Cellular immune activity biomarker neopterin is associated hyperlipidemia: results from a large population-based study
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- 作者：Shu-Chun Chuang ; Heiner Boeing ; Stein Emil Vollset ; Øivind Midttun…
- 关键词：Neopterin ; Cell ; mediated immunity ; Metabolic syndrome
- 刊名：Immunity & Ageing
- 出版年：2016
- 出版时间：December 2016
- 年：2016
- 卷：13
- 期：1
- 全文大小：563 KB
- 刊物主题：Immunology; Geriatrics/Gerontology; Aging;
- 出版者：BioMed Central
- ISSN：1742-4933
文摘
Background Increased serum neopterin had been described in older age two decades ago. Neopterin is a biomarker of systemic adaptive immune activation that could be potentially implicated in metabolic syndrome (MetS). Measurements of waist circumference, triglycerides, high-density lipoprotein cholesterol (HDLC), systolic and diastolic blood pressure, glycated hemoglobin as components of MetS definition, and plasma total neopterin concentrations were performed in 594 participants recruited in the European Prospective Investigation into Cancer and Nutrition (EPIC).