Foxp3 expression in CD4⁺CD25⁺Foxp3⁺ regulatory T cells promotes development of colorectal cancer by inhibiting tumor immunity

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• 作者：Xiao-wen Zhu 朱晓文 ; Hai-zhen Zhu 朱海珍…
• 关键词：CD4+CD25+Foxp3+ regulatory T cells ; Foxp3 ; Stat3 ; IL ; 10 ; colorectal cancer ; tumor immunity
• 刊名：Journal of Huazhong University of Science and Technology [Medical Sciences]
• 出版年：2016
• 出版时间：October 2016
• 年：2016
• 卷：36
• 期：5
• 页码：677-682
• 全文大小：812 KB
• 刊物主题：Medicine/Public Health, general;
• 出版者：Springer Berlin Heidelberg
• ISSN：1993-1352
• 卷排序：36

文摘

The mechanism underlying CD4+CD25+Foxp3+ regulatory T cells (Tregs) promoting the development of colorectal cancer (CRC) was elucidated in the present study. Forty-eight cases of colorectal carcinomas, 22 cases of colon polyps and 21 cases of normal colorectal tissues were collected. The correlation among Foxp3, IL-10 and Stat3, and the clinical relevance of these three indexes were analyzed. The results showed that the levels of Foxp3 expressed in infiltrating CD4+CD25+Foxp3+Tregs, and IL-10 and Stat3 in CRC tissues were all significantly higher than those in polypus tissues and normal colon tissues (P< 0.01). Pearson correlation analysis indicated that the expression level of Foxp3 was positively correlated with Stat3 at mRNA level (r=0.526, P=0.036), and was positively correlated with IL-10 at protein level (r=0.314, P=0.030). The Foxp3 expressed in CD4+CD25+Foxp3+Tregs was correlated with the histological grade, lymph node metastasis and TNM stage of CRC (P<0.05 for all). The IL-10 expression was correlated with the histological grade and TNM stage (both P<0.05). The Stat3 expression was correlated with the lymph node metastasis and TNM stage (both P<0.05). It was concluded that CD4+CD25+Foxp3+Tregs can inhibit tumor immunity in combination with some other related inhibitory cytokines and that Foxp3 expression in CD4+CD25+Foxp3+Tregs correlates with CRC progression.