The role of APCDD1 in epithelial rearrangement in tooth morphogenesis
详细信息 查看全文
- 作者：Sanjiv Neupane ; Wern-Joo Sohn ; Gi-Jeong Gwon ; Ki-Rim Kim…
- 关键词：APCDD1 ; Epithelial rearrangement ; Inner enamel epithelium ; Enamel knot ; Cusp patterning
- 刊名：Histochemistry and Cell Biology
- 出版年：2015
- 出版时间：October 2015
- 年：2015
- 卷：144
- 期：4
- 页码：377-387
- 全文大小：2,309 KB
- 参考文献：Biggs LC, Mikkola ML (2014) Early inductive events in ectodermal appendage morphogenesis. Semin Cell Dev Biol 25-6:11-1CrossRef PubMed
Cho SW, Lee HA, Cai J, Lee MJ, Kim JY, Ohshima H, Jung HS (2007) The primary enamel knot determines the position of the first buccal cusp in developing mice molars. Differentiation 75:441-51CrossRef PubMed
Cobourne MT, Sharpe PT (2005) Sonic hedgehog signaling and developing tooth. Curr Top Dev Biol 65:255-87CrossRef PubMed
Coin R, Lesot H, Vonesch JL, Haikel Y, Ruch JV (1999) Aspects of cell proliferation kinetics of the inner dental epithelium during mouse molar and incisor morphogenesis: a reappraisal of the role of the enamel knot area. Int J Dev Biol 43:261-67PubMed
Halbleib JM, Nelson WJ (2006) Cadherins in development: cell adhesion, sorting, and tissue morphogenesis. Genes Dev 20:3199-214CrossRef PubMed
Jarvinen E, Salazar-Ciudad I, Birchmeier W, Taketo MM, Jernvall J, Thesleff I (2006) Continuous tooth generation in mouse is induced by activated epithelial Wnt/beta-catenin signaling. Proc Natl Acad Sci USA 103:18627-8632PubMed Central CrossRef PubMed
Jernvall J, Thesleff I (2000) Reiterative signaling and patterning in mammalian tooth morphogenesis. Mech Dev 92:19-9CrossRef PubMed
Jernvall J, Thesleff I (2012) Tooth shape formation and tooth renewal: evolving with the same signals. Development 139:3487-497CrossRef PubMed
Jernvall J, Kettunen P, Karavanova I, Martin LB, Thesleff I (1994) Evidence for the role of the enamel knot as a control center in mammalian tooth cusp formation: non-dividing cells express growth stimulating Fgf-4 gene. Int J Dev Biol 38(3):463-69PubMed
Jukkola T, Sinjushina N, Partanen J (2004) Drapc1 expression during mouse embryonic development. Gene Expr Patterns 4:755-62CrossRef PubMed
Kassai Y, Munne P, Hotta Y, Penttila E, Kavanagh K, Ohbayashi N, Takada S, Thesleff I, Jernvall J, Itoh N (2005) Regulation of mammalian tooth cusp patterning by ectodin. Science 309:2067-070CrossRef PubMed
Liu F, Chu EY, Watt B, Zhang Y, Gallant NM, Andl T, Yang SH, Lu MM, Piccolo S, Schmidt-Ullrich R, Taketo MM, Morrisey EE, Atit R, Dlugosz AA, Miller SE (2008) Wnt/beta catenin signaling directs multiple stage of tooth morphogenesis. Dev Biol 313:210-24PubMed Central CrossRef PubMed
Loes S, Luukko K, Kvinnsland IH, Kettunen P (2001) Slit1 is specifically expressed in the primary and secondary enamel knots during molar tooth cusp formation. Mech Dev 107:155-57CrossRef PubMed
Martinez-Rico C, Pincet F, Thiery JP, Dufour S (2009) Integrins stimulate E-cadherin mediated intercellular adhesion by regulating Src-kinase activation and actomyocin contractility. J Cell Sci 123:712-22CrossRef
Neupane S, Sohn WJ, Rijal G, Lee YJ, Lee S, Yamamoto H, An CH, Cho SW, Lee Y, Shin HI, Kwon TY, Kim JY (2014) Developmental regulations of Perp in mice molar morphogenesis. Cell Tissue Res 358(1):109-21CrossRef PubMed
Obara N, Lesot H (2004) Subcellular localization of beta-catenin and cadherin expression in the cap-stage enamel organ of the mouse molar. Histochem Cell Biol 121:352-58CrossRef
Obara N, Lesot H (2007) Asymmetrical growth, differential cell proliferation and dynamic cell rearrangement underlie epithelial morphogenesis in mouse molar. Cell Tissue Res 330:461-73CrossRef PubMed
Otsu K, Kishigami R, Fujiwara N, Ishizeki K, Harada H (2011) Functional role of rho-kinase in ameloblast differentiation. J Cell Physiol 226:2527-534CrossRef PubMed
Palacios J, Benito N, Berraquero R, Pizarro A, Cano A, Gamallo C (1995) Differential spatiotemporal expression of E- and P-cadherin during mouse tooth development. Int J Dev Biol 39:363-66
Pispa J, Thesleff I (2003) Mechanisms of ectodermal organogenesis. Dev Biol 262(2):195-05CrossRef PubMed
Pispa J, Mustonen T, Mikkola ML, Kangas AT, Koppinen P, Lukinmaa PL, Jernvall J, Thesleff I (2004) Tooth patterning and enamel formation can be manipulated by misexpression of TNF receptor Edar. Dev Dyn 231:432-40CrossRef PubMed
Rallis C, Pinchin SM, Ish-Horowicz D (2010) Cell-autonomous integrin control of Wnt and Notch signaling during somitogenesis. Development 137:3591-601CrossRef PubMed
Salmivirta K, Gullberg D, Hirsch E, Altruda F, Ekblom P (1996) Integrin subunit expression associated with epithelial-mesenchymal interactions during murine tooth development. Dev Dyn 205(2):104-13CrossRef PubMed
Shimomura Y, Agalliu D, Vonica A, Luria V, Wajid M, Baumer A, Belli S, Petukhova L, Schinzel A, Brivanlou AH, Barres BA, Christiano AM (2010) APCDD1 is a novel Wnt inhibitor mutated in hereditary hypotrichosis simplex. Nature 464:1043-047PubMed Central CrossRef PubMed
Sohn WJ, Yamamoto H, Shin HI, Ryoo ZY, Lee S, Bae YC, Jung HS, Kim JY (2011) Importance of region specific epithelial rearrangements in mouse rugae development. Cell Tissue Res 344:271-77CrossRef PubMed
Sohn WJ, Choi MA, Yamamato H, Lee S, Lee Y, Jung JK, Jin MU, A - 作者单位：Sanjiv Neupane (1)
Wern-Joo Sohn (1)
Gi-Jeong Gwon (1)
Ki-Rim Kim (2)
Sanggyu Lee (3)
Chang-Hyeon An (4)
Jo-Young Suh (5)
Hong-In Shin (6)
Hitoshi Yamamoto (7)
Sung-Won Cho (8)
Youngkyun Lee (1)
Jae-Young Kim (1)
1. Department of Biochemistry, School of Dentistry, IHBR, Kyungpook National University, 2177 Dalgubeol-daero, Joong-gu, Daegu, 700-412, Korea
2. Department of Dental Hygiene, IHBR, Kyungpook National University, Daegu, Korea
3. School of Life Science and Biotechnology, Kyungpook National University, Daegu, Korea
4. Department of Oral and Maxillofacial Radiology, School of Dentistry, IHBR, Kyungpook National University, Daegu, Korea
5. Department of Periodontology, School of Dentistry, IHBR, Kyungpook National University, Daegu, Korea
6. Department of Oral and Maxillofacial Pathology, School of Dentistry, IHBR, Kyungpook National University, Daegu, Korea
7. Department of Histology and Developmental Biology, Tokyo Dental College, Tokyo, Japan
8. Division in Anatomy and Developmental Biology, Department of Oral Biology, Yonsei University College of Dentistry, Seoul, Korea - 刊物类别：Medicine
- 刊物主题：Medicine & Public Health
Anatomy
Medicine/Public Health, general - 出版者：Springer Berlin / Heidelberg
- ISSN：1432-119X
文摘
Adenomatosis polyposis coli downregulated 1 (APCDD1), a negative regulator of Wnt signaling, was examined to understand detailed mechanisms underlying Wnt signaling tooth development. In situ hybridization showed that Apcdd1 was expressed in the condensed mesenchyme at the bud stage, and in the inner enamel epithelium (IEE), including enamel knot (EK) at the cap stage. In vitro organ cultivation by using Apcdd1 antisense oligodeoxynucleotides was performed at E13.5 for 2 days to define the developmental functions of APCDD1 during tooth development. Analysis of histogenesis and cellular events such as cell adhesion, proliferation, apoptosis and epithelial rearrangement after Apcdd1 knockdown showed altered morphogenesis of the tooth germ with decreased cell proliferation and altered localization of cell adhesion molecules. Actin filament staining and 1,1-dioctadecyl-3,3,3-3-tetramethylindocarbocyanine perchlorate (DiI) labeling of IEE cells showed that Apcdd1 knockdown enhanced epithelial rearrangement in the IEE and EK. To understand the precise signaling regulations of Apcdd1, we evaluated the altered expression patterns of signaling molecules, related with Wnt and enamel knot signalings using RT-qPCR. Tooth germs at cap stage were transplanted into the kidney capsules and were allowed to develop into calcified teeth for 3 weeks. Apcdd1 knockdown increased the number of ectopic cusps on the mesial side of the tooth. Our results suggested that APCDD1 modulates the gene expression of Wnt- and EK-related signaling molecules at the cap stage of tooth development, and is involved in tooth cusp patterning by modulating the epithelial rearrangement in the IEE. Keywords APCDD1 Epithelial rearrangement Inner enamel epithelium Enamel knot Cusp patterning