Hypersensitivity to Aspirin and other NSAIDs: Diagnostic Approach in Patients with Chronic Rhinosinusitis

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• 作者：Joanna Makowska ; Anna Lewandowska–Polak…
• 关键词：Chronic rhinosinusitis ; Aspirin ; NERD ; Drug challenges
• 刊名：Current Allergy and Asthma Reports
• 出版年：2015
• 出版时间：August 2015
• 年：2015
• 卷：15
• 期：8
• 全文大小：566 KB
• 参考文献：Papers of particular interest, published recently, have been highlighted as: -Of importance1.Kowalski ML, Makowska JS, Blanca M, Bavbek S, Bochenek G, Bousquet J, et al. Hypersensitivity to nonsteroidal anti-inflammatory drugs (NSAIDs)—classification, diagnosis and management: review of the EAACI/ENDA(#) and GA2LEN/HANNA*. Allergy. 2011;66:818-9.PubMed View Article
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  20.Kowalski ML, Ptasinska A, Bienkiewicz B, Pawliczak R, DuBuske L. Differential effects of aspirin and misoprostol on 15-hydroxyeicosatetraenoic acid generation by leukocytes from aspirin-sensitive asthmatic patients. J Allergy Cli
• 作者单位：Joanna Makowska (1)
  Anna Lewandowska–Polak (1)
  Marek L. Kowalski (1)
  
  1. Department of Immunology, Rheumatology and Allergy, Healthy Ageing Research Center, Medical University of ?ód?, 251 Pomorska Str., 92-213, ?ód?, Poland
  
• 刊物主题：Allergology;
• 出版者：Springer US
• ISSN：1534-6315

文摘

Hypersensitivity to nonsteroidal anti-inflammatory drugs (NSAIDs) associated with chronic rhinosinusitis (CRS) and/or asthma comprises a distinct clinical syndrome referred to as NSAIDs exacerbated respiratory disease (NERD). Patients with NERD tend to have more severe course of both upper (CRS and nasal polyps) and lower airway (asthma) diseases and are usually recalcitrant to conventional treatment modalities. Diagnosing and phenotyping of patients with NERD are critical for prevention of drug-induced adverse reactions and open novel options for management of underlying chronic airway inflammatory diseases. Diagnosis of NERD is based on detailed clinical history confirmed by challenge with aspirin, but new diagnostic approaches are currently being developed. This review article focuses on the diagnostic approach to a patient with CRS and hypersensitivity to NSAIDs, emphasizing the importance of diagnosis for proper patient’s management.