Anxiolytic effects of muscarinic acetylcholine receptors agonist oxotremorine in chronically stressed rats and related changes in BDNF and FGF2 levels in the hippocampus and prefrontal cortex

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• 作者：Valentina Di Liberto ; Monica Frinchi ; Vincenzo Verdi ; Angela Vitale…
• 关键词：Cerebral cortex ; Chronic restraint stress ; Forced swimming test ; Novelty suppressed feeding test ; Elevated plus maze test ; mAChR ; Anxiety ; Neurotrophins ; Behavioral test
• 刊名：Psychopharmacology
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：234
• 期：4
• 页码：559-573
• 全文大小：
• 刊物类别：Biomedical and Life Sciences
• 刊物主题：Neurosciences; Pharmacology/Toxicology; Psychiatry;
• 出版者：Springer Berlin Heidelberg
• ISSN：1432-2072
• 卷排序：234

文摘

RationaleIn depressive disorders, one of the mechanisms proposed for antidepressant drugs is the enhancement of synaptic plasticity in the hippocampus and cerebral cortex. Previously, we showed that the muscarinic acetylcholine receptor (mAChR) agonist oxotremorine (Oxo) increases neuronal plasticity in hippocampal neurons via FGFR1 transactivation.