Resveratrol Protects PC12 Cells from High Glucose-Induced Neurotoxicity Via PI3K/Akt/FoxO3a Pathway

详细信息    查看全文

• 作者：Mi-Hua Liu (1)
  Cong Yuan (3)
  Jun He (1)
  Tian-Ping Tan (1)
  Shao-Jian Wu (1)
  Hong-Yun Fu (1)
  Jun Liu (1)
  Shan Yu (1)
  Yu-Dan Chen (1)
  Qun-Fang Le (1)
  Wei Tian (1)
  Heng-Jing Hu (4)
  Yuan Zhang (5)
  Xiao-Long Lin (2)
  
  1. Department of Clinical Laboratory ; Affiliated Nanhua Hospital ; University of South China ; No. 336 Dongfeng South Road ; Hengyang ; 421001 ; Hunan Province ; People鈥檚 Republic of China
  3. Department of Cardiology ; The First Hospital of Changsha ; Changsha City ; 410005 ; Hunan Province ; People鈥檚 Republic of China
  4. Department of Cardiology/Cardiac Catheterisation Lab ; Second Xiangya Hospital ; Central South University ; Changsha City ; 410011 ; Hunan Province ; People鈥檚 Republic of China
  5. Department of Pathology ; Mawangdui Hospital ; Changsha City ; 410016 ; Hunan Province ; People鈥檚 Republic of China
  2. Department of Pathology ; The Third People鈥檚 Hospital of Huizhou ; Huizhou City ; 516002 ; Guangdong Province ; People鈥檚 Republic of China
  
• 关键词：Resveratrol ; High glucose ; Oxidative stress ; Apoptosis ; FoxO3a
• 刊名：Cellular and Molecular Neurobiology
• 出版年：2015
• 出版时间：May 2015
• 年：2015
• 卷：35
• 期：4
• 页码：513-522
• 全文大小：1,721 KB
• 参考文献：1. Akhter, R, Sanphui, P, Biswas, SC (2014) The essential role of p53-up-regulated modulator of apoptosis (Puma) and its regulation by FoxO3a transcription factor in beta-amyloid-induced neuron death. J Biol Chem 289: pp. 10812-10822 CrossRef
  2. Albani, D, Polito, L, Signorini, A, Forloni, G (2010) Neuroprotective properties of resveratrol in different neurodegenerative disorders. BioFactors 36: pp. 370-376 CrossRef
  3. Arab, L, Sadeghi, R, Walker, DG, Lue, LF, Sabbagh, MN (2011) Consequences of aberrant insulin regulation in the brain: can treating diabetes be effective for Alzheimer鈥檚 disease. Curr Neuropharmacol 9: pp. 693-705 CrossRef
  4. Bournival, J, Quessy, P, Martinoli, MG (2009) Protective effects of resveratrol and quercetin against MPP+-induced oxidative stress act by modulating markers of apoptotic death in dopaminergic neurons. Cell Mol Neurobiol 29: pp. 1169-1180 CrossRef
  5. Bournival, J, Francoeur, MA, Renaud, J, Martinoli, MG (2012) Quercetin and sesamin protect neuronal PC12 cells from high-glucose-induced oxidation, nitrosative stress, and apoptosis. Rejuvenation Res 15: pp. 322-333 CrossRef
  6. Cao, M, Jiang, J, Du, Y, Yan, P (2012) Mitochondria-targeted antioxidant attenuates high glucose-induced P38 MAPK pathway activation in human neuroblastoma cells. Mol Med Rep 5: pp. 929-934
  7. Cui, H, Kong, Y, Zhang, H (2012) Oxidative stress, mitochondrial dysfunction, and aging. J Signal Transduct 2012: pp. 646354 CrossRef
  8. Monte, SM, Tong, M (2014) Brain metabolic dysfunction at the core of Alzheimer鈥檚 disease. Biochem Pharmacol 88: pp. 548-559 CrossRef
  9. Foti Cuzzola, V, Ciurleo, R, Giacoppo, S, Marino, S, Bramanti, P (2011) Role of resveratrol and its analogues in the treatment of neurodegenerative diseases: focus on recent discoveries. CNS Neurol Disord: Drug Targets 10: pp. 849-862 CrossRef
  10. Hoeijmakers, JG, Faber, CG, Merkies, IS, Waxman, SG (2014) Channelopathies, painful neuropathy, and diabetes: which way does the causal arrow point?. Trends Mol Med 20: pp. 544-550 CrossRef
  11. Hsieh, HL, Yang, CM (2013) Role of redox signaling in neuroinflammation and neurodegenerative diseases. Biomed Res Int 2013: pp. 484613
  12. Jia, Y, Mo, SJ, Feng, QQ, Zhan, ML, Ouyang, LS, Chen, JC, Ma, YX, Wu, JJ, Lei, WL (2014) EPO-dependent activation of PI3K/Akt/FoxO3a signalling mediates neuroprotection in in vitro and in vivo models of Parkinson鈥檚 disease. J Mol Neurosci 53: pp. 117-124 CrossRef
  13. Kamal, MA, Priyamvada, S, Anbazhagan, AN, Jabir, NR, Tabrez, S, Greig, NH (2014) Linking Alzheimer鈥檚 disease and type 2 diabetes mellitus via aberrant insulin signaling and inflammation. CNS Neurol Disord: Drug Targets 13: pp. 338-346 CrossRef
  14. Li, D, Qu, Y, Mao, M, Zhang, X, Li, J, Ferriero, D, Mu, D (2009) Involvement of the PTEN-AKT-FOXO3a pathway in neuronal apoptosis in developing rat brain after hypoxia-ischemia. J Cereb Blood Flow Metab 29: pp. 1903-1913 CrossRef
  15. Liu, X, Xiao, Q, Zhao, K, Gao, Y (2013) Ghrelin inhibits high glucose-induced PC12 cell apoptosis by regulating TLR4/NF-kappaB pathway. Inflammation 36: pp. 1286-1294 CrossRef
  16. Luque-Contreras, D, Carvajal, K, Toral-Rios, D, Franco-Bocanegra, D, Campos-Pena, V (2014) Oxidative stress and metabolic syndrome: cause or consequence of Alzheimer鈥檚 disease?. Oxid Med Cell Longev 2014: pp. 497802 CrossRef
  17. Martin, TF, Grishanin, RN (2003) PC12 cells as a model for studies of regulated secretion in neuronal and endocrine cells. Methods Cell Biol 71: pp. 267-286 CrossRef
  18. Monsalve, M, Olmos, Y (2011) The complex biology of FOXO. Curr Drug Targets 12: pp. 1322-1350 CrossRef
  19. Nakamura, T, Sakamoto, K (2008) Forkhead transcription factor FOXO subfamily is essential for reactive oxygen species-induced apoptosis. Mol Cell Endocrinol 281: pp. 47-55 CrossRef
  20. Peng, C, Ma, J, Gao, X, Tian, P, Li, W, Zhang, L (2013) High glucose induced oxidative stress and apoptosis in cardiac microvascular endothelial cells are regulated by FoxO3a. PLoS ONE 8: pp. e79739 CrossRef
  21. Radi, E, Formichi, P, Battisti, C, Federico, A (2014) Apoptosis and oxidative stress in neurodegenerative diseases. J Alzheimers Dis 42: pp. S125-S152
  22. Renaud, J, Bournival, J, Zottig, X, Martinoli, MG (2014) Resveratrol protects DAergic PC12 cells from high glucose-induced oxidative stress and apoptosis: effect on p53 and GRP75 localization. Neurotox Res 25: pp. 110-123 CrossRef
  23. Sanphui, P, Biswas, SC (2013) FoxO3a is activated and executes neuron death via Bim in response to beta-amyloid. Cell Death Dis 4: pp. e625 CrossRef
  24. Simao, F, Matte, A, Pagnussat, AS, Netto, CA, Salbego, CG (2012) Resveratrol prevents CA1 neurons against ischemic injury by parallel modulation of both GSK-3beta and CREB through PI3-K/Akt pathways. Eur J Neurosci 36: pp. 2899-2905 CrossRef
  25. Styskal, J, Remmen, H, Richardson, A, Salmon, AB (2012) Oxidative stress and diabetes: what can we learn about insulin resistance from antioxidant mutant mouse models?. Free Radic Biol Med 52: pp. 46-58 CrossRef
  26. Tomlinson, DR, Gardiner, NJ (2008) Glucose neurotoxicity. Nat Rev Neurosci 9: pp. 36-45 CrossRef
  27. Uranga, RM, Katz, S, Salvador, GA (2013) Enhanced phosphatidylinositol 3-kinase (PI3K)/Akt signaling has pleiotropic targets in hippocampal neurons exposed to iron-induced oxidative stress. J Biol Chem 288: pp. 19773-19784 CrossRef
  28. Wang, H, Zhou, X, Huang, J, Mu, N, Guo, Z, Wen, Q, Wang, R, Chen, S, Feng, ZP, Zheng, W (2013) The role of Akt/FoxO3a in the protective effect of venlafaxine against corticosterone-induced cell death in PC12 cells. Psychopharmacology 228: pp. 129-141 CrossRef
  29. Wilk, A, Urbanska, K, Yang, S, Wang, JY, Amini, S, Valle, L, Peruzzi, F, Meggs, L, Reiss, K (2011) Insulin-like growth factor-I-forkhead box O transcription factor 3a counteracts high glucose/tumor necrosis factor-alpha-mediated neuronal damage: implications for human immunodeficiency virus encephalitis. J Neurosci Res 89: pp. 183-198 CrossRef
  30. Wu, PF, Xie, N, Zhang, JJ, Guan, XL, Zhou, J, Long, LH, Li, YL, Xiong, QJ, Zeng, JH, Wang, F, Chen, JG (2013) Resveratrol preconditioning increases methionine sulfoxide reductases A expression and enhances resistance of human neuroblastoma cells to neurotoxins. J Nutr Biochem 24: pp. 1070-1077 CrossRef
  31. Yan, LJ (2014) Pathogenesis of chronic hyperglycemia: from reductive stress to oxidative stress. J Diabetes Res 2014: pp. 137919
  32. Zhang, S, Zhao, Y, Xu, M, Yu, L, Chen, J, Yuan, Y, Zheng, Q, Niu, X (2013) FoxO3a modulates hypoxia stress induced oxidative stress and apoptosis in cardiac microvascular endothelial cells. PLoS ONE 8: pp. e80342 CrossRef
  33. Zheng, WH, Kar, S, Quirion, R (2000) Insulin-like growth factor-1-induced phosphorylation of the forkhead family transcription factor FKHRL1 is mediated by Akt kinase in PC12 cells. J Biol Chem 275: pp. 39152-39158 CrossRef
  34. Zhou, XM, Zhou, ML, Zhang, XS, Zhuang, Z, Li, T, Shi, JX, Zhang, X (2014) Resveratrol prevents neuronal apoptosis in an early brain injury model. J Surg Res 189: pp. 159-165 CrossRef
  
• 刊物类别：Biomedical and Life Sciences
• 刊物主题：Biomedicine
  Neurosciences
  Animal Anatomy, Morphology and Histology
  
• 出版者：Springer Netherlands
• ISSN：1573-6830

文摘

Diabetes is known to be associated with neurodegenerative diseases. Resveratrol, a plant-derived polyphenolic compound found in red wine, possesses antioxidant properties. In this study, we aimed to investigate the effects of resveratrol on the phosphatidylinositol-3-kinase/protein kinase B (PI3K/Akt)/FoxO3a pathway in mediating high glucose (HG)-induced injuries in neuronal PC12 cells. PC12 cells were exposed to HG to establish a model of HG neurotoxicity. Results showed that pre-treating PC12 cells with resveratrol before exposure to HG led to increased cell viability, decreased apoptotic cells, and reactive oxygen species generation. Western blot analysis showed that HG decreased the phosphorylation of Akt and FoxO3a and led to the nuclear localization of FoxO3a. These effects were significantly alleviated by resveratrol co-treatment. Furthermore, the protective effects of resveratrol were abolished by PI3K/Akt inhibitor LY294002. All these results demonstrate that resveratrol protected the PC12 cells from HG-induced oxidative stress and apoptosis via the activation of PI3K/Akt/FoxO3a signaling pathway.