The autopsy study of 553 cases of sudden cardiac death in Chinese adults

详细信息    查看全文

• 作者：Hongyue Wang (1)
  Qingsong Yao (2)
  Shaohua Zhu (3)
  Guohua Zhang (4)
  Zhenyuan Wang (5)
  Zhen Li (6)
  Rongchao Sun (7)
  Changli Lu (8)
  Changrong Li (9)
  Jielin Pu (1)
  
• 关键词：Sudden cardiac death ; Autopsy ; Coronary artery disease ; Myocarditis
• 刊名：Heart and Vessels
• 出版年：2014
• 出版时间：July 2014
• 年：2014
• 卷：29
• 期：4
• 页码：486-495
• 全文大小：371 KB
• 参考文献：1. Hua W, Zhang LF, Wu YF, Liu XQ, Guo DS, Zhou HL, Gou ZP, Zhao LC, Niu H, Chen KP, Mai JZ, Chu LN, Zhang S (2009) Incidence of sudden cardiac death in China analysis of 4 regional populations. J Am Coll Cardiol 54:1110-118 CrossRef
  2. Zipes DP, Camm AJ, Borggrefe M, Buxton AE, Chaitman B, Fromer M, Gregoratos G, Klein G, Moss AJ, Myerburg RJ, Priori SG, Quinones MA, Roden DM, Silka MJ, Tracy C (2006) ACC/AHA/ESC 2006 guidelines for management of patients with ventricular arrhythmias and the prevention of sudden cardiac death: a report of the American College of Cardiology/American Heart Association Task Force and the European Society of Cardiology Committee for Practice Guidelines (Writing Committee to Develop Guidelines for Management of Patients With Ventricular Arrhythmias and the Prevention of Sudden Cardiac Death): Developed in Collaboration With the European Heart Rhythm Association and the Heart Rhythm Society. Circulation 114:e385–e484 CrossRef
  3. Tunstall-Pedoe H, Kuulasmaa K, Amouyel P, Arveiler D, Rajakangas A-M, Pajak A (1994) Myocardial infarction and coronary deaths in the World Health Organization MONICA Project: registration procedures, event rates, and case-fatality rates in 38 populations from 21 countries in four continents. Circulation 90:583-12 CrossRef
  4. di Gioia CRT, Autore C, Romeo DM, Ciallella C, Aromatario MR, Lopez A, Pagannone E, Giordano C, Gallo P, d’Amati G (2006) Sudden cardiac death in younger adults: autopsy diagnosis as a tool for preventive medicine. Hum Pathol 37:794-01 CrossRef
  5. Wu Z, Yao C, Zhao D, Wu G, Wang W, Liu J, Zeng Z, Wu Y (2001) Sino-MONICA project a collaborative study on trends and determinants in cardiovascular diseases in China, part I: morbidity and mortality monitoring. Circulation 103:462-68 CrossRef
  6. Editorial Board (1998) Conference on the importance of autopsy under modern medical conditions. Zhonghua Yixue Zazhi (National J Med China) 78:649-52 [in Chinese]
  7. Basso C, Burke M, Fornes P, Gallagher PJ, de Gouveia RH, Sheppard M, Thiene G, van der Wal A, on behalf of the Association for European Cardiovascular Pathologists (2008) Guidelines for autopsy investigation of sudden cardiac death. Virchows Arch 452:11-8 CrossRef
  8. Huang GZ (2002) GA/T170-1997 The standards for public security pathological examination of sudden deaths. In: The Bureau of Science and Technology Ministry of Public Security (eds) The collections of standards for social and public security category of criminal science and forensic examination. China Standards Press, Beijing, pp 51-3 [in Chinese]
  9. Song Y, Zhu J, Laaksonen H, Saukko P (1997) A modified method for examining the cardiac conduction system. Forensic Sci Intl 86:135-38 CrossRef
  10. Eckart RE, Shry EA, Burke AP, McNear JA, Appel DA, Castillo-Rojas LM, Avedissian L, Pearse LA, Potter RN, Tremaine L, Gentlesk PJ, Huffer L, Reich SS, Stevenson WG (2011) Sudden death in young adults: an autopsy-based series of a population undergoing active surveillance. J Am Coll Cardiol 58:1254-261 CrossRef
  11. Aretz HT (1987) Myocarditis: the Dallas criteria. Hum Pathol 18:619-24 CrossRef
  12. Knight B (1991) Forensic pathology. Edward Arnold, London, pp 487-16
  13. Drory Y, Turetz Y, Hiss Y, Lev B, Fisman E, Pines A, Kramer M (1991) Sudden unexpected death in persons less than 40?years of age. Am J Cardiol 68:1388-392 CrossRef
  14. Basso C, Thiene G, Corrado D (1996) Arrhythmogenic right ventricular cardiomyopathy dysplasia, dystrophy, or myocarditis? Circulation 94:983-91 CrossRef
  15. Basso C, Thiene G (2005) Adipositas cordis, fatty infiltration of the right ventricle, and arrhythmogenic right ventricular cardiomyopathy. Just a matter of fat? Cardiovasc Pathol 14:37-1 CrossRef
  16. Soilleux EJ, Burke MM (2009) Pathology and investigation of potentially hereditary sudden cardiac death syndromes in structurally normal hearts. Diagn Histopathol (Oxf) 15:1-6 CrossRef
  17. Basso C, Calabrese F, Corrado D, Thiene G (2001) Postmortem diagnosis in sudden cardiac death victims: macroscopic, microscopic and molecular findings. Cardiovasc Res 50:290-00 CrossRef
  18. Burke AP, Farb A, Virmani R, Goodin J, Smialek JE (1991) Sports-related and non-sports-related sudden cardiac death in young adults. Am Heart J 121:568-75 CrossRef
  19. Doolan A, Langlois N, Semsarian C (2004) Causes of sudden cardiac death in young Australians. Med J Australia 180:110-12
  20. Morentina B, Audicanab C (2011) Population-based study of out-of-hospital sudden cardiovascular death: incidence and causes of death in middle-aged adults. Rev Esp Cardiol 64:28-4 CrossRef
  21. Bowker TJ, Wood DA, Davies MJ, Sheppard MN, Cary NRB, Burton JDK, Chambers DR, Dawling S, Hobson HL, Pyke SDM, Riemersma RA, Thompson SG (2003) Sudden, unexpected cardiac or unexplained death in England: a national survey. Q J Med 96:269-79 CrossRef
  22. Chugh SS, Reinier K, Teodorescu C, Evanado A, Kehr E, Samara MA, Mariani R, Gunson K, Jui J (2008) Epidemiology of sudden cardiac death: clinical and research implications. Prog Cardiovasc Dis 51:213-28 CrossRef
  23. Zipes DP, Wellens HJJ (1998) Sudden cardiac death. Circulation 98:2334-351 CrossRef
  24. Moore MJ, Glover BM, McCann CJ, Cromie NA, Ferguson P, Catney DC, Kee F, Adgey AAJ (2006) Demographic and temporal trends in out of hospital sudden cardiac death in Belfast. Heart 92:311-15 CrossRef
  25. Corrado D, Basso C, Rizzoli G, Schiavon M, Thiene G (2003) Does sports activity enhance the risk of sudden death in adolescents and young adults? J Am Coll Cardiol 42:1959-963 CrossRef
  26. Winkel BG, Holst AG, Theilade J, Kristensen IB, Thomsen JL, Ottesen GL, Bundgaard H, Svendsen JH, Hauns? S, Tfelt-Hansen J (2011) Nationwide study of sudden cardiac death in persons aged 1-5?years. Eur Heart J 32:983-90 CrossRef
  27. Zheng Z-J, Croft JB, Giles WH, Mensah GA (2001) Sudden cardiac death in the United States, 1989 to 1998. Circulation 104:2158-163 CrossRef
  28. Fontaine G, Fornes P, Fontaliran F, Zipes DP, Wellens HJJ (2001) Myocarditis as a cause of sudden death. Circulation 103:e12 CrossRef
  29. Abe T, Tsuda E, Miyazaki A, Ishibashi-Ueda H, Yamada O (2012) Clinical characteristics and long-term outcome of acute myocarditis in children. Heart Vessels. doi:10.1007/s00380-00012-00296-00388
  30. Ikeda N, Nakamura M, Yazaki Y, Ono T, Yamamoto M, Ito S, Yokouchi I, Yajima S, Iijima R, Hara H, Takagi T, Hara H, Asahara T, Sakai H, Sugi K (2011) A slightly elevated level of N-terminal pro-brain natriuretic peptide can predict coronary artery disease in a population with normal left ventricular function. Heart Vessels 26:473-79 CrossRef
  31. Tester DJ, Ackerman MJ (2006) The role of molecular autopsy in unexplained sudden cardiac death. Curr Opin Cardiol 21:166-72 CrossRef
  32. Ackerman MJ, Priori SG, Willems S, Berul C, Brugada R, Calkins H, Camm AJ, Ellinor PT, Gollob M, Hamilton R, Hershberger RE, Judge DP, Le Marec H, McKenna WJ, Schulze-Bahr E, Semsarian C, Towbin JA, Watkins H, Wilde A, Wolpert C, Zipes DP (2011) HRS/EHRA expert consensus statement on the state of genetic testing for the channelopathies and cardiomyopathies. Europace 13:1077-109 CrossRef
  33. Davies MJ (1999) The investigation of sudden cardiac death. Histopathology 34:93-8 CrossRef
  34. Ahronheim JC, Bernholc AS, Clark WD (1983) Age trends in autopsy rates, striking decline in late life. JAMA 250:1182-186 CrossRef
  35. Smilowitz NR, Sampson BA, Abrecht CR, Siegfried JS, Hochman JS, Reynolds HR (2011) Women have less severe and extensive coronary atherosclerosis in fatal cases of ischemic heart disease: an autopsy study. Am Heart J 161:681-88 CrossRef
  
• 作者单位：Hongyue Wang (1)
  Qingsong Yao (2)
  Shaohua Zhu (3)
  Guohua Zhang (4)
  Zhenyuan Wang (5)
  Zhen Li (6)
  Rongchao Sun (7)
  Changli Lu (8)
  Changrong Li (9)
  Jielin Pu (1)
  
  1. Department of Pathology and Physiology, State Key Laboratory of Cardiovascular Disease, Fuwai Hospital and Cardiovascular Institute, Chinese Academy of Medical Sciences and Peking Union Medical College, No. 167 Beilishilu Road, Xicheng District, Beijing, 100037, China
  2. Guangzhou Institute of Criminal Technology, Guangzhou, China
  3. Department of Forensic Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
  4. School of Forensic Medicine, China Medical University, Shenyang, China
  5. Department of Forensic Medicine, Xian Jiangtong University School Medicine, Xi’an, China
  6. Department of Forensic Medicine, Kunming Medical University, Kunming, China
  7. Department of Pathology, Wuxi People’s Hospital, Nanjing Medical University, Wuxi, China
  8. Department of Pathology, West China Hospital, Sichuan University, Chengdu, China
  9. Forensic Medical Examination Center of Beijing Public Security Bureau, Beijing, China
  
• ISSN：1615-2573

文摘

Despite a recent epidemiological study reporting a lower incidence of sudden cardiac death (SCD) in China as compared with that in Western countries, the exact causes of SCD are still unknown. Using a uniform review protocol and diagnostic criteria, a retrospective autopsy study identified 553 cases of SCD in 14,487 consecutive autopsies from eight regions in China representing different geographic and population features. Their ages ranged from 18 to 80?years (median 43.0?years) with a ratio of 4.3/1.0 for male/female. Out-of-hospital deaths and unwitnessed cases accounted for 74.3 and 22.6?%, respectively. The main causes of death were coronary atherosclerotic disease (CAD 50.3?%), myocarditis (14.8?%), and hypertrophic cardiomyopathy (4.5?%), with unexplained sudden death accounting for 12.1?% of the cases. CAD had a proportion of 10.4?% in victims