Effect of memory CD4⁺ T cells’ signal transducer and activator of transcription (STATs) functional shift on cytokine-releasing properties in asthma

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• 作者：Zhihong Chen ; Jue Pan ; Yi Jia ; Dandan Li ; Zhihui Min…
• 关键词：Memory CD4+ T cells ; Cytokine profiles ; Signal transducer and activator of transcription (STAT) ; Asthma ; TH2 memory cells
• 刊名：Cell Biology and Toxicology
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：33
• 期：1
• 页码：27-39
• 全文大小：
• 刊物类别：Biomedical and Life Sciences
• 刊物主题：Cell Biology; Pharmacology/Toxicology; Biochemistry, general;
• 出版者：Springer Netherlands
• ISSN：1573-6822
• 卷排序：33

文摘

BackgroundRecent data have demonstrated that long-lived memory T cells are present in the human lung and can play significant roles in the pathogenesis of specific allergic and autoimmune diseases. However, most evidence has been obtained from mouse studies, and the potential roles of memory T cells in human allergic diseases, such as asthma, remain largely unknown.