NK Cells in HIV Disease

详细信息    查看全文

• 作者：Eileen Scully ; Galit Alter
• 关键词：HIV ; Innate immunity ; NK cell ; Antibody ; dependent cellular cytotoxicity ; NK cell memory ; Natural killer (NK) ; Viral immunity ; HIV pathogenesis ; Review
• 刊名：Current HIV/AIDS Reports
• 出版年：2016
• 出版时间：April 2016
• 年：2016
• 卷：13
• 期：2
• 页码：85-94
• 全文大小：421 KB
• 刊物主题：Medicine/Public Health, general;
• 出版者：Springer US
• ISSN：1548-3576

文摘

Natural killer (NK) cells play a critical role in viral immunity. In the setting of HIV infection, epidemiologic and functional evidence support a role for NK cells in both protection from new infection and in viral control. Specifically, NK cells directly mediate immune pressure leading to virus evolution, and NK cell receptor genotypic profiles, clonal repertoires, and functional capacity have all been implicated in virus containment. In addition, indirect NK cell-mediated antibody-dependent cellular cytotoxicity has been linked to vaccine-induced protective immunity against HIV infection. With recent advances in our understanding of NK cell deficiency, development, memory-like responses, and editing of the adaptive immune system, the opportunities to direct and exploit NK cell antiviral immunity to target HIV have exponentially grown. In this review, we seek to highlight the intersections between discoveries in basic NK cell biology and the challenges of HIV chronic infection, vaccine development, and cure/eradication strategies.