The Second Brain: Is the Gut Microbiota a Link Between Obesity and Central Nervous System Disorders?
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  • 作者：Javier Ochoa-Repáraz ; Lloyd H. Kasper
  • 关键词：Gut microbiota ; Dysbiosis ; Diet ; Obesity ; Gut ; brain axis ; CNS diseases
  • 刊名：Current Obesity Reports
  • 出版年：2016
  • 出版时间：March 2016
  • 年：2016
  • 卷：5
  • 期：1
  • 页码：51-64
  • 全文大小：829 KB
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  • 作者单位：Javier Ochoa-Repáraz (1)
    Lloyd H. Kasper (2)

    1. Department of Biology, Eastern Washington University, Cheney, WA, 99004, USA
    2. Department of Microbiology and Immunology, Geisel School of Medicine at Dartmouth College, Hanover, NH, 03755, USA
  • 刊物主题：Endocrinology; Medicine/Public Health, general; Metabolic Diseases; Diabetes; Cardiology; Behavioral Therapy;
  • 出版者：Springer US
  • ISSN：2162-4968
    • 文摘
    The gut-brain axis is a bi-directional integrated system composed by immune, endocrine, and neuronal components by which the gap between the gut microbiota and the brain is significantly impacted. An increasing number of different gut microbial species are now postulated to regulate brain function in health and disease. The westernized diet is hypothesized to be the cause of the current obesity levels in many countries, a major socio-economical health problem. Experimental and epidemiological evidence suggest that the gut microbiota is responsible for significant immunologic, neuronal, and endocrine changes that lead to obesity. We hypothesize that the gut microbiota, and changes associated with diet, affect the gut-brain axis and may possibly contribute to the development of mental illness. In this review, we discuss the links between diet, gut dysbiosis, obesity, and immunologic and neurologic diseases that impact brain function and behavior.

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