Immunotoxicity assessment of CdSe/ZnS quantum dots in macrophages, lymphocytes and BALB/c mice

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• 作者：Xiaomei Wang ; Jinglin Tian ; Ken-Tye Yong ; Xuedan Zhu…
• 关键词：Quantum dots ; Macrophages ; Lymphocytes ; Cytotoxicity ; Immunotoxicity
• 刊名：Journal of Nanobiotechnology
• 出版年：2016
• 出版时间：December 2016
• 年：2016
• 卷：14
• 期：1
• 全文大小：8,026 KB
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• 作者单位：Xiaomei Wang (1) (2) (4)
  Jinglin Tian (1) (2)
  Ken-Tye Yong (3)
  Xuedan Zhu (2)
  Marie Chia-Mi Lin (2)
  Wenxiao Jiang (2)
  Jiefeng Li (2)
  Qijun Huang (2)
  Guimiao Lin (2) (4)
  
  1. College of Life Science and Oceanography, Shenzhen University, Shenzhen, 518060, People’s Republic of China
  2. Key Lab of Biomedical Engineering, School of Medicine, Shenzhen University, Shenzhen, 518060, People’s Republic of China
  4. The Institute of Urinary and Reproductive, Shenzhen Key lab of Translational Medicine of Tumor, The Engineering Lab of Synthetic Biology, School of Medicine, Shenzhen University, Shenzhen, 518060, People’s Republic of China
  3. School of Electrical and Electronic Engineering, Nanyang Technological University, Singapore, 639798, Singapore
  
• 刊物类别：Chemistry and Materials Science
• 刊物主题：Biotechnology
  Nanotechnology
  
• 出版者：BioMed Central
• ISSN：1477-3155

文摘

Background The toxicity of CdSe/ZnS quantum dots (QDs) in the environment and biological systems has become a major concern for the nanoparticle community. However, the potential toxicity of QDs on immune cells and its corresponding immune functions remains poorly understood. In this study, we investigated the immunotoxicity of CdSe/ZnS QDs using the in vitro in macrophages and lymphocytes and in vivo in BALB/c mice.