Soluble CD200 Correlates With Interleukin-6 Levels in Sera of COPD Patients: Potential Implication of the CD200/CD200R Axis in the Disease Course

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• 作者：Priya Sakthivel ; Angele Breithaupt ; Marcus Gereke ; David A. Copland…
• 关键词：CD200/CD200R axis ; COPD ; LPS/elastase model ; CD200 ; deficient mice ; MMP ; 9
• 刊名：Lung
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：195
• 期：1
• 页码：59-68
• 全文大小：
• 刊物类别：Medicine
• 刊物主题：Pneumology/Respiratory System;
• 出版者：Springer US
• ISSN：1432-1750
• 卷排序：195

文摘

BackgroundCOPD represents a multifactorial lung disorder with high morbidity and mortality. Despite intensive research concerning the underlying disease mechanisms, the involvement of the CD200/CD200R axis in supporting or preventing the onset of COPD has not yet been addressed. Since the CD200/CD200R axis is crucially implicated in the maintenance of pulmonary immune homeostasis, we hypothesized that it might be involved in controlling the onset of COPD.