NHC-initiated cascade, metal-free synthesis of quinoxaline derivatives under solvent-free conditions

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• 作者：Lijiu Gao (1)
  Rui Liu (1)
  Chenxia Yu (1)
  Changsheng Yao (2)
  Tuanjie Li (1)
  Zhaoxin Xiao (2)
  
• 关键词：Cascade reaction ; Quinoxalines ; N ; Heterocyclic carbene (NHC) ; Solvent ; free synthesis
• 刊名：Research on Chemical Intermediates
• 出版年：2014
• 出版时间：May 2014
• 年：2014
• 卷：40
• 期：5
• 页码：2131-2138
• 全文大小：248 KB
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• 作者单位：Lijiu Gao (1)
  Rui Liu (1)
  Chenxia Yu (1)
  Changsheng Yao (2)
  Tuanjie Li (1)
  Zhaoxin Xiao (2)
  
  1. School of Chemistry and Engineering, Jiangsu Key Laboratory of Green Synthetic Chemistry for Functional Materials, Jiangsu Normal University, Xuzhou, Jiangsu, 221116, People鈥檚 Republic of China
  2. School of Chemistry and Chemical Engineering, Key Laboratory of Biotechnology on Medical Plant, Jiangsu Normal University, Xuzhou, Jiangsu, 221116, People鈥檚 Republic of China
  
• ISSN：1568-5675

文摘

2,3-Diaryl quinoxaline derivatives have been efficiently synthesized by cascade, metal-free, and solvent-free reaction of aryl aldehydes with aryl 1,2-diamines initiated by N-heterocyclic carbene. Compared with reported methods, this procedure has the advantages of easy work-up, reduced energy consumption, and elimination of solvent waste, hazards, and toxicity. A group of potentially bioactive compounds has been prepared for biomedical screening.