The modification and variants of histone
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- 作者：Changjun Mu ; Heng Liu and Guo-Chang Zheng
- 关键词：histone ; acetylation ; methylation ; phosphorylation ; ubiquitination ; variants
- 刊名：Molecular Biology
- 出版年：2007
- 出版时间：June, 2007
- 年：2007
- 卷：41
- 期：3
- 页码：349-360
- 全文大小：197 KB
文摘
The modification of histone plays a crucial role in regulating chromatin states that conserve transcription programs and provide a mechanism for chromatin states to be maintained as cells proliferate. A large number of factors and protein complexes are now known to be involved in regulating the dynamic states of the modification and variants of histone. A fraction of histones are nonallelic variants that have a specific expression, localization, and species-distribution patterns. Here we discuss recent progress in understanding how histone variants lead to changes in chromatin structure and dynamics to carry out specific functions.