Estrogen receptor α in cancer associated fibroblasts suppresses prostate cancer invasion via reducing CCL5, IL6 and macrophage infiltration in the tumor microenvironment

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• 作者：Chiuan-Ren Yeh ; Spencer Slavin ; Jun Da ; Iawen Hsu ; Jie Luo…
• 关键词：CAF ; ERα ; CCL5 ; IL6 ; Tumor associated macrophages ; Prostate cancer
• 刊名：Molecular Cancer
• 出版年：2016
• 出版时间：December 2016
• 年：2016
• 卷：15
• 期：1
• 全文大小：1,339 KB
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• 作者单位：Chiuan-Ren Yeh (1)
  Spencer Slavin (1)
  Jun Da (1)
  Iawen Hsu (1)
  Jie Luo (1)
  Guang-Qian Xiao (2)
  Jie Ding (1)
  Fu-Ju Chou (1)
  Shuyuan Yeh (1)
  
  1. George Whipple Lab for Cancer Research, Departments of Urology and Pathology, University of Rochester Medical Center, Rochester, NY, 14642, USA
  2. Department of Pathology, University of Rochester Medical Center, Rochester, NY, 14642, USA
  
• 刊物主题：Cancer Research; Oncology;
• 出版者：BioMed Central
• ISSN：1476-4598

文摘

Background Cancer associated fibroblasts (CAF) play important roles in tumor growth that involves inflammation and epithelial cell differentiation. Early studies suggested that estrogen receptor alpha (ERα) was expressed in stromal cells in normal prostates and prostate cancer (PCa), but the detailed functions of stromal ERα in the PCa remain to be further elucidated.