Symptomatic spinal cord metastasis from cerebral oligodendroglioma

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• 作者：A. Elefante (2) andrea.elefante@unina.it
  C. Peca (1)
  M. L. Del Basso De Caro (3)
  C. Russo (2)
  F. Formicola (2)
  G. Mariniello (1)
  A. Brunetti (2)
  F. Maiuri (1)
• 关键词：Brain glioma &#8211 ; Oligodendroglioma &#8211 ; Spinal metastasis &#8211 ; Cerebrospinal fluid spread
• 刊名：Neurological Sciences
• 出版年：2012
• 出版时间：June 2012
• 年：2012
• 卷：33
• 期：3
• 页码：609-613
• 全文大小：290.1 KB
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• 作者单位：1. Neurosurgical Clinic, Department of Neurological Science, School of Medicine, University Federico II, Via Pansini 5, 80131 Naples, Italy2. Neuroradiology, Department of Diagnostic Imaging, School of Medicine, University Federico II, Via Pansini 5, 80131 Naples, Italy3. Department of Biomorphological and Functional Sciences, Section of Pathology, School of Medicine, University Federico II, Via Pansini 5, 80131 Naples, Italy
• 刊物类别：Medicine
• 刊物主题：Medicine & Public Health
  Neurology
  Neuroradiology
  Neurosurgery
  Psychiatry
  
• 出版者：Springer Milan
• ISSN：1590-3478

文摘

Spinal subarachnoid spread is not uncommon in brain oligodendrogliomas; on the other hand, symptomatic involvement of the spinal cord and cauda is very rare, with only 16 reported cases. We report the case of a 41-year-old man who underwent resection of a low-grade frontal oligodendroglioma 4 years previously. He was again observed because of bilateral sciatic pain followed by left leg paresis. A spine MRI showed an intramedullary T12–L1 tumor with root enhancement. At operation, an intramedullary anaplastic oligodendroglioma with left exophytic component was found and partially resected. Two weeks later, a large left frontoparietal anaplastic oligodendroglioma was diagnosed and completely resected. The patient was neurologically stable for 8 months and died 1 year after the spinal surgery because of diffuse brain and spinal leptomeningeal spread. The review of the reported cases shows that spinal symptomatic metastases can occur in both low-grade and anaplastic oligodendrogliomas, even many years after surgery of the primary tumor; however, they exceptionally occur as first clinical manifestation or as anaplastic progression. The spinal seeding represents a negative event leading to a short survival.