The expression of molecule CD28 and CD38 on CD4+/CD8+ T lymphocytes in thymus and spleen elicited by Schistosoma japonicum infection in mice model

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• 作者：Na Li ; Peng-yu Ji ; Lan-gui Song ; Jun-xia Lei ; Zhi-yue Lv…
• 关键词：Schistosoma japonicum ; CD28 ; CD38 ; Lymphocytes
• 刊名：Parasitology Research
• 出版年：2015
• 出版时间：August 2015
• 年：2015
• 卷：114
• 期：8
• 页码：3047-3058
• 全文大小：4,226 KB
• 参考文献：Bean AG, Godfrey DI, Ferlin WG, Santos-Argumedo L, Parkhouse ME, Howard MC, Zlotnik A (1995) CD38 expression on mouse T cells: CD38 defines functionally distinct subsets of alpha beta TCR+CD4?/sup>CD8?/sup> thymocytes. Int Immunol 7(2):213-21PubMed View Article
  Cai XP, Zhang H, Zhang YC, Wang Y, Su C, Ji MJ, Wu HW, Zhu X, Zhang ZS, Wu GL (2006) Dynamics of CD4+CD25+ T cells in spleens and mesenteric lymph nodes of mice infected with Schistosoma japonicum. Acta Biochim Biophys Sin (Shanghai) 38(5):299-04View Article
  Cao W, Qiu ZF, Li TS (2011) Parallel decline of CD8+CD38+ lymphocytes and viremia in treated hepatitis B patients. World J Gastroenterol 17(17):2191-198PubMed Central PubMed View Article
  Caruso A, Cantalamessa A, Licenziati S, Peroni L, Prati E, Martinelli F, Canaris AD, Folghera S, Gorla R, Balsari A, Et A (1994) Expression of CD28 on CD8+ and CD4+ lymphocytes during HIV infection. Scand J Immunol 40(5):485-90PubMed View Article
  Colovai AI, Mirza M, Vlad G, Wang S, Ho E, Cortesini R, Suciu-Foca N (2003) Regulatory CD8+CD28?/sup> T cells in heart transplant recipients. Hum Immunol 64(1):31-7PubMed View Article
  Cortesini R, LeMaoult J, Ciubotariu R, Cortesini NS (2001) CD8+CD28?/sup> T suppressor cells and the induction of antigen-specific, antigen-presenting cell-mediated suppression of Th reactivity. Immunol Rev 182:201-06PubMed View Article
  Dhodapkar MV, Steinman RM (2002) Antigen-bearing immature dendritic cells induce peptide-specific CD8 (+) regulatory T cells in vivo in humans. Blood 100(1):174-77PubMed View Article
  Fenoglio D, Ferrera F, Fravega M, Balestra P, Battaglia F, Proietti M, Andrei C, Olive D, Antonio LC, Indiveri F, Filaci G (2008) Advancements on phenotypic and functional characterization of non-antigen-specific CD8+CD28?/sup> regulatory T cells. Hum Immunol 69(11):745-50PubMed View Article
  Grzych JM, Pearce E, Cheever A, Caulada ZA, Caspar P, Heiny S, Lewis F, Sher A (1991) Egg deposition is the major stimulus for the production of Th2 cytokines in murine schistosomiasis mansoni. J Immunol 146(4):1322-327PubMed
  Karagoz B, Bilgi O, Gumus M, Erikci AA, Sayan O, Turken O, Kandemir EG, Ozturk A, Yaylaci M (2010) CD8+CD28?/sup> cells and CD4+CD25+ regulatory T cells in the peripheral blood of advanced stage lung cancer patients. Med Oncol 27(1):29-3PubMed View Article
  Komocsi A, Lamprecht P, Csernok E, Mueller A, Holl-Ulrich K, Seitzer U, Moosig F, Schnabel A, Gross WL (2002) Peripheral blood and granuloma CD4(+)CD28(-) T cells are a major source of interferon-gamma and tumor necrosis factor-alpha in Wegener's granulomatosis. Am J Pathol 160(5):1717-724PubMed Central PubMed View Article
  Li HJ, Liang YS, Dai JR, Wang W, Qu GL, Li YZ, Xing YT, Tao YH, Qian K, Jia Y, Yang ZK, Wei JY (2011) Studies on resistance of schistosoma to praziquantel XIV experimental comparison of susceptibility to praziquantel between PZQ-resistant isolates and PZQ-susceptible isolates of Schistosoma japonicum in stages of adult worms, miracidia and cercariae. Zhongguo Xue Xi Chong Bing Fang Zhi Za Zhi 23(6):611-19PubMed
  Liaskou E, Jeffery LE, Trivedi PJ, Reynolds GM, Suresh S, Bruns T, Adams DH, Sansom DM, Hirschfield GM (2014) Loss of CD28 expression by liver-infiltrating T cells contributes to pathogenesis of primary sclerosing cholangitis. Gastroenterology 147(1):221-32PubMed View Article
  Liuzzo G, Kopecky SL, Frye RL, O'Fallon WM, Maseri A, Goronzy JJ, Weyand CM (1999) Perturbation of the T-cell repertoire in patients with unstable angina. Circulation 100(21):2135-139PubMed View Article
  Markovic-Plese S, Cortese I, Wandinger KP, McFarland HF, Martin R (2001) CD4+CD28?/sup> costimulation-independent T cells in multiple sclerosis. J Clin Invest 108(8):1185-194PubMed Central PubMed View Article
  McKerrow JH (1997) Cytokine induction and exploitation in schistosome infections. Parasitology 115(Suppl):107-12View Article
  Nadareishvili ZG, Li H, Wright V, Maric D, Warach S, Hallenbeck JM, Dambrosia J, Barker JL, Baird AE (2004) Elevated pro-inflammatory CD4+CD28?/sup> lymphocytes and stroke recurrence and death. Neurology 63(8):1446-451PubMed View Article
  Najafian N, Chitnis T, Salama AD, Zhu B, Benou C, Yuan X, Clarkson MR, Sayegh MH, Khoury SJ (2003) Regulatory functions of CD8+CD28?/sup> T cells in an autoimmune disease model. J Clin Invest 112(7):1037-048PubMed Central PubMed View Article
  Ning A, Wu X, Li H, Liang J, Gao Z, Shen J, Liu Z, Xu J, Hu F, Wu F, Ji P, Wu Z, Sun X (2015) Abnormal liver function in different patients with Schistosoma japonicum. Parasitol Res 114(1):85-0PubMed View Article
  Posnett DN, Vissinga CS, Pambuccian C, Wei S, Robinson MA, Kostyu D, Concannon P (1994) Level of human TCRBV3S1 (V beta 3) expression correlates with allelic polymorphism in the spacer region of the recombination signal sequence. J Exp Med 179(5):1707-711PubMed View Article
  Renner P, Popp FC, Eggenhofer E, S
• 作者单位：Na Li (1) (2) (3)
  Peng-yu Ji (2) (3)
  Lan-gui Song (2) (3)
  Jun-xia Lei (4)
  Zhi-yue Lv (2) (3)
  Zhong-dao Wu (2) (3)
  Xiao Shao (1)
  Xi Sun (2) (3)
  
  1. Department of Pathogen Biology, Guangdong Medical College, Dongguan, 523808, China
  2. Department of Parasitology, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, 510080, China
  3. Key Laboratory for Tropical Diseases Control, The Ministry of Education, Sun Yat-sen University, Guangzhou, 510080, China
  4. Center laboratory for teaching, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, 510080, China
  
• 刊物类别：Biomedical and Life Sciences
• 刊物主题：Biomedicine
  Medical Microbiology
  Microbiology
  Immunology
  
• 出版者：Springer Berlin / Heidelberg
• ISSN：1432-1955

文摘

Schistosomiasis caused by human schistosomes such as Schistosoma japonicum (S. japonicum) is considered as an immune-related disease. It was demonstrated that specific cytokine antibodies-response elicited by S. japonicum infection was gradually downregulated with the progress of the disease, resulting in a Th1/Th2 polarization and suppression of immune response. CD28 (cluster of differentiation 28) is one of the proteins expressed on T cells that provide co-stimulatory signals required for T cell activation and survival, and CD38 is an activating marker of T lymphocyte with high expression in many acute or chronic infections. The immune signature of CD28null T cells in the peripheral circulation associates with chronic inflammation in many diseases, such as HIV and CMV infection. In the thymus, CD28 expression on developing thymocytes appears to play a role for their selection, and it synergizes with CD38 to induce apoptosis of DP (double-positive) thymocytes. Few reports about CD28 and CD38 have been published in schistosomiasis. Here, we investigated the dynamic patterns of the expression of molecules CD28 and CD38 on CD4+/CD8+ T lymphocytes of the thymus and spleen in mice model with S. japonicum infection. Our data indicated that at an early period of infection, the frequency of CD8+CD28?/sup> T cell in the spleen decreased significantly, but higher at chronic infection than that in control. However, it demonstrated an increasing trend in the thymus with the progression of infection. The frequency of CD4+CD28?/sup> T cells increased from acute infection in the thymus, while from chronic infection in the spleen. The expression of CD38 on CD8+ T cells began to increase at 4?weeks post infection both in the thymus and spleen; its elevated expression on CD4+ T cells emerged at 6?weeks post infection in the thymus and at 10?weeks post infection in the spleen. Praziquantel (PZQ) treatment could partially restore the frequency of CD28+ T cell of CD4+ T cells and CD38+ T cell of CD8+/CD4+ T cells in the spleen and CD38+ T cell in the thymus. We hypothesized that the reactivation of S. japonicum infection may trigger expansion of CD28?/sup> T cells and hence mediate systemic inflammation. We speculated that CD8+CD28?/sup> T cell might be involved in immune modulation and CD8+CD28?/sup> T cell may be a crucial part in pathogenesis, which can provide further knowledge of the sophisticated mechanism of immuno-downregulation in schistosomiasis and potential treatment target.