Bile acid effects are mediated by ATP release and purinergic signalling in exocrine pancreatic cells
详细信息 查看全文
- 作者：Justyna M. Kowal ; Kristian A. Haanes…
- 关键词：ATP release ; P2 receptors ; Bile acids ; CDCA ; TGR5 ; FXR ; Ca2+ ; Pancreas ; ATP sensor ; AT1.03YEMK ; FLIM ; FRET
- 刊名：Cell Communication and Signaling
- 出版年：2015
- 出版时间：December 2015
- 年：2015
- 卷：13
- 期：1
- 全文大小：2,388 KB
- 刊物主题：Cell Biology; Protein-Ligand Interactions; Receptors; Cytokines and Growth Factors;
- 出版者：BioMed Central
- ISSN：1478-811X
文摘
Background In many cells, bile acids (BAs) have a multitude of effects, some of which may be mediated by specific receptors such the TGR5 or FXR receptors. In pancreas systemic BAs, as well as intra-ductal BAs from bile reflux, can affect pancreatic secretion. Extracellular ATP and purinergic signalling are other important regulators of similar secretory mechanisms in pancreas. The aim of our study was to elucidate whether there is interplay between ATP and BA signalling.