Expression of transcription factors RORC2 and FoxP3 mRNA in lymphocytes of patients with pulmonary tuberculosis

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• 作者：T. E. Kononova ; O. I. Urazova ; V. V. Novitskii ; E. G. Churina…
• 关键词：transcription factors ; RORC2 ; FoxP3 ; Th ; 17 lymphocytes ; Treg lymphocytes ; pulmonary tuberculosis
• 刊名：Cell and Tissue Biology
• 出版年：2015
• 出版时间：May 2015
• 年：2015
• 卷：9
• 期：3
• 页码：167-172
• 全文大小：141 KB
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• 作者单位：T. E. Kononova (1)
  O. I. Urazova (1)
  V. V. Novitskii (1) (2)
  E. G. Churina (1)
  P. A. Zakharovaa (1)
  
  1. Department of Pathophysiology, Siberian State Medical University, Tomsk, 634050, Russia
  2. Laboratory of Physical Processes Modeling in Biology and Medicine, National Research Tomsk State University, Tomsk, 634050, Russia
  
• 刊物主题：Cell Biology;
• 出版者：Springer US
• ISSN：1990-5203

文摘

Homeostasis of the Th17 and Treg lymphocyte subpopulations plays an important role in a holistic and coordinated process of pathogen eradication and the prevention of infection spread in the body. Studies of the molecular mechanisms that control the balance of these cells in the formation of immune deviation in the pathogenesis of infection process are especially urgent. In this paper, we present the results of studying the expression levels of transcription factors RORC2 and FoxP3 mRNA in Th17 and Treg lymphocytes, respectively, and the contents of these cells in the peripheral blood in infectious pathology (by the example of infection caused by Mycobacterium tuberculosis). It was found that the course of infiltrative (regardless of drug sensitivity of the pathogen) and disseminated drug-sensitive pulmonary tuberculosis is accompanied by Th17 polarization of the T-lymphocyte differentiation as evidenced by the increased number of CD4+CD161+IL17A+ cells in the blood combined with the increased transcription factor RORC2 mRNA expression in the lymphocytes. In disseminated drug-resistant pulmonary tuberculosis, the differentiation of T-lymphocytes is implemented mainly towards immunosuppressive Treg cells as evidenced by an increase in their blood levels combined with increased levels of transcription factor FoxP3 mRNA expression in the lymphocytes.