Impact of passive smoking on uterine, umbilical, and fetal middle cerebral artery blood flows

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• 作者：Sema Yildiz (1)
  Sibel Sezer (1)
  Hakan Boyar (2)
  Hasan Cece (1)
  Salih Zeki Ziylan (1)
  Mehmet Vural (3)
  Ozlem Turksoy (4)
  
• 关键词：Doppler ultrasonography ; Fetal middle cerebral artery ; Passive maternal smoking ; Umbilical artery ; Uterine artery
• 刊名：Japanese Journal of Radiology
• 出版年：2011
• 出版时间：December 2011
• 年：2011
• 卷：29
• 期：10
• 页码：718-724
• 全文大小：283KB
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• 作者单位：Sema Yildiz (1)
  Sibel Sezer (1)
  Hakan Boyar (2)
  Hasan Cece (1)
  Salih Zeki Ziylan (1)
  Mehmet Vural (3)
  Ozlem Turksoy (4)
  
  1. Department of Radiology, Harran University School of Medicine, Sanliurfa, 63100, Turkey
  2. Department of Obstetrics, Sanliurfa Maternity Hospital, Sanliurfa, Turkey
  3. Department of Obstetrics and Gynecology, Harran University School of Medicine, Sanliurfa, Turkey
  4. Department of Radiology, Zonguldak Karaelmas University School of Medicine, Zonguldak, Turkey
  

文摘

Purpose The aim of this study was to evaluate the influence of passive maternal smoking on blood flow velocities in arteries of the fetal-placental-maternal circulation. Materials and methods A total of 79 pregnant women in their third trimester, including 33 passive smokers, 23 active smokers, and 23 nonsmoking controls, were enrolled in the study. Fetal biophysical indices were evaluated with B-mode scanning, whereas blood flow waveforms of uterine, umbilical, and fetal middle cerebral (MCA) arteries were analyzed with Doppler ultrasonography. Results There were significant differences among active smokers vs. passive smokers vs. controls with regard to the presence of a uterine artery diastolic notch (39.1% vs. 18.2% vs. 4.3%; P = 0.012); ratio of peak systolic/end-diastolic velocity of fetal MCA [3.73 ± 1.27 vs. 4.26 ± 1.20 vs. 5.00 ± 2.15, analysis of variance (ANOVA) P = 0.026]; resistance index of fetal MCA (0.74 ± 0.08 vs. 0.75 ± 0.07 vs. 0.80 ± 0.09; ANOVA P = 0.014); ratio of fetal MCA/umbilical artery resistance index (1.27 ± 0.20 vs. 1.24 ± 0.14 vs. 1.39 ± 0.21; ANOVA P = 0.011); and ratio of fetal MCA/umbilical artery pulsatility index (1.56 ± 0.44 vs. 1.63 ± 0.43 vs. 1.97 ± 0.54; ANOVA P = 0.046). Conclusion Effects of passive maternal smoking on the fetal-placental-maternal unit were comparable to those with active maternal smoking as determined by the means of increased resistance in the maternal vasculature and adaptive changes of cerebroplacental circulation for maintaining fetal cerebral circulation.