Pathogenesis of proteinuria in idiopathic minimal change disease: molecular mechanisms

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• 作者：Gabriel Cara-Fuentes ; William L. Clapp ; Richard J. Johnson…
• 关键词：Minimal change disease ; Podocytopathy ; CD80 ; Nephrin phosphorylation ; Angiopoietin ; like 4
• 刊名：Pediatric Nephrology
• 出版年：2016
• 出版时间：December 2016
• 年：2016
• 卷：31
• 期：12
• 页码：2179-2189
• 全文大小：
• 刊物类别：Medicine
• 刊物主题：Pediatrics; Nephrology; Urology;
• 出版者：Springer Berlin Heidelberg
• ISSN：1432-198X
• 卷排序：31

文摘

Minimal change disease (MCD) is the most common type of nephrotic syndrome in children and adolescents. The pathogenesis of proteinuria in this condition is currently being reassessed. Following the Shalhoub hypothesis, most efforts have been placed on identifying the putative circulating factor, but recent advancement in podocyte biology has focused attention on the molecular changes at the glomerular capillary wall, which could explain the mechanism of proteinuria in MCD. This report critically reviews current knowledge on the different postulated mechanisms at the glomerular capillary wall level for increased permeability to plasma proteins in MCD. The report helps describe the rationale behind novel therapies and suggests future targeted therapies for MCD.