Expression of costimulatory molecules B7-H1, B7-H4 and Foxp3+ Tregs in gastric cancer and its clinical significance

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• 作者：Yiting Geng ; Hui Wang ; Changqing Lu ; Qing Li…
• 关键词：Gastric cancer ; B7 ; H1 ; B7 ; H4 ; Foxp3 ; Tregs ; Costimulatory molecule
• 刊名：International Journal of Clinical Oncology
• 出版年：2015
• 出版时间：April 2015
• 年：2015
• 卷：20
• 期：2
• 页码：273-281
• 全文大小：1,270 KB
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  19. Wang, HY
• 刊物类别：Medicine
• 刊物主题：Medicine & Public Health
  Oncology
  Surgical Oncology
  Radiotherapy
  Diagnostic Radiology
  Internal Medicine
  Pathology
  
• 出版者：Springer Japan
• ISSN：1437-7772

文摘

Objective Immune escape plays an important role in tumor progression. In the present study, the expression of B7-H1, B7-H4 and Foxp3 involved in immune escape in gastric carcinoma was investigated and the corresponding clinical significance was evaluated. Methods Immunohistochemistry was used to detect the expression of B7-H1, B7-H4 and Foxp3 in 100 gastric cancer specimens, and 30 paracarcinoma tissues were used as the control. Results Both B7-H1 and B7-H4 showed high expression levels in gastric cancer tissues (65.0 and 71.0?%, respectively), and the expressions of B7-H1 and B7-H4 were positively correlated with the depth of tumor invasion, lymph node metastasis and American Joint Committee on Cancer (AJCC) stage (P?+ Tregs was much higher in gastric cancer tissues than control tissues, which was positively correlated with lymph node metastasis (P?+ Tregs was observed. The median overall survival rate of patients with high expression of B7-H1, B7-H4 and Foxp3 was significantly poorer than that of patients with low expression of these proteins (P?AJCC stage, and B7-H1 and Foxp3 overexpression were independent prognostic factors. Conclusion B7-H1, B7-H4 and Foxp3 were overexpressed in gastric cancer tissues. B7-H1 and Foxp3 are negative prognostic factors for patients with gastric cancer.