Urine and serum ghrelin, sCD80 and sCTLA-4 levels in doxorubicin-induced experimental nephrotic syndrome

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• 作者：Duygu Ozkorucu ; Nuran Cetin ; Nadide Melike Sav…
• 刊名：International Urology and Nephrology
• 出版年：2016
• 出版时间：July 2016
• 年：2016
• 卷：48
• 期：7
• 页码：1187-1196
• 全文大小：918 KB
• 刊物类别：Medicine
• 刊物主题：Medicine & Public Health
  Nephrology
  Urology and Andrology
  
• 出版者：Springer Netherlands
• ISSN：1573-2584
• 卷排序：48

文摘

BackgroundNephrotic syndrome (NS) is an immune-mediated disorder associated with hyperlipidemia. NS has been proposed to be mediated through CD80-related T cell immune response, which could be blocked using soluble cytotoxic T lymphocyte-associated s(CTLA)-4. Although ghrelin is a hormone-modulating lipid metabolism and suppressing immune system, the precise role of ghrelin in NS is not well established.