carcinogenesis in rats. J Biomed Biotechnol. doi:10.鈥?155/鈥?011/鈥?73964
  20.Habig WH, Pabst MJ, Jakoby WB (1974) Glutathione S-transferases. The first enzymatic step in mercapturic acid. J Biol Chem 249:7130鈥?139
  21.Prochaska HJ, Santamaria AB, Talalay P (1992) Rapid detection of inducers of enzymes that protect against carcinogens. Proc Natl Acad Sci U S A 89:2394鈥?398View Article
  22.Jenab M, Thompson LU (1996) The influence of flaxseed and lignans on colon carcinogenesis and beta-glucuronidase activity. Carcinogenesis 17:1343鈥?348View Article
  23.M茅ndez-Montealvo G, Solorza-Feria J, Vel谩zquez VM, G贸mez-Montiel N, Paredes-L贸pez O, Bello-P茅rez LA (2005) Composici贸n qu铆mica y caracterizaci贸n calorim茅trica de h铆bridos y variedades de ma铆z cultivadas en M茅xico. Agrociencia 39:267鈥?74
  24.Hern谩ndez-Salazar M, Agama-Acevedo E, S谩yago-Ayerdi SG, Tovar J, Bello-P茅rez LA (2006) Chemical composition and starch digestibility of tortillas prepared with non-conventional commercial nixtamalized maize flours. Int J Food Sci Nutr 57:143鈥?50View Article
  25.Kawabata K, Yamamoto T, Hara A et al (2010) Modifying effects of ferulic acid on azoxymethane-induced colon carcinogenesis in F344 rats. Cancer Lett 157:15鈥?1View Article
  26.Clarke JM, Topping DL, Bird AR, Young GP, Cobiac L (2008) Effects of high-amylose maize starch and butyrylated high-amylose maize starch on azoxymethane-induced intestinal cancer in rats. Carcinogenesis 29:2190鈥?194View Article
  27.Gregoire RC, Stern HS, Yeung KS, Stadler J, Langley S, Furrer R, Bruce WR (1989) Effect of calcium supplementation on mucosal cell proliferation in high risk patients for colon cancer. Gut 30:376鈥?82View Article
  28.Manju V, Balasubramaniyan V, Nalini N (2005) Rat colonic lipid peroxidation and antioxidant status: the effects of dietary luteolin on 1,2-dimethylhydrazine challenge. Cell Mol Biol Lett 10:535鈥?51
  29.Pool-Zobel B, Veeriah S, B枚hmer FD (2005) Modulation of xenobiotic metabolising enzymes by anticarcinogens - focus on glutathione S-transferases and their role as targets of dietary chemoprevention in colorectal carcinogenesis. Mutat Res 591:74鈥?2View Article
  30.Begleiter A, Sivananthan K, Lefas GM, Maksymiuk AW, Bird RP (2009) Inhibition of colon carcinogenesis by post-initiation induction of NQO1 in Sprague鈥揇awley rats. Oncol Rep 21:1559鈥?565View Article
  31.Llor X, Jacoby RF, Teng BB, Davidson NO, Sitrin MD, Brasitus TA (1991) K-ras mutations in 1,2-dimethylhydrazine-induced colonic tumors: effects of supplemental dietary calcium and vitamin D deficiency. Cancer Res 51:4305鈥?309
  
• 作者单位：Rosal铆a Reynoso-Camacho (1)
  Guadalupe Guerrero-Villanueva (1)
  Juan de Dios Figueroa (2)
  Marco A. Gallegos-Corona (3)
  Sandra Mendoza (1)
  Guadalupe Loarca-Pi帽a (1)
  Minerva Ramos-Gomez (1)
  
  1. Departamento de Investigaci贸n y Posgrado en Alimentos (PROPAC), Facultad de Qu铆mica, Universidad Aut贸noma de Quer茅taro, Quer茅taro, 76010, M茅xico
  2. Centro de Investigaci贸n y de Estudios Avanzados. Ciencia de Materiales. 脕rea de Materiales Bio-org谩nicos (CINVESTAV-Unidad Quer茅taro), Quer茅taro, 76230, M茅xico
  3. Laboratorio de Histopatolog铆a, Facultad de Medicina, Universidad Aut贸noma de Quer茅taro, Quer茅taro, 76017, M茅xico
  
• 刊物主题：Food Science; Chemistry/Food Science, general; Nutrition; Ecology; Plant Physiology;
• 出版者：Springer US
• ISSN：1573-9104

文摘

Mexico has the highest per capita consumption of corn in the world, which is consumed mainly as tortilla. However, only a few in vivo studies have demonstrated the anticarcinogenic potential of some maize components against colon cancer, but not as a whole food product. Therefore, our objective was to evaluate the protective effect of corn tortillas against the development of colon cancer. First, blue, red, yellow and white corn grains were lime-cooked and processed to elaborate tortillas. Then, tortillas were administered into the diet (27聽% w/w) to male Sprague鈥揇awley rats induced with the colon carcinogen 1,2-dimethylhydrazine (DMH). Our results indicated that consumption of tortillas, particularly from white and blue corns, significantly decreased adenocarcinoma incidence (up to 77.5聽%) and mean number compared to DMH-treated animals. In addition, an inhibition of 尾-glucuronidase activity, and induction of detoxifying enzymes in liver and colon, as well as a decrease in the expression of the two most important proliferative proteins (K-ras and 尾-catenin) involved in colon carcinogenesis, were also observed. These results highlight some of the molecular mechanisms related to the chemopreventive effect of tortillas, thus indicating that corn products retain their biological properties even after nixtamalization and tortilla processing.