Metabolites: deciphering the molecular language between DCs and their environment
详细信息 查看全文
- 作者：Lucía Minarrieta ; Peyman Ghorbani ; Tim Sparwasser…
- 关键词：Dendritic cells ; Metabolites ; Metabolism ; Vitamins ; Tolerance ; Microbiota
- 刊名：Seminars in Immunopathology
- 出版年：2017
- 出版时间：February 2017
- 年：2017
- 卷：39
- 期：2
- 页码：177-198
- 全文大小：
- 刊物类别：Biomedical and Life Sciences
- 刊物主题：Immunology; Internal Medicine;
- 出版者：Springer Berlin Heidelberg
- ISSN：1863-2300
- 卷排序：39
文摘
Dendritic cells (DCs) determine the outcome of the immune response based on signals they receive from the environment. Presentation of antigen under various contexts can lead to activation and differentiation of T cells for immunity or dampening of immune responses by establishing tolerance, primarily through the priming of regulatory T cells. Infections, inflammation and normal cellular interactions shape DC responses through direct contact or via cytokine signaling. Although it is widely accepted that DCs sense microbial components through pattern recognition receptors (PRRs), increasing evidence advocates for the existence of a set of signals that can profoundly shape DC function via PRR-independent pathways. This diverse group of host- or commensal-derived metabolites represents a newly appreciated code from which DCs can interpret environmental cues. In this review, we discuss the existing information on the effect of some of the most studied metabolites on DC function, together with the implications this may have in immune-mediated diseases.