PKD2L1/PKD1L3 channel complex with an alkali-activated mechanism and calcium-dependent inactivation

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• 作者：Peihua Chen ; Jin-zhi Wu ; Jie Zhao ; Ping Wang ; Jianhong Luo…
• 关键词：PKD2L1/PKD1L3 channel ; Off ; response (I off) ; Calcium ; Alkali ; activated ; TRPP3
• 刊名：European Biophysics Journal
• 出版年：2015
• 出版时间：September 2015
• 年：2015
• 卷：44
• 期：6
• 页码：483-492
• 全文大小：2,378 KB
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• 作者单位：Peihua Chen (1) (2)
  Jin-zhi Wu (3)
  Jie Zhao (1) (2)
  Ping Wang (1) (2)
  Jianhong Luo (1) (2)
  Wei Yang (1) (2)
  Xiao-dong Liu (3)
  
  1. Key Laboratory for Biomedical Engineering of Ministry of Education of China, Department of Biomedical Engineering, School of Biomedical Engineering and Instrument Science, Zhejiang University, Hangzhou, China
  2. Key Laboratory of Medical Neurobiology of Ministry of Health of China, Zhejiang Province Key Laboratory of Neurobiology, Department of Neurobiology, School of Medicine, Zhejiang University, Hangzhou, 310058, China
  3. X-Laboratory, Department of Biomedical Engineering, School of Medicine, School of Life Sciences, Tsinghua University, Beijing, China
  
• 刊物类别：Physics and Astronomy
• 刊物主题：Physics
  Biophysics and Biomedical Physics
  Cell Biology
  Biochemistry
  Plant Physiology
  Animal Physiology
  Neurobiology
  
• 出版者：Springer Berlin / Heidelberg
• ISSN：1432-1017

文摘

Polycystic kidney disease-like (PKDL) genes that are expressed in sour taste cells have been proposed to be involved in the transduction of sourness by producing off-responses, which shows a large inward current after withdrawing the acid stimuli. However, the underlying mechanisms of off-responses are still unclear. Here, we demonstrate that an alkali–activated mechanism is responsible for eliciting off-responses, as evidenced by both experimental and theoretical analyses. In addition, we showed that the decaying phase of offset responses in PKD2L1/PKD1L3 channels was substantially accelerated by extracellular Ca2+.