Investigation on release of highly water soluble drug from matrix-coated pellets prepared by extrusion–spheronization technique
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- 作者：Muhammad Iqbal Nasiri ; Rabia Ismail Yousuf…
- 关键词：Itopride hydrochloride ; Pellets ; Ethyl cellulose ; Extended release ; Extrusion–spheronization
- 刊名：Journal of Coatings Technology and Research
- 出版年：2016
- 出版时间：March 2016
- 年：2016
- 卷：13
- 期：2
- 页码：333-344
- 全文大小：1,246 KB
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Rabia Ismail Yousuf (1)
Muhammad Harris Shoaib (1)
Muhammad Fayyaz (1)
Faaiza Qazi (1)
Kamran Ahmed (1)
1. Department of Pharmaceutics, Faculty of Pharmacy, University of Karachi, Karachi, Pakistan - 刊物类别：Chemistry and Materials Science
- 刊物主题：Chemistry
Tribology, Corrosion and Coatings
Surfaces and Interfaces and Thin Films
Polymer Sciences
Materials Science - 出版者：Springer US
- ISSN：1935-3804
文摘
The objective was to formulate itopride HCl (ITP) extended release matrix-coated pellets by extrusion–spheronization and to investigate the influence of concentration and viscosity grade of different polymers on release of a highly water soluble drug. The matrix pellet formulations consisted of polymers (10–30%) like hydroxypropyl methylcellulose (HPMC K4M, K15M, and K100M), ethyl cellulose (EC-7 cps), microcrystalline cellulose (10–30%) and a fixed quantity of lactose (10%). The initial fast drug release from the matrix pellets was effectively controlled by coating with 5% ethyl cellulose (10 cps) dispersion. The dissolution studies of coated formulations were carried out at different pH, and data were analyzed for drug release kinetics. Scanning electron microscope was used to examine the surface morphology and cross section of pellets. Kinetics of all coated formulations were best explained by Higuchi model (R 2 = 0.94–0.99). However, HPMC matrix-coated pellets (F1, F4 and F7) also followed Baker and Lonsdale model (R 2 = 0.96–0.99), whereas, EC matrix-coated pellets (F10) followed zero-order kinetics (R 2 = 0.99). Release mechanism of all coated formulations was non-fickian. Both uncoated and coated pellets were found to be spherical. Fourier transform infrared spectroscopy was conducted on the coated formulations and no drug–excipients interaction was found.