Brown rice (Oryza sativa L. cv. Hiami) extract promotes cellular growth by upregulation of GH and IGF-1 expression and secretion

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• 作者：Hyun-seok Oh ; Se Kwan Oh ; Jum Seek Lee ; June Seek Choi…
• 关键词：brown rice ; growth ; growth hormone ; IGF ; 1 ; IGFBP ; 1
• 刊名：Food Science and Biotechnology
• 出版年：2016
• 出版时间：February 2016
• 年：2016
• 卷：25
• 期：1
• 页码：335-339
• 全文大小：310 KB
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• 作者单位：Hyun-seok Oh (1) (2)
  Se Kwan Oh (3)
  Jum Seek Lee (3)
  June Seek Choi (4)
  Sung-Joon Lee (1) (2)
  
  1. Department of Biotechnology, Graduate School of Life Sciences and Biotechnology, Korea University, Seoul, 02841, Korea
  2. Department of Food Bioscience and Technology, College of Life Sciences and Biotechnology, Korea University, Seoul, 02841, Korea
  3. Rice Research Division, National Institute of Crop Science, Rural Development Administration, Suwon, Gyeonggi, 16429, Korea
  4. Deparment of Psychology, Department of Psychology, Korea University, Seoul, 02841, Korea
  
• 刊物类别：Chemistry and Materials Science
• 刊物主题：Chemistry
  Nutrition
  Food Science
  
• 出版者：The Korean Society of Food Science and Technology in co-publication with Springer
• ISSN：2092-6456

文摘

The effects of the ethanolic extract of brown rice (BRE, Oryza sativa L. cv. Hiami) on cellular growth were investigated. Gene expression analysis by qPCR showed that the expression of the mRNA expressions of growth hormone (GH) and insulin-like growth factor (IGF)-1 genes was significantly induced in cells stimulated with BRE compared with controls, and the effects were dose dependent. In addition, the hormone secretion of GH and IGF-1 was significantly induced in GH3 and HepG2 cells stimulated with BRE in line with the qPCR results. Collectively, these results suggest that BRE induces the expression and secretion of GH and IGF-1 in vitro; therefore, application may promote cellular growth.