Genome-wide comparison of ferritin family from Archaea, Bacteria, Eukarya, and Viruses: its distribution, characteristic motif, and phylogenetic relationship

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• 作者：Lina Bai ; Ting Xie ; Qingqing Hu ; Changyan Deng ; Rong Zheng…
• 关键词：Ferritin ; Bacterioferritin ; Phytoferritin ; Characteristic motif ; Evolution
• 刊名：Naturwissenschaften
• 出版年：2015
• 出版时间：October 2015
• 年：2015
• 卷：102
• 期：9-10
• 全文大小：15,361 KB
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• 作者单位：Lina Bai (1)
  Ting Xie (2)
  Qingqing Hu (1)
  Changyan Deng (1)
  Rong Zheng (1)
  Wanping Chen (3)
  
  1. Key Laboratory of Pig Genetics and Breeding of Ministry of Agriculture and Key Laboratory of Agricultural Animal Genetics, Breeding and Reproduction of Ministry of Education, Huazhong Agricultural University, Wuhan, Hubei Province, China
  2. College of Informatics, Huazhong Agricultural University, Wuhan, Hubei Province, China
  3. College of Food Science and Technology, Huazhong Agricultural University, Wuhan, Hubei Province, China
  
• 刊物类别：Biomedical and Life Sciences
• 刊物主题：Life Sciences
  Life Sciences
  Environment
  
• 出版者：Springer Berlin / Heidelberg
• ISSN：1432-1904

文摘

Ferritins are highly conserved proteins that are widely distributed in various species from archaea to humans. The ubiquitous characteristic of these proteins reflects the pivotal contribution of ferritins to the safe storage and timely delivery of iron to achieve iron homeostasis. This study investigated the ferritin genes in 248 genomes from various species, including viruses, archaea, bacteria, and eukarya. The distribution comparison suggests that mammals and eudicots possess abundant ferritin genes, whereas fungi contain very few ferritin genes. Archaea and bacteria show considerable numbers of ferritin genes. Generally, prokaryotes possess three types of ferritin (the typical ferritin, bacterioferritin, and DNA-binding protein from starved cell), whereas eukaryotes have various subunit types of ferritin, thereby indicating the individuation of the ferritin family during evolution. The characteristic motif analysis of ferritins suggested that all key residues specifying the unique structural motifs of ferritin are highly conserved across three domains of life. Meanwhile, the characteristic motifs were also distinguishable between ferritin groups, especially phytoferritins, which show a plant-specific motif. The phylogenetic analyses show that ferritins within the same subfamily or subunits are generally clustered together. The phylogenetic relationships among ferritin members suggest that both gene duplication and horizontal transfer contribute to the wide variety of ferritins, and their possible evolutionary scenario was also proposed. The results contribute to a better understanding of the distribution, characteristic motif, and evolutionary relationship of the ferritin family.